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Journal articleRudge JW, Carabin H, Balolong E, et al., 2008,
Population Genetics of <i>Schistosoma japonicum</i> within the Philippines Suggest High Levels of Transmission between Humans and Dogs
, PLOS NEGLECTED TROPICAL DISEASES, Vol: 2, ISSN: 1935-2735- Cite
- Citations: 61
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Journal articleBasanez M-G, 2008,
Mathematical modelling of parasitic infections: from data and parameter estimation to evolutionary implications
, PARASITOLOGY, Vol: 135, Pages: 1487-1488, ISSN: 0031-1820- Author Web Link
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- Citations: 1
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Journal articleWilliams BR, Prabhu VR, Hunter KE, et al., 2008,
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.
, Science, Vol: 322, Pages: 703-709Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes. In all four trisomic lines, proliferation was impaired and metabolic properties were altered. Immortalization, the acquisition of the ability to proliferate indefinitely, was also affected by the presence of an additional copy of certain chromosomes. Our data indicate that aneuploidy decreases not only organismal but also cellular fitness and elicits traits that are shared between different aneuploid cells.
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Journal articleJenkins HE, Aylward RB, Gasasira A, et al., 2008,
Effectiveness of immunization against paralytic poliomyelitis in Nigeria
, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 359, Pages: 1666-U111, ISSN: 0028-4793- Author Web Link
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- Citations: 50
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Journal articleFry RC, Svensson JP, Valiathan C, et al., 2008,
Genomic predictors of interindividual differences in response to DNA damaging agents.
, Genes Dev, Vol: 22, Pages: 2621-2626, ISSN: 0890-9369Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such variation in gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences in sensitivity across a diverse cell line panel exposed to an alkylating agent. Computational models identified 48 genes with basal expression that predicts susceptibility with 94% accuracy. Modulating transcript levels for two member genes, MYH and C21ORF56, confirmed that their expression does indeed influence alkylation sensitivity. Many proteins encoded by these genes are interconnected in cellular networks related to human cancer and tumorigenesis.
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Journal articlePaez A, Scott DM, Volz E, 2008,
Weight matrices for social influence analysis: An investigation of measurement errors and their effect on model identification and estimation quality
, SOCIAL NETWORKS, Vol: 30, Pages: 309-317, ISSN: 0378-8733- Cite
- Citations: 37
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Journal articleJenkins HE, Morrison WI, Cox DR, et al., 2008,
The prevalence, distribution and severity of detectable pathological lesions in badgers naturally infected with <i>Mycobacterium bovis</i>
, EPIDEMIOLOGY AND INFECTION, Vol: 136, Pages: 1350-1361, ISSN: 0950-2688- Author Web Link
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- Citations: 47
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Journal articleWalker PT, Hallett TB, White PJ, et al., 2008,
Interpreting declines in HIV prevalence: impact of spatial aggregation and migration on expected declines in prevalence
, SEXUALLY TRANSMITTED INFECTIONS, Vol: 84, Pages: II42-II48, ISSN: 1368-4973- Cite
- Citations: 19
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Journal articleBoily M-C, Desai K, Masse B, et al., 2008,
Incremental role of male circumcision on a generalised HIV epidemic through its protective effect against other sexually transmitted infections: from efficacy to effectiveness to population-level impact
, SEXUALLY TRANSMITTED INFECTIONS, Vol: 84, Pages: II28-II34, ISSN: 1368-4973- Author Web Link
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- Citations: 17
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Journal articleWilliams JR, Bórquez A, Basáñez MG, 2008,
Hispanic Latin America, Spain and the Spanish-speaking Caribbean: a rich source of reference material for public health, epidemiology and tropical medicine.
, Emerging Themes in Epidemiology, Vol: 5, ISSN: 1742-7622There is a multiplicity of journals originating in Spain and the Spanish-speaking countries of Latin America and the Caribbean (SSLAC) in the health sciences of relevance to the fields of epidemiology and public health. While the subject matter of epidemiology in Spain shares many features with its neighbours in Western Europe, many aspects of epidemiology in Latin America are particular to that region. There are also distinctive theoretical and philosophical approaches to the study of epidemiology and public health arising from traditions such as the Latin American social medicine movement, of which there may be limited awareness. A number of online bibliographic databases are available which focus primarily on health sciences literature arising in Spain and Latin America, the most prominent being Literatura Latinoamericana en Ciencias de la Salud (LILACS) and LATINDEX. Some such as LILACS also extensively index grey literature. As well as in Spanish, interfaces are provided in English and Portuguese. Abstracts of articles may also be provided in English with an increasing number of journals beginning to publish entire articles written in English. Free full text articles are becoming accessible, one of the most comprehensive sources being the Scientific Electronic Library Online (SciELO). There is thus an extensive range of literature originating in Spain and SSLAC freely identifiable and often accessible online, and with the potential to provide useful inputs to the study of epidemiology and public health provided that any reluctance to explore these resources can be overcome. In this article we provide an introduction to such resources.
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