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• Journal article
  Freeman EE, Orroth KK, White RG, Glynn JR, Bakker R, Boily M-C, Habbema D, Buve A, Hayes RJet al., 2007,

  Proportion of new HIV infections attributable to herpes simplex 2 increases over time:: simulations of the changing role of sexually transmitted infections in sub-Saharan African HIV epidemics

  , SEXUALLY TRANSMITTED INFECTIONS, Vol: 83, Pages: I17-I24, ISSN: 1368-4973
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  • Citations: 82
• Journal article
  Abu-Raddad LJ, Boily M-C, Self S, Longini IMet al., 2007,

  Analytic insights into the population level impact of imperfect prophylactic HIV vaccines

  , JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 45, Pages: 454-467, ISSN: 1525-4135
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  • Citations: 18
• Journal article
  Hallett TB, White PJ, Garnett GP, 2007,

  Appropriate evaluation of HIV prevention interventions: from experiment to full-scale implementation

  , SEXUALLY TRANSMITTED INFECTIONS, Vol: 83, Pages: I55-I60, ISSN: 1368-4973
  • Author Web Link
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  • Citations: 39
• Journal article
  Orroth KK, Freeman EE, Bakker R, Buve A, Glynn JR, Boily M-C, White RG, Habbema JDF, Hayes RJet al., 2007,

  Understanding the differences between contrasting HIV epidemics in east and west Africa:: results from a simulation model of the Four Cities Study

  , SEXUALLY TRANSMITTED INFECTIONS, Vol: 83, Pages: I5-I16, ISSN: 1368-4973
  • Author Web Link
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  • Citations: 59
• Journal article
  Hallett TB, Gregson S, Lewis JJC, Lopman BA, Garnett GPet al., 2007,

  Behaviour change in generalised HIV epidemics: impact of reducing cross-generational sex and delaying age at sexual debut

  , SEXUALLY TRANSMITTED INFECTIONS, Vol: 83, Pages: I50-I54, ISSN: 1368-4973
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  • Citations: 85
• Journal article
  Wong SY, Haack H, Kissil JL, Barry M, Bronson RT, Shen SS, Whittaker CA, Crowley D, Hynes ROet al., 2007,

  Protein 4.1B suppresses prostate cancer progression and metastasis.

  , Proc Natl Acad Sci U S A, Vol: 104, Pages: 12784-12789, ISSN: 0027-8424

  Protein 4.1B is a 4.1/ezrin/radixin/moesin domain-containing protein whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers, and breast carcinomas. However, its potential tumor-suppressive function under in vivo conditions remains to be validated. In a screen for genes involved with prostate cancer metastasis, we found that 4.1B expression is reduced in highly metastatic tumors. Down-regulation of 4.1B increased the metastatic propensity of poorly metastatic cells in an orthotopic model of prostate cancer. Furthermore, 4.1B-deficient mice displayed increased susceptibility for developing aggressive, spontaneous prostate carcinomas. In both cases, enhanced tumor malignancy was associated with reduced apoptosis. Because expression of Protein 4.1B is frequently down-regulated in human clinical prostate cancer, as well as in a spectrum of other tumor types, these results suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease.

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• Journal article
  Hancock PA, Godfray HCJ, 2007,

  Application of the lumped age-class technique to studying the dynamics of malaria-mosquito-human interactions

  , MALARIA JOURNAL, Vol: 6
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  • Citations: 33
• Journal article
  van Boven M, Koopmans M, van Beest Holle MDR, Meijer A, Klinkenberg D, Donnelly CA, Heesterbeek HJAPet al., 2007,

  Detecting emerging transmissibility of avian influenza virus in human households

  , PLOS Computational Biology, Vol: 3, Pages: 1394-1402, ISSN: 1553-734X

  Accumulating infections of highly pathogenic H5N1 avian influenza in humans underlines the need to track the ability of these viruses to spread among humans. A human-transmissible avian influenza virus is expected to cause clusters of infections in humans living in close contact. Therefore, epidemiological analysis of infection clusters in human households is of key importance. Infection clusters may arise from transmission events from (i) the animal reservoir, (ii) humans who were infected by animals (primary human-to-human transmission), or (iii) humans who were infected by humans (secondary human-to-human transmission). Here we propose a method of analysing household infection data to detect changes in the transmissibility of avian influenza viruses in humans at an early stage. The method is applied to an outbreak of H7N7 avian influenza virus in The Netherlands that was the cause of more than 30 human-to-human transmission events. The analyses indicate that secondary human-to-human transmission is plausible for the Dutch household infection data. Based on the estimates of the within-household transmission parameters, we evaluate the effectiveness of antiviral prophylaxis, and conclude that it is unlikely that all household infections can be prevented with current antiviral drugs. We discuss the applicability of our method for the detection of emerging human-to-human transmission of avian influenza viruses in particular, and for the analysis of within-household infection data in general.

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• Journal article
  Chindelevitch L, Nicholls DP, Nigam N, 2007,

  Error analysis and preconditioning for an enhanced DtN-FE algorithm for exterior scattering problems

  , JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS, Vol: 204, Pages: 493-504, ISSN: 0377-0427
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  • Citations: 5
• Journal article
  Grassly NC, Wenger J, Bahl S, Sutter RW, Aylward RBet al., 2007,

  Protective efficacy of a monovalent oral type 1 poliovirus vaccine - Reply

  , LANCET, Vol: 370, Pages: 129-130, ISSN: 0140-6736
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  • Citations: 1

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