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• Journal article
  Grillet M-E, Villamizar NJ, Frontado HL, Cortez J, Escalona M, Botto C, Basanez M-Get al., 2008,

  Vector competence of <i>Simulium oyapockense</i> s.l. and <i>S</i>. <i>incrustatum</i> for <i>Onchocerca volvulus</i>:: Implications for ivermectin-based control in the Amazonian focus of human onchocerciasis, a multi-vector-host system

  , ACTA TROPICA, Vol: 107, Pages: 80-89, ISSN: 0001-706X
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  • Citations: 9
• Journal article
  MacInnes AW, Amsterdam A, Whittaker CA, Hopkins N, Lees JAet al., 2008,

  Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations.

  , Proc Natl Acad Sci U S A, Vol: 105, Pages: 10408-10413

  Zebrafish carrying heterozygous mutations for 17 different ribosomal protein (rp) genes are prone to developing malignant peripheral nerve sheath tumors (MPNSTs), a tumor type that is seldom seen in laboratory strains of zebrafish. Interestingly, the same rare tumor type arises in zebrafish that are homozygous for a loss-of-function point mutation in the tumor suppressor gene p53. For these reasons, and because p53 is widely known to be mutated in the majority of human cancers, we investigated the status of p53 in the rp(+/-) MPNSTs. Using monoclonal antibodies that we raised to zebrafish p53, we found that cells derived from rp(+/-) MPNSTs are significantly impaired in their ability to produce p53 protein even in the presence of a proteasome inhibitor and gamma-irradiation. Although the coding regions of the p53 gene remain wild type, the gene is transcribed, and overall protein production rates appear normal in rp(+/-) MPNST cells, p53 protein does not get synthesized. This defect is observed in all MPNSTs we examined that were derived from our 17 zebrafish lines with rp gene mutations. To date, studies of p53 in malignancies have focused predominantly on either p53 gene mutations or the aberrant posttranslational regulation of the p53 protein. Our results show that the appropriate amount of numerous ribosomal proteins is required for p53 protein production in vivo and that disruption of this regulation most likely contributes to tumorigenesis.

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• Journal article
  Baggaley RF, White RG, Boily M-C, 2008,

  Systematic review of orogenital HIV-1 transmission probabilities

  , International Journal of Epidemiology, Vol: 37, Pages: 1255-1265, ISSN: 1464-3685

  Background The objective was to assess the risk of HIV transmission from orogenital intercourse (OI).Methods Systematic review of the literature on HIV-1 infectiousness through OI conducted according to MOOSE guidelines for reviews of observational studies. The PubMed database and bibliographies of relevant articles were searched to July 2007.Results Of the titles, 56 214 were searched from which 10 potentially appropriate studies were identified; two additional studies were identified through bibliographies and one through discussion with experts. There were 10 included studies, providing estimates of transmission probabilities per-partner (n = 5), incidence per-partner (n = 3), per-study participant (n = 3, following initially seronegative individuals whose partners are of unknown serostatus) and per-act (n = 3). Only four of 10 studies reported non-zero estimates: two per-partner estimates (20%, 95% CI: 6–51, n = 10 and a model-based estimate, 1%, range 0.85–2.3%), one per-study participant estimate (0.37%, 95% CI: 0.10–1.34%) and one per-act estimate (0.04%, 95% CI: 0.01–0.17%). Upper bounds for the 95% CI for zero estimates tended to be relatively large due to the small study sample sizes: 9.0, 12.1 and 2.8% for per-partner; 4.7, 9.6 and 1.8 per 100 person-years for incidence per-partner; 4.4% per-study participant and 0.45 and 0.02% for per-act. Given the small number of studies, a meta-analysis was not considered appropriate.Conclusions There are currently insufficient data to estimate precisely the risk from OI exposure. The low risk of transmission evident from identified studies means that more and larger studies would be required to provide sufficient evidence to derive more precise estimates.

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• Journal article
  Garske T, Rhodes CJ, 2008,

  The effect of superspreading on epidemic outbreak size distributions

  , JOURNAL OF THEORETICAL BIOLOGY, Vol: 253, Pages: 228-237, ISSN: 0022-5193
  • Author Web Link
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  • Citations: 46
• Journal article
  Jombart T, Devillard S, Dufour A-B, Pontier Det al., 2008,

  Revealing cryptic spatial patterns in genetic variability by a new multivariate method

  , HEREDITY, Vol: 101, Pages: 92-103, ISSN: 0018-067X
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  • Citations: 474
• Journal article
  Bell JS, Ouedraogo M, Ganaba R, Sombie I, Byass P, Baggaley RF, Filippi V, Fitzmaurice AE, Graham WJet al., 2008,

  The epidemiology of pregnancy outcomes in rural Burkina Faso

  , TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 13, Pages: 31-43, ISSN: 1360-2276
  • Author Web Link
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  • Citations: 26
• Journal article
  Arinaminpathy N, McLean AR, 2008,

  Antiviral treatment for the control of pandemic influenza: some logistical constraints

  , JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 5, Pages: 545-553, ISSN: 1742-5689
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  • Citations: 31
• Journal article
  Jombart T, 2008,

  <i>adegenet</i>: a R package for the multivariate analysis of genetic markers

  , BIOINFORMATICS, Vol: 24, Pages: 1403-1405, ISSN: 1367-4803
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  • Citations: 6336
• Journal article
  Grassly NC, Fraser C, 2008,

  Mathematical models of infectious disease transmission

  , NATURE REVIEWS MICROBIOLOGY, Vol: 6, Pages: 477-487, ISSN: 1740-1526
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  • Citations: 450
• Journal article
  Volz E, 2008,

  Susceptible-infected-recovered epidemics in populations with heterogeneous contact rates

  , EUROPEAN PHYSICAL JOURNAL B, Vol: 63, Pages: 381-386, ISSN: 1434-6028
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  • Citations: 10

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