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  • Journal article
    Trotter CL, Ramsay ME, Kaczmarski EB, 2002,

    Meningococcal serogroup C conjugate vaccination in England and Wales: coverage and initial impact of the campaign.

    , Commun Dis Public Health, Vol: 5, Pages: 220-225, ISSN: 1462-1843

    The UK was the first country to introduce meningococcal serogroup C conjugate vaccination. The vaccine was incorporated into the routine infant immunisation schedule and was offered to all under 18 year olds in a catch-up campaign. The vaccine has been well accepted in infants receiving routine vaccination, with coverage around 89%. Coverage in older children targeted in the catch-up campaign was above 85% up to the age of 14, and was lowest (43%) in 15-17 year olds not in education. The winter of 2000-01 was the first meningococcal season following the offer of the vaccination to all children and adolescents. The incidence of serogroup C disease in the targeted age groups fell by 80%, and the number of deaths in laboratory confirmed cases in 0-19 year olds decreased from 78 to 8 between 1998-99 and 2000-01. The incidence of serogroup B disease in all age groups was slightly higher in 2000-01 than previous years, and there was an increase in the incidence of serogroup C disease in those aged over 20 during the study period, leading to the extension of the vaccination campaign to 20-24 year olds.
  • Journal article
    Davison KL, Ramsay ME, Crowcroft NS, Lieftucht A, Kaczmarski EB, Trotter CL, Gungabissoon U, Begg NTet al., 2002,

    Estimating the burden of serogroup C meningococcal disease in England and Wales.

    , Commun Dis Public Health, Vol: 5, Pages: 213-219, ISSN: 1462-1843

    In 1999 a new conjugate vaccine for serogroup C meningococcal disease was licensed for use in the UK. In order for an appropriate vaccination strategy to be developed the burden of serogroup C disease in England and Wales needed to be established. This was done using data from an enhanced surveillance scheme alongside routine laboratory reports and a total of 5,052 cases of serogroup C disease in England and Wales between 1993 and 1998 were estimated. Among these, an estimated 398 died and 1,767 were admitted to intensive care units (ITUs). The greatest burden of disease was in young children and teenagers. The current literature identified four studies reporting sequelae following serogroup C meningococcal disease. These provided estimates of sequelae in the range of 6.5% and 45% and presented some evidence of higher levels than occur following serogroup B meningococcal disease. This information was provided to the Joint Committee on Vaccination and Immunisation to inform policy to implement a serogroup C conjugate vaccination programme in the UK. The vaccination programme has since been justified by the dramatic reduction in serogroup C meningococcal cases.
  • Journal article
    Mckee D, Hatton K, Eaton JW, Atkinson D, Atherton A, Harvey I, Moss Bet al., 2002,

    Effects of simulated climate warming on macrophytes in freshwater microcosm communities

    , AQUATIC BOTANY, Vol: 74, Pages: 71-83, ISSN: 0304-3770
  • Journal article
    Howard SC, Donnelly CA, Kabatereine NB, Ratard RC, Brooker Set al., 2002,

    Spatial and intensity-dependent variations in associations between multiple species helminth infections

    , ACTA TROPICA, Vol: 83, Pages: 141-149, ISSN: 0001-706X
  • Journal article
    Glatzel M, Rogivue C, Ghani A, Streffer JR, Amsler L, Aguzzi Aet al., 2002,

    Incidence of Creutzfeldt-Jakob disease in Switzerland

    , LANCET, Vol: 360, Pages: 139-141, ISSN: 0140-6736
  • Journal article
    Stover J, Walker N, Garnett GP, Salomon JA, Stanecki KA, Ghys PD, Grassly NC, Anderson RM, Schwartländer Bet al., 2002,

    Can we reverse the HIV/AIDS pandemic with an expanded response?

    , LANCET, Vol: 360, Pages: 73-77, ISSN: 0140-6736
  • Journal article
    Garnett GP, Bartley L, Grassly NC, Anderson RMet al., 2002,

    Antiretroviral therapy to treat and prevent HIV/AIDS in resource-poor settings

    , NATURE MEDICINE, Vol: 8, Pages: 651-654, ISSN: 1078-8956
    • Cite
    • Citations: 26
  • Journal article
    Donnelly CA, 2002,

    BSE in France: epidemiological analysis and predictions

    , COMPTES RENDUS BIOLOGIES, Vol: 325, Pages: 793-806, ISSN: 1631-0691
  • Journal article
    Ghani AC, Ferguson NM, Fraser C, Donnelly CA, Danner S, Reiss P, Lange J, Goudsmit J, Anderson RM, De Wolf Fet al., 2002,

    Viral replication under combination antiretroviral therapy: A comparison of four different regimens

    , JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 30, Pages: 167-176, ISSN: 1525-4135
    • Cite
    • Citations: 13
  • Journal article
    Gregson S, Nyamukapa CA, Garnett GP, Mason PR, Zhuwau T, Caraël M, Chandiwana SK, Anderson RMet al., 2002,

    Sexual mixing patterns and sex-differentials in teenage exposure to HIV infection in rural Zimbabwe

    , LANCET, Vol: 359, Pages: 1896-1903, ISSN: 0140-6736

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