Current Research Topics
We research the epidemiology of infectious diseases and vaccines, with expertise in math modelling, statistics, clinical trial design and genomics. We are interested in how vaccine efficacy and effectiveness is measured, the impact of vaccination on disease dynamics and optimal vaccination strategies. We have over 15 years’ experience working on the epidemiology of vaccines, including those against polio, typhoid, rotavirus diarrhoea, and most recently COVID-19.
Williams LR, Ferguson NM, Donnelly CA, Grassly NC. 2021. Measuring vaccine efficacy against infection and disease in clinical trials: sources and magnitude of bias in COVID-19 vaccine efficacy estimates. medRxiv doi:10.1101/2021.07.30.21260912:2021.07.30.21260912.
Cooper LV, Bandyopadhyay A, Gumede N, Mach O, Mkanda P, Ndoutabe M, Okiror S, Ramirez-Gonzalez A, Touray K, Wanyoike S, Grassly NC, Blake IM. 2021. Risk factors for spread of vaccine-derived type 2 polioviruses in Africa following global withdrawal of trivalent oral poliovirus vaccine and impact of outbreak response with monovalent vaccine: a retrospective analysis of surveillance data. Lancet Infectious Diseases. In press.
Grassly NC, Pons-Salort M, Parker EPK, White PJ, Ferguson NM, Ainslie K, Baguelin M, Bhatt S, Boonyasiri A, Brazeau N, Cattarino L, Coupland H, Cucunuba Z, Cuomo-Dannenburg G, Dighe A, Donnelly C, van Elsland SL, FitzJohn R, Flaxman S, Fraser K, Gaythorpe K, Green W, Hamlet A, Hinsley W, Imai N, Knock E, Laydon D, Mellan T, Mishra S, Nedjati-Gilani G, Nouvellet P, Okell L, Ragonnet-Cronin M, Thompson HA, Unwin HJT, Vollmer M, Volz E, Walters C, Wang Y, Watson OJ, Whittaker C, Whittles L, Xi X. 2020. Comparison of molecular testing strategies for COVID-19 control: a mathematical modelling study. The Lancet Infectious Diseases 20:1381-1389.
Disease surveillance and genomics
We research novel approaches to infectious disease surveillance, including the use of serological surveys, environmental (sewage) surveillance and next-generation (nanopore) sequencing. We have developed a novel method for poliovirus detection and sequencing, which is being investigated for its potential to accelerate poliovirus detection and outbreak response. We are also investigating environmental surveillance for typhoid and other enteric pathogens, with research partners around the world including India, Malawi, Ghana and Fiji.
Shaw A, Cooper L, Gumede N, Bandyopadhyay AS, Grassly NC, Blake IM. 2021. Time taken to detect and respond to polio outbreaks in Africa and the potential impact of direct molecular detection and nanopore sequencing, Journal of Infectious Diseases, ISSN:0022-1899 in press
Shaw AG, Troman C, Grassly N. 2020. Rapid and sensitive direct detection and identification of poliovirus from stool and environmental surveillance samples using nanopore sequencing, Journal of Clinical Microbiology, Vol: 58, Pages: 1-13, ISSN: 0095-1137
Uzzell CB, Troman CM, Rigby J, Mohan VR, John J, Abraham D, Srinivasan R, Nair S, Meschke JS, Elviss N, Kang G, Feasey N, Grassly NC. 2021. Environmental surveillance for Salmonella Typhi as a tool to estimate the incidence of typhoid fever in low-income populations. medRxiv doi:10.1101/2021.05.21.21257547:2021.05.21.21257547.
Immune correlates of protection by vaccination
We investigate factors affecting the immune response to vaccination and immune correlates of protection (CoP) following vaccination. This work is focused particularly on the mucosal immune response to rotavirus and poliovirus vaccines and protection against challenge with live-attenuated vaccine virus.
Chilengi R, Simuyandi M, Chibuye M, Chirwa M, Sukwa N, Laban N, Chisenga C, Silwamba S, Grassly N, Bosomprah Set al., 2020, A pilot study on use of live attenuated rotavirus vaccine (Rotarix (TM)) as an infection challenge model, VACCINE, Vol: 38, Pages: 7357-7362, ISSN: 0264-410X
Babji S, Manickavasagam P, Chen Y-H, Jeyavelu N, Jose NV, Praharaj I, Syed C, Kaliappan SP, John J, Giri S, Venugopal S, Kampmann B, Parker EPK, Iturriza-Gómara M, Kang G, Grassly NC, Uhlig HH, 2020, Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India., NPJ Vaccines, Vol: 5
Praharaj I, Parker EPK, Giri S, Allen D, Silas S, Revathi R, Kalliappan S, John J, Prasad J, Kampmann B, Iturriza-Gómara M, Grassly N, Kang Get al., 2019, Influence of nonpolio enteroviruses and the bacterial gut microbiota on oral poliovirus vaccine response: A study from south India, Journal of Infectious Diseases, Vol: 219, Pages: 1178-1186, ISSN: 0022-1899