Publications

Search or filter publications

Search publications Search

Filter by type:

Filter by publication type

• Book
• Book chapter
• Conference paper
• Journal article
• Other
• Patent
• Poster
• Report
• Scholarly edition
• Software
• Thesis dissertation
• Working paper

Filter by year:

Filter from 202520242023202220212020201920182017201620152014201320122011201020092008200720062005200420032002200120001999199819971996199519941993199219911990198919881987198619851984198319821981198019791978197719761975197419731972 to Filter to 202520242023202220212020201920182017201620152014201320122011201020092008200720062005200420032002200120001999199819971996199519941993199219911990198919881987198619851984198319821981198019791978197719761975197419731972

---

Search results

• Journal article
  Boily MC, Lowndes CM, Gregson S, 2002,

  Population-level risk factors for HIV transmission and 'the 4 Cities Study': temporal dynamics and the significance of sexual mixing patterns

  , AIDS, Vol: 16, Pages: 2101-2102, ISSN: 0269-9370
  • Author Web Link
  • Cite
  • Citations: 15
• Journal article
  Gregson S, 2002,

  Erratum: Sexual mixing patterns and sex-differentials in teenage exposure to HIV infection in rural Zimbabwe (Lancet (June 1) (1896))

  , Lancet, Vol: 360, ISSN: 0140-6736
  • Cite
  • Citations: 4
• Journal article
  Gregson S, Zhuwau T, Ndlovu J, Nyamukapa CAet al., 2002,

  Methods to reduce social desirability bias in sex surveys in low-development settings - Experience in Zimbabwe

  , SEXUALLY TRANSMITTED DISEASES, Vol: 29, Pages: 568-575, ISSN: 0148-5717
  • Author Web Link
  • Cite
  • Citations: 144
• Journal article
  Whittaker CA, Hynes RO, 2002,

  Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.

  , Mol Biol Cell, Vol: 13, Pages: 3369-3387, ISSN: 1059-1524

  The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins, and in integrin receptors. A number of human diseases arise from mutations in VWA domains. We have analyzed the phylogenetic distribution of this domain and the relationships among approximately 500 proteins containing this domain. Although the majority of VWA-containing proteins are extracellular, the most ancient ones, present in all eukaryotes, are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport, and the proteasome. A common feature seems to be involvement in multiprotein complexes. Subsequent evolution involved deployment of VWA domains by Metazoa in extracellular proteins involved in cell adhesion such as integrin beta subunits (all Metazoa). Nematodes and chordates separately expanded their complements of extracellular matrix proteins containing VWA domains, whereas plants expanded their intracellular complement. Chordates developed VWA-containing integrin alpha subunits, collagens, and other extracellular matrix proteins (e.g., matrilins, cochlin/vitrin, and von Willebrand factor). Consideration of the known properties of VWA domains in integrins and extracellular matrix proteins allows insights into their involvement in protein-protein interactions and the roles of bound divalent cations and conformational changes. These allow inferences about similar functions in novel situations such as protease regulators (e.g., complement factors and trypsin inhibitors) and intracellular proteins (e.g., helicases, chelatases, and copines).

  • Abstract
  • Author Web Link
  • Cite
• Journal article
  Trotter CL, Fox AJ, Ramsay ME, Sadler F, Gray SJ, Mallard R, Kaczmarski EBet al., 2002,

  Fatal outcome from meningococcal disease--an association with meningococcal phenotype but not with reduced susceptibility to benzylpenicillin.

  , J Med Microbiol, Vol: 51, Pages: 855-860, ISSN: 0022-2615

  Penicillin has been the mainstay of treatment for meningococcal disease. Isolates of Neisseria meningitidis that are less susceptible to penicillin have been reported in several countries and in recent years have become more common. The clinical significance of this reduced susceptibility has not been investigated on a large scale. Hence, N. meningitidis isolates from culture-confirmed cases of meningococcal disease in England and Wales, between 1993 and 2000, were routinely serogrouped, serotyped and tested for susceptibility to penicillin. These data were linked to death registrations and analysed retrospectively. The changing trends in susceptibility were described and multivariate logistic regression was used to examine associations between strain characteristics and fatal outcome. The frequency of N. meningitidis isolates less susceptible to penicillin increased from < 6% in 1993 to > 18% in 2000. In particular, isolates expressing serogroup C with serotype 2b and serogroup W135 had a higher frequency of reduced penicillin susceptibility (49% and 55%, respectively). There was no evidence of an association between fatal outcome and infection with a less penicillin-susceptible isolate. Fatal outcome was associated with serogroup and serotype, with the odds of death for cases infected with C:2a and B:2a strains three-fold higher when compared with the baseline. For this large dataset the serogroup and serotype of the infecting strain influenced mortality from meningococcal disease and may be markers for hypervirulence. No association was found between reduced penicillin susceptibility and fatal outcome, but the increasing frequency of isolates less susceptible to penicillin highlights the need for continued surveillance.

  • Abstract
  • Author Web Link
  • Cite
• Journal article
  Hilton DA, Ghani AC, Conyers L, Edwards P, McCardle L, Penney M, Ritchie D, Ironside JWet al., 2002,

  Accumulation of prion protein in tonsil and appendix: review of tissue samples

  , BRITISH MEDICAL JOURNAL, Vol: 325, Pages: 633-634, ISSN: 0959-535X
  • Author Web Link
  • Cite
  • Citations: 109
• Journal article
  Trotter CL, Ramsay ME, Kaczmarski EB, 2002,

  Meningococcal serogroup C conjugate vaccination in England and Wales: coverage and initial impact of the campaign.

  , Commun Dis Public Health, Vol: 5, Pages: 220-225, ISSN: 1462-1843

  The UK was the first country to introduce meningococcal serogroup C conjugate vaccination. The vaccine was incorporated into the routine infant immunisation schedule and was offered to all under 18 year olds in a catch-up campaign. The vaccine has been well accepted in infants receiving routine vaccination, with coverage around 89%. Coverage in older children targeted in the catch-up campaign was above 85% up to the age of 14, and was lowest (43%) in 15-17 year olds not in education. The winter of 2000-01 was the first meningococcal season following the offer of the vaccination to all children and adolescents. The incidence of serogroup C disease in the targeted age groups fell by 80%, and the number of deaths in laboratory confirmed cases in 0-19 year olds decreased from 78 to 8 between 1998-99 and 2000-01. The incidence of serogroup B disease in all age groups was slightly higher in 2000-01 than previous years, and there was an increase in the incidence of serogroup C disease in those aged over 20 during the study period, leading to the extension of the vaccination campaign to 20-24 year olds.

  • Abstract
  • Author Web Link
  • Cite
• Journal article
  Mckee D, Hatton K, Eaton JW, Atkinson D, Atherton A, Harvey I, Moss Bet al., 2002,

  Effects of simulated climate warming on macrophytes in freshwater microcosm communities

  , AQUATIC BOTANY, Vol: 74, Pages: 71-83, ISSN: 0304-3770
  • Cite
• Journal article
  Davison KL, Ramsay ME, Crowcroft NS, Lieftucht A, Kaczmarski EB, Trotter CL, Gungabissoon U, Begg NTet al., 2002,

  Estimating the burden of serogroup C meningococcal disease in England and Wales.

  , Commun Dis Public Health, Vol: 5, Pages: 213-219, ISSN: 1462-1843

  In 1999 a new conjugate vaccine for serogroup C meningococcal disease was licensed for use in the UK. In order for an appropriate vaccination strategy to be developed the burden of serogroup C disease in England and Wales needed to be established. This was done using data from an enhanced surveillance scheme alongside routine laboratory reports and a total of 5,052 cases of serogroup C disease in England and Wales between 1993 and 1998 were estimated. Among these, an estimated 398 died and 1,767 were admitted to intensive care units (ITUs). The greatest burden of disease was in young children and teenagers. The current literature identified four studies reporting sequelae following serogroup C meningococcal disease. These provided estimates of sequelae in the range of 6.5% and 45% and presented some evidence of higher levels than occur following serogroup B meningococcal disease. This information was provided to the Joint Committee on Vaccination and Immunisation to inform policy to implement a serogroup C conjugate vaccination programme in the UK. The vaccination programme has since been justified by the dramatic reduction in serogroup C meningococcal cases.

  • Abstract
  • Author Web Link
  • Cite
• Journal article
  Howard SC, Donnelly CA, Kabatereine NB, Ratard RC, Brooker Set al., 2002,

  Spatial and intensity-dependent variations in associations between multiple species helminth infections

  , ACTA TROPICA, Vol: 83, Pages: 141-149, ISSN: 0001-706X
  • Author Web Link
  • Cite
  • Citations: 24

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.