BibTex format
@article{Nusbaum:2006:10.1038/nature04406,
author = {Nusbaum, C and Mikkelsen, TS and Zody, MC and Asakawa, S and Taudien, S and Garber, M and Kodira, CD and Schueler, MG and Shimizu, A and Whittaker, CA and Chang, JL and Cuomo, CA and Dewar, K and FitzGerald, MG and Yang, X and Allen, NR and Anderson, S and Asakawa, T and Blechschmidt, K and Bloom, T and Borowsky, ML and Butler, J and Cook, A and Corum, B and DeArellano, K and DeCaprio, D and Dooley, KT and Dorris, L and Engels, R and Glöckner, G and Hafez, N and Hagopian, DS and Hall, JL and Ishikawa, SK and Jaffe, DB and Kamat, A and Kudoh, J and Lehmann, R and Lokitsang, T and Macdonald, P and Major, JE and Matthews, CD and Mauceli, E and Menzel, U and Mihalev, AH and Minoshima, S and Murayama, Y and Naylor, JW and Nicol, R and Nguyen, C and O'Leary, SB and O'Neill, K and Parker, SCJ and Polley, A and Raymond, CK and Reichwald, K and Rodriguez, J and Sasaki, T and Schilhabel, M and Siddiqui, R and Smith, CL and Sneddon, TP and Talamas, JA and Tenzin, P and Topham, K and Venkataraman,},
doi = {10.1038/nature04406},
journal = {Nature},
pages = {331--335},
title = {DNA sequence and analysis of human chromosome 8.},
url = {http://dx.doi.org/10.1038/nature04406},
volume = {439},
year = {2006}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - The International Human Genome Sequencing Consortium (IHGSC) recently completed a sequence of the human genome. As part of this project, we have focused on chromosome 8. Although some chromosomes exhibit extreme characteristics in terms of length, gene content, repeat content and fraction segmentally duplicated, chromosome 8 is distinctly typical in character, being very close to the genome median in each of these aspects. This work describes a finished sequence and gene catalogue for the chromosome, which represents just over 5% of the euchromatic human genome. A unique feature of the chromosome is a vast region of approximately 15 megabases on distal 8p that appears to have a strikingly high mutation rate, which has accelerated in the hominids relative to other sequenced mammals. This fast-evolving region contains a number of genes related to innate immunity and the nervous system, including loci that appear to be under positive selection--these include the major defensin (DEF) gene cluster and MCPH1, a gene that may have contributed to the evolution of expanded brain size in the great apes. The data from chromosome 8 should allow a better understanding of both normal and disease biology and genome evolution.
AU - Nusbaum,C
AU - Mikkelsen,TS
AU - Zody,MC
AU - Asakawa,S
AU - Taudien,S
AU - Garber,M
AU - Kodira,CD
AU - Schueler,MG
AU - Shimizu,A
AU - Whittaker,CA
AU - Chang,JL
AU - Cuomo,CA
AU - Dewar,K
AU - FitzGerald,MG
AU - Yang,X
AU - Allen,NR
AU - Anderson,S
AU - Asakawa,T
AU - Blechschmidt,K
AU - Bloom,T
AU - Borowsky,ML
AU - Butler,J
AU - Cook,A
AU - Corum,B
AU - DeArellano,K
AU - DeCaprio,D
AU - Dooley,KT
AU - Dorris,L
AU - Engels,R
AU - Glöckner,G
AU - Hafez,N
AU - Hagopian,DS
AU - Hall,JL
AU - Ishikawa,SK
AU - Jaffe,DB
AU - Kamat,A
AU - Kudoh,J
AU - Lehmann,R
AU - Lokitsang,T
AU - Macdonald,P
AU - Major,JE
AU - Matthews,CD
AU - Mauceli,E
AU - Menzel,U
AU - Mihalev,AH
AU - Minoshima,S
AU - Murayama,Y
AU - Naylor,JW
AU - Nicol,R
AU - Nguyen,C
AU - O'Leary,SB
AU - O'Neill,K
AU - Parker,SCJ
AU - Polley,A
AU - Raymond,CK
AU - Reichwald,K
AU - Rodriguez,J
AU - Sasaki,T
AU - Schilhabel,M
AU - Siddiqui,R
AU - Smith,CL
AU - Sneddon,TP
AU - Talamas,JA
AU - Tenzin,P
AU - Topham,K
AU - Venkataraman,V
AU - Wen,G
AU - Yamazaki,S
AU - Young,SK
AU - Zeng,Q
AU - Zimmer,AR
AU - Rosenthal,A
AU - Birren,BW
AU - Platzer,M
AU - Shimizu,N
AU - Lander,ES
DO - 10.1038/nature04406
EP - 335
PY - 2006///
SP - 331
TI - DNA sequence and analysis of human chromosome 8.
T2 - Nature
UR - http://dx.doi.org/10.1038/nature04406
UR - https://www.ncbi.nlm.nih.gov/pubmed/16421571
VL - 439
ER -