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  • Journal article
    Riley S, Fraser C, Donnelly CA, Ghani AC, Abu-Raddad LJ, Hedley AJ, Leung GM, Ho L-M, Lam T-H, Thach TQ, Chau P, Chan K-P, Lo S-V, Leung P-Y, Tsang T, Ho W, Lee K-H, Lau EMC, Ferguson NM, Anderson RMet al., 2003,

    Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions

    , Science, Vol: 300, Pages: 1961-1966
  • Conference paper
    Fraser C, Anderson RM, 2003,

    HIV viral sex: inbreeding, recombination, drug resistance and clinical outcome

    , 12th International HIV Drug Resistance Workshop, Publisher: INT MEDICAL PRESS LTD, Pages: U68-U69, ISSN: 1359-6535
  • Journal article
    Demanou M, Enyong P, Pion SDS, Basáñez MG, Boussinesq Met al., 2003,

    Experimental studies on the transmission of <i>Onchocerca volvulus</i> by its vector in the Sanaga valley (Cameroon):: <i>Simulium squamosum</i> B.: Intake of microfilariae and their migration to the haemocoel of the vector

    , ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, Vol: 97, Pages: 381-402, ISSN: 0003-4983
  • Conference paper
    Raboud JM, Boily MC, Rajeswaran J, O'Shaughnessy MV, Schechter MTet al., 2003,

    The impact of needle-exchange programs on the spread of HIV among injection drug users: a simulation study

    , Conference on Statistics and Health, Publisher: SPRINGER, Pages: 302-320, ISSN: 1099-3460
    • Cite
    • Citations: 21
  • Journal article
    Donnelly CA, Ghani AC, Leung GM, 2003,

    Erratum: Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong (Lancet (2003) 361 (1761-1766))

    , Lancet, Vol: 361, ISSN: 0140-6736
  • Journal article
    Donnelly CA, Ghani AC, Leung GM, 2003,

    Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong (vol 361, pg 1761, 2003)

    , LANCET, Vol: 361, Pages: 1832-1832, ISSN: 0140-6736
    • Cite
    • Citations: 18
  • Journal article
    Donnelly CA, Ghani AC, Leung GM, Hedley AJ, Fraser C, Riley S, Abu-Raddad LJ, Ho L-M, Thach T-Q, Chau P, Chan K-P, Lam T-H, Tse L-Y, Tsang T, Liu S-H, Kong JHB, Lau EMC, Ferguson NM, Anderson RMet al., 2003,

    Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong

    , The Lancet, Vol: 361, Pages: 1761-1766, ISSN: 0140-6736

    BackgroundHealth authorities worldwide, especially in the Asia Pacific region, are seeking effective public-health interventions in the continuing epidemic of severe acute respiratory syndrome (SARS). We assessed the epidemiology of SARS in Hong Kong.MethodsWe included 1425 cases reported up to April 28, 2003. An integrated database was constructed from several sources containing information on epidemiological, demographic, and clinical variables. We estimated the key epidemiological distributions: infection to onset, onset to admission, admission to death, and admission to discharge. We measured associations between the estimated case fatality rate and patients’age and the time from onset to admission.FindingsAfter the initial phase of exponential growth, the rate of confirmed cases fell to less than 20 per day by April 28. Public-health interventions included encouragement to report to hospital rapidly after the onset of clinical symptoms, contact tracing for confirmed and suspected cases, and quarantining, monitoring, and restricting the travel of contacts. The mean incubation period of the disease is estimated to be 6.4 days (95% Cl 5.2–7.7). The mean time from onset of clinical symptoms to admission to hospital varied between 3 and 5 days, with longer times earlier in the epidemic. The estimated case fatality rate was 13.2% (9.8–16.8) for patients younger than 60 years and 43.3% (35.2–52.4) for patients aged 60 years or older assuming a parametric γ distribution. A non-parametric method yielded estimates of 6.8% (4.0–9.6) and 55.0% (45.3–64.7), respectively. Case clusters have played an important part in the course of the epidemic.InterpretationPatients’age was strongly associated with outcome. The time between onset of symptoms and admission to hospital did not alter outcome, but shorter intervals will be important to the wider population by restricting the infectious period before patients are placed in quaranti
  • Journal article
    Gay NJ, Andrews NJ, Trotter CL, Edmunds WJet al., 2003,

    Estimating deaths due to influenza and respiratory syncytial virus

    , JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 289, Pages: 2499-2499, ISSN: 0098-7484
    • Cite
    • Citations: 18
  • Journal article
    Trotter CL, McVernon J, Andrews NJ, Burrage M, Ramsay MEet al., 2003,

    Antibody to <i>Haemophilus influenzae</i> type b after routine and catch-up vaccination

    , LANCET, Vol: 361, Pages: 1523-1524, ISSN: 0140-6736
    • Cite
    • Citations: 55
  • Journal article
    Grassly NC, Desai K, Pegurri E, Sikazwe A, Malambo I, Siamatowe C, Bundy Det al., 2003,

    The economic impact of HIV/AIDS on the education sector in Zambia

    , AIDS, Vol: 17, Pages: 1039-1044, ISSN: 0269-9370
    • Cite
    • Citations: 17

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