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• Journal article
  van Boven M, Koopmans M, van Beest Holle MDR, Meijer A, Klinkenberg D, Donnelly CA, Heesterbeek HJAPet al., 2007,

  Detecting emerging transmissibility of avian influenza virus in human households

  , PLOS Computational Biology, Vol: 3, Pages: 1394-1402, ISSN: 1553-734X

  Accumulating infections of highly pathogenic H5N1 avian influenza in humans underlines the need to track the ability of these viruses to spread among humans. A human-transmissible avian influenza virus is expected to cause clusters of infections in humans living in close contact. Therefore, epidemiological analysis of infection clusters in human households is of key importance. Infection clusters may arise from transmission events from (i) the animal reservoir, (ii) humans who were infected by animals (primary human-to-human transmission), or (iii) humans who were infected by humans (secondary human-to-human transmission). Here we propose a method of analysing household infection data to detect changes in the transmissibility of avian influenza viruses in humans at an early stage. The method is applied to an outbreak of H7N7 avian influenza virus in The Netherlands that was the cause of more than 30 human-to-human transmission events. The analyses indicate that secondary human-to-human transmission is plausible for the Dutch household infection data. Based on the estimates of the within-household transmission parameters, we evaluate the effectiveness of antiviral prophylaxis, and conclude that it is unlikely that all household infections can be prevented with current antiviral drugs. We discuss the applicability of our method for the detection of emerging human-to-human transmission of avian influenza viruses in particular, and for the analysis of within-household infection data in general.

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• Journal article
  Chindelevitch L, Nicholls DP, Nigam N, 2007,

  Error analysis and preconditioning for an enhanced DtN-FE algorithm for exterior scattering problems

  , JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS, Vol: 204, Pages: 493-504, ISSN: 0377-0427
  • Author Web Link
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  • Citations: 5
• Journal article
  Grassly NC, Wenger J, Bahl S, Sutter RW, Aylward RBet al., 2007,

  Protective efficacy of a monovalent oral type 1 poliovirus vaccine - Reply

  , LANCET, Vol: 370, Pages: 129-130, ISSN: 0140-6736
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  • Citations: 1
• Journal article
  Donnelly CA, Wei G, Johnston WT, Cox DR, Woodroffe R, Bourne FJ, Cheeseman CL, Clifton-Hadley RS, Gettinby G, Gilks P, Jenkins HE, Le Fevre AM, McInerney JP, Morrison WIet al., 2007,

  Impacts of widespread badger culling on cattle tuberculosis: concluding analyses from a large-scale field trial

  , INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol: 11, Pages: 300-308, ISSN: 1201-9712
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  • Citations: 99
• Journal article
  Wetten S, Collins RC, Vieira JC, Marshallb C, Shelley AJ, Basanez M-Get al., 2007,

  Vector competence for <i>Onchocerca volvulus</i> in the Simulium (<i>Notolepria</i>) <i>exiguum</i> complex:: Cytoforms or density-dependence?

  , ACTA TROPICA, Vol: 103, Pages: 58-68, ISSN: 0001-706X
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  • Citations: 8
• Journal article
  Schwab AE, Churcher TS, Schwab AJ, Basanez M-G, Prichard RKet al., 2007,

  An analysis of the population genetics of potential multi-drug resistance in <i>Wuchereria bancrofti</i> due to combination chemotherapy

  , PARASITOLOGY, Vol: 134, Pages: 1025-1040, ISSN: 0031-1820
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  • Citations: 50
• Journal article
  Trotter C, Findlow J, Balmer P, Holland A, Barchha R, Hamer N, Andrews N, Miller E, Borrow Ret al., 2007,

  Seroprevalence of bactericidal and anti-outer membrane vesicle antibodies to <i>Neisseria meningitildis</i> group B in England

  , CLINICAL AND VACCINE IMMUNOLOGY, Vol: 14, Pages: 863-868, ISSN: 1556-6811
  • Cite
  • Citations: 41
• Journal article
  Ster IC, Ferguson NM, 2007,

  Transmission Parameters of the 2001 Foot and Mouth Epidemic in Great Britain

  , PLOS ONE, Vol: 2, ISSN: 1932-6203
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  • Citations: 79
• Journal article
  White RG, Cooper BS, Kedhar A, Orroth KK, Biraro S, Baggaley RF, Whitworth J, Korenromp EL, Ghani A, Boily M-C, Hayes RJet al., 2007,

  Quantifying HIV-1 transmission due to contaminated injections

  , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 9794-9799, ISSN: 0027-8424
  • Author Web Link
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  • Citations: 19
• Journal article
  Gras L, Kesselring AM, Griffin JT, van Sighem AI, Fraser C, Ghani AC, Miedema F, Reiss P, Lange JMA, de Wolf Fet al., 2007,

  CD4 cell counts of 800 cells/mm<SUP>3</SUP> or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm<SUP>3</SUP> or greater

  , JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 45, Pages: 183-192, ISSN: 1525-4135
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  • Citations: 133

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