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  • Conference paper
    Wearden ME, Brunk UT, Terman A, Eaton JWet al., 2000,

    Mitochondria: Potential importance in hyperoxic lung injury

    , Publisher: INT PEDIATRIC RESEARCH FOUNDATION, INC, Pages: 380A-380A, ISSN: 0031-3998
  • Journal article
    Thomas DD, Donnelly CA, Wood RJ, Alphey LSet al., 2000,

    Insect population control using a dominant, repressible, lethal genetic system

    , SCIENCE, Vol: 287, Pages: 2474-2476, ISSN: 0036-8075
  • Journal article
    Mason PR, Gwanzura L, Gregson S, Katzenstein DAet al., 2000,

    Chlamydia trachomatis in symptomatic and asymptomatic men: detection in urine by enzyme immunoassay.

    , Cent Afr J Med, Vol: 46, Pages: 62-65, ISSN: 0008-9176

    BACKGROUND: Infection with Chlamydia trachomatis is known to be a common cause of urethritis and cervicitis. The standard methods of detection require the collection of intra-urethral and/or cervical swabs, which may be submitted for culture, antigen detection or nucleic acid amplification. The collection of swabs is suitable only within the context of a health care facility. Recent reports have indicated that antigen detection can be used with urine specimens, and because these can be self-collected, this may be particularly useful for the detection of asymptomatic carriage. OBJECTIVE: To determine the sensitivity and specificity of urine antigen assays in the detection of chlamydial infection in men. SETTING: Two groups of men were investigated; men with urethritis attending clinics or private practitioners, and healthy adult men enrolled into either urban or rural HIV prevention projects. METHODS: Urine samples from men in both groups were collected and assayed for the presence of chlamydial antigen using a commercial enzyme immunoassay (EIA) kit. For symptomatic men an intra-urethral swab was also collected and assayed for antigen detection using a commercial EIA. For asymptomatic men, a ligase chain reaction was carried out on the same urine sample. RESULTS: The prevalence of chlamydial antigen in symptomatic men was 15% (39/257), and in asymptomatic men was 4% (15/349). The sensitivity and specificity of urine EIA for symptomatic men was 87% and 83% respectively. For asymptomatic men, the sensitivity of urine EIA was 86%, and the specificity was 100%. CONCLUSION: Urine EIA is a relatively inexpensive method for the detection of chlamydial infections in men. The true specificity in symptomatic men may be higher, as the "gold standard" that we used may give false negative results. Antigen EIA for examination of urine specimens from community surveys of asymptomatic men may be particularly useful because of the low cost of assays, and because urine samp
  • Journal article
    Garnett GP, Bartley LM, Cameron DW, Anderson RMet al., 2000,

    Both a 'magic bullet' and good aim are required to link public health interests and health care needs in HIV infection

    , NATURE MEDICINE, Vol: 6, Pages: 261-262, ISSN: 1078-8956
  • Journal article
    Morrison WI, Bourne FJ, Cox DR, Donnelly CA, Gettinby G, Mcinerney JP, Woodroffe Ret al., 2000,

    Pathogenesis and diagnosis of infections with Mycobacterium bovis in cattle

    , Veterinary Record, Vol: 146, Pages: 236-242, ISSN: 0042-4900

    In last week's Veterinary Record, members of the Independent Scientific Group on Cattle TB discussed the approach they are adopting in attempting to develop sustainable strategies for controlling bovine tuberculosis in cattle (VR, February 19, pp 207-210). In this second, complementary article, they consider the extent to which efforts to control the disease may be constrained by limitations in current testing procedures.
  • Journal article
    Morrison WI, Bourne FJ, Cox DR, Donnelly CA, Gettinby G, McInerney JP, Woodroffe Ret al., 2000,

    Pathogenesis and diagnosis of infections with <i>Mycobacterium bovis</i> in cattle

    , VETERINARY RECORD, Vol: 146, Pages: 236-242, ISSN: 0042-4900
  • Journal article
    Bourne J, Donnelly CA, Cox DR, Gettinby G, McInerney JP, Morrison I, Woodroffe Ret al., 2000,

    Bovine tuberculosis: towards a future control strategy

    , VETERINARY RECORD, Vol: 146, Pages: 207-210, ISSN: 0042-4900
  • Journal article
    Bruce MC, Donnelly CA, Alpers MP, Galinski MR, Barnwell JW, Walliker D, Day KPet al., 2000,

    Cross-species interactions between malaria parasites in humans

    , SCIENCE, Vol: 287, Pages: 845-848, ISSN: 0036-8075
  • Journal article
    Basáñez MG, Yarzábal L, Frontado HL, Villamizar NJet al., 2000,

    <i>Onchocerca</i>-<i>Simulium</i> complexes in Venezuela: can human onchocerciasis spread outside its present endemic areas?

    , PARASITOLOGY, Vol: 120, Pages: 143-160, ISSN: 0031-1820
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    • Citations: 16
  • Journal article
    Jones JI, Eaton JW, Hardwick K, 2000,

    The effect of changing environmental variables in the surrounding water on the physiology of <i>Elodea nuttallii</i>

    , AQUATIC BOTANY, Vol: 66, Pages: 115-129, ISSN: 0304-3770

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