Features

The Globe_Toolbox offers a graphical user interface for fitting of time- resolved data via global analysis. Extensive control over fitting parameters and dataset preprocessing is supplied. A global analysis requires a model (a number of which is supplied). Any model can also be constructed with the help of the Simbiology Toolbox. This model is consequently fitted to the data by numerically solving the differentical equations describing that model. In addition, it is possible to explore the parameter space with a Direct Search method (by using patternsearch, which is part of the Genetic Algorithm and Direct Search Toolbox).

Program capabilities:

Sequential and parallel models are built-in up to 6 components by using supplied '.xml' files. Any combination of those two is possible by creating user-defined 'Target' models. Parameters can be fixed. Error estimation in fitted decay times and time/OD-offset. Models are formed by importing files in SBML format. Data can be analysed in different ways: Fully, or any (continuous) part of the provided data. Alternatively, the left singular vectors obtained from singular value decomposition (SVD) can be fitted.

See Also

- Limitations