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• Journal article
  Basanez M-G, 2008,

  Mathematical modelling of parasitic infections: from data and parameter estimation to evolutionary implications

  , PARASITOLOGY, Vol: 135, Pages: 1487-1488, ISSN: 0031-1820
  • Author Web Link
  • Cite
  • Citations: 1
• Journal article
  Rudge JW, Carabin H, Balolong E, Tallo V, Shrivastava J, Lu D-B, Basanez M-G, Olveda R, McGarvey ST, Webster JPet al., 2008,

  Population Genetics of <i>Schistosoma japonicum</i> within the Philippines Suggest High Levels of Transmission between Humans and Dogs

  , PLOS NEGLECTED TROPICAL DISEASES, Vol: 2, ISSN: 1935-2735
  • Cite
  • Citations: 61
• Journal article
  Bottomley C, Isham V, Collins RC, Basanez M-Get al., 2008,

  Rates of microfilarial production by <i>Onchocerca volvulus</i> are not cumulatively reduced by multiple ivermectin treatments

  , PARASITOLOGY, Vol: 135, Pages: 1571-1581, ISSN: 0031-1820
  • Author Web Link
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  • Citations: 25
• Journal article
  Riley S, 2008,

  A prospective study of spatial clusters gives valuable insights into dengue transmission.

  , PLoS Med, Vol: 5, Pages: e220-e220
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• Journal article
  Rhodes CJ, Anderson RM, 2008,

  Contact rate calculation for a basic epidemic model

  , MATHEMATICAL BIOSCIENCES, Vol: 216, Pages: 56-62, ISSN: 0025-5564
  • Cite
  • Citations: 27
• Journal article
  Trotter CL, Borrow R, Findlow J, Holland A, Frankland S, Andrews NJ, Miller Eet al., 2008,

  Seroprevalence of Antibodies against Serogroup C Meningococci in England in the Postvaccination Era

  , CLINICAL AND VACCINE IMMUNOLOGY, Vol: 15, Pages: 1694-1698, ISSN: 1556-6811
  • Cite
  • Citations: 57
• Journal article
  Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE, Amon Aet al., 2008,

  Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.

  , Science, Vol: 322, Pages: 703-709

  Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes. In all four trisomic lines, proliferation was impaired and metabolic properties were altered. Immortalization, the acquisition of the ability to proliferate indefinitely, was also affected by the presence of an additional copy of certain chromosomes. Our data indicate that aneuploidy decreases not only organismal but also cellular fitness and elicits traits that are shared between different aneuploid cells.

  • Abstract
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• Journal article
  Jenkins HE, Aylward RB, Gasasira A, Donnelly CA, Abanida EA, Koleosho-Adelekan T, Grassly NCet al., 2008,

  Effectiveness of immunization against paralytic poliomyelitis in Nigeria

  , NEW ENGLAND JOURNAL OF MEDICINE, Vol: 359, Pages: 1666-U111, ISSN: 0028-4793
  • Author Web Link
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  • Citations: 50
• Journal article
  Fry RC, Svensson JP, Valiathan C, Wang E, Hogan BJ, Bhattacharya S, Bugni JM, Whittaker CA, Samson LDet al., 2008,

  Genomic predictors of interindividual differences in response to DNA damaging agents.

  , Genes Dev, Vol: 22, Pages: 2621-2626, ISSN: 0890-9369

  Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such variation in gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences in sensitivity across a diverse cell line panel exposed to an alkylating agent. Computational models identified 48 genes with basal expression that predicts susceptibility with 94% accuracy. Modulating transcript levels for two member genes, MYH and C21ORF56, confirmed that their expression does indeed influence alkylation sensitivity. Many proteins encoded by these genes are interconnected in cellular networks related to human cancer and tumorigenesis.

  • Abstract
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• Journal article
  Jenkins HE, Morrison WI, Cox DR, Donnelly CA, Johnston WT, Bourne FJ, Clifton-Hadley RS, Gettinby G, McInerney JP, Watkins GH, Woodroffe Ret al., 2008,

  The prevalence, distribution and severity of detectable pathological lesions in badgers naturally infected with <i>Mycobacterium bovis</i>

  , EPIDEMIOLOGY AND INFECTION, Vol: 136, Pages: 1350-1361, ISSN: 0950-2688
  • Author Web Link
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  • Citations: 47

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