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• Journal article
  Rambaut A, Grassly NC, Nee S, Harvey PHet al., 1996,

  Bi-De: An application for simulating phylogenetic processes

  , COMPUTER APPLICATIONS IN THE BIOSCIENCES, Vol: 12, Pages: 469-471, ISSN: 0266-7061
  • Author Web Link
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  • Citations: 24
• Journal article
  Williams JR, Nokes DJ, Anderson RM, 1996,

  Targeted hepatitis B vaccination - A cost effective immunisation strategy for the UK?

  , JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 50, Pages: 667-673, ISSN: 0143-005X
  • Author Web Link
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  • Citations: 28
• Journal article
  Nowak MA, Anderson RM, Boerlijst MC, Bonhoeffer S, May RM, McMichael AJet al., 1996,

  HIV-1 evolution and disease progression

  , SCIENCE, Vol: 274, Pages: 1008-1010, ISSN: 0036-8075
  • Author Web Link
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  • Citations: 70
• Journal article
  Anderson RM, Garnett GP, 1996,

  Low-efficacy HIV vaccines: Potential for community-based intervention programmes

  , LANCET, Vol: 348, Pages: 1010-1013, ISSN: 0140-6736
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  • Citations: 70
• Journal article
  Basanez MG, Townson H, Williams JR, Frontado H, Villamizar NJ, Anderson RMet al., 1996,

  Density-dependent processes in the transmission of human onchocerciasis: Relationship between microfilarial intake and mortality of the simuliid vector

  , PARASITOLOGY, Vol: 113, Pages: 331-355, ISSN: 0031-1820
  • Author Web Link
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  • Citations: 39
• Journal article
  Garnett GP, Anderson RM, 1996,

  Sexually transmitted diseases and sexual behavior: Insights from mathematical models

  , JOURNAL OF INFECTIOUS DISEASES, Vol: 174, Pages: S150-S161, ISSN: 0022-1899
  • Author Web Link
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  • Citations: 117
• Journal article
  Williams JR, Nokes DJ, Medley GF, Anderson RMet al., 1996,

  The transmission dynamics of hepatitis B in the UK: A mathematical model for evaluating costs and effectiveness of immunization programmes (vol 116, pg 71, 1996)

  , EPIDEMIOLOGY AND INFECTION, Vol: 117, Pages: 409-409, ISSN: 0950-2688
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• Journal article
  Chan MS, Anderson RM, Medley GF, Bundy DAPet al., 1996,

  Dynamic aspects of morbidity and acquired immunity in schistosomiasis control

  , ACTA TROPICA, Vol: 62, Pages: 105-117, ISSN: 0001-706X
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  • Citations: 21
• Journal article
  Ramos JW, Whittaker CA, DeSimone DW, 1996,

  Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation.

  , Development, Vol: 122, Pages: 2873-2883, ISSN: 0950-1991

  Integrins mediate cell-ECM interactions essential for morphogenesis, however, the extent to which integrin adhesive activities are regulated in the embryo has not been addressed. We report that integrin-dependent cell adhesion to the Arg-Gly-Asp (RGD) containing central cell-binding domain of fibronectin is required for gastrulation in Xenopus. Although all cells of the early embryo retain the ability to attach to this region, only involuting cells arising from the dorsal and ventral lips of the blastopore are able to spread and migrate on fibronectin in vitro. This change in adhesive behavior is mimicked by treating animal cap cells with activin-A. Activin-induced changes in adhesion are independent of new transcription, translation, or changes in receptor expression at the cell surface. We demonstrate that ectopic expression of integrin alpha4beta1 in animal cap cells results in attachment to the non RGD-containing V-region of fibronectin. Further, these cells acquire the ability to spread on the V-region following activin induction. Thus, alpha4beta1 adhesion to the V-region, like endogenous integrin binding to the central cell-binding domain, is responsive to activin signalling. These data indicate that cell adhesion to the central cell-binding domain is regulated in both space and time, and is under the control of inductive signals that initiate gastrulation movements. We suggest that position-specific inductive interactions are likely to represent a novel and general mechanism by which integrin adhesion is modulated throughout development.

  • Abstract
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• Journal article
  Austin DJ, Anderson RM, 1996,

  Immunodominance, competition and evolution in immunological responses to helminth parasite antigens

  , PARASITOLOGY, Vol: 113, Pages: 157-172, ISSN: 0031-1820
  • Author Web Link
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  • Citations: 12

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