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Graphene sensor platform for COVID 19 detection in checkpoints

Graphene sensor platform for COVID 19 detection in checkpoints
Project details How to apply 

In order to mitigate the spread of the current global COVID-19 pandemic, fast, accurate, sensitive and easy-to-use methods for testing large number of individuals are paramount. The experimental work for this PhD project will be performed as member of an interdisciplinary research team within Imperial’s Department of Materials  https://www.imperial.ac.uk/people/n.klein/research.html , whose current research activities are concentrated on chip-based biosensors, which potentially can be fabricated in large quantities by wafer-scaled transfer of CVD-graphene on silicon wafers and wafer-scaled device fabrication by standard photolithography processes. Direct sensing of virus particles is realized through nanoparticle-enhanced graphene surfaces functionalized with specific SARS-CoV-2 antibodies and quantitative electrical detection based on the electric field effect in graphene. Our approach, which has been originally developed for the detection of exosomes [1], has already been successfully tested for the detection of COVID-19 spike proteins. It is expected that this technology will outperform standard PCR methods for COVID-19 detection [2].

The student will received extensive training in device microfabrication techniques including photolithography and thin film deposition, but also techniques for biofunctionalization, advanced electrical characterization, atomic force microscopy, Raman spectroscopy and fluorescence microscopy. A good understanding of materials-related topics in Physics and Chemistry is important, but we also accept applicants with Electrical or Chemical/Bioengineering background. The project is aiming to bring this technology forward to real world applications, which may include pilot studies in medical points-of-care or airport passenger checkpoints.

The project is fully funded, but based on the nature of funding restricted to home student applicants. Due to exceptional circumstances we accept any starting date from now to January 2021. For further information you may contact the supervisor Prof Norbert Klein n.klein@imperial.ac.uk.

[1]  Kwong Hong Tsang, D et al., Scientific Reports 2019, 9, (1), 13946

[2] see our recent review article in “Biosensors and Bioelectronics”  https://www.sciencedirect.com/science/article/pii/S095656632030662X


Supervisor: Prof Norbert Klein and Prof Deeph S Chana

 

Start date: January 2021
Duration:
36 months 
Position available: 
1

Funding: 
A 3 year fully funded PhD studentship in the Department of Materials at Imperial College London is open to UK students.


Deadline:
15th of December 2020

>> To apply, please, send your CV, transcripts and research proposal to Prof Norbert Klein, together with two references, before the deadline
PhD Project