@article{Kura:2024:cid/ciae021,
author = {Kura, K and Stolk, WA and Basáñez, M-G and Collyer, BS and de, Vlas SJ and Diggle, PJ and Gass, K and Graham, M and Hollingsworth, TD and King, JD and Krentel, A and Anderson, RM and Coffeng, LE},
doi = {cid/ciae021},
journal = {Clinical Infectious Diseases},
pages = {S93--S100},
title = {How does the proportion of never treatment influence the success of mass drug administration programs for the elimination of lymphatic filariasis?},
url = {http://dx.doi.org/10.1093/cid/ciae021},
volume = {78},
year = {2024}
}

Download

TY  - JOUR
AB  - BackgroundMass drug administration (MDA) is the cornerstone for the elimination of lymphatic filariasis (LF). The proportion of the population that is never treated (NT) is a crucial determinant of whether this goal is achieved within reasonable time frames.MethodsUsing 2 individual-based stochastic LF transmission models, we assess the maximum permissible level of NT for which the 1% microfilaremia (mf) prevalence threshold can be achieved (with 90% probability) within 10 years under different scenarios of annual MDA coverage, drug combination and transmission setting.ResultsFor Anopheles-transmission settings, we find that treating 80% of the eligible population annually with ivermectin + albendazole (IA) can achieve the 1% mf prevalence threshold within 10 years of annual treatment when baseline mf prevalence is 10%, as long as NT <10%. Higher proportions of NT are acceptable when more efficacious treatment regimens are used. For Culex-transmission settings with a low (5%) baseline mf prevalence and diethylcarbamazine + albendazole (DA) or ivermectin + diethylcarbamazine + albendazole (IDA) treatment, elimination can be reached if treatment coverage among eligibles is 80% or higher. For 10% baseline mf prevalence, the target can be achieved when the annual coverage is 80% and NT ≤15%. Higher infection prevalence or levels of NT would make achieving the target more difficult.ConclusionsThe proportion of people never treated in MDA programmes for LF can strongly influence the achievement of elimination and the impact of NT is greater in high transmission areas. This study provides a starting point for further development of criteria for the evaluation of NT.
AU  - Kura,K
AU  - Stolk,WA
AU  - Basáñez,M-G
AU  - Collyer,BS
AU  - de,Vlas SJ
AU  - Diggle,PJ
AU  - Gass,K
AU  - Graham,M
AU  - Hollingsworth,TD
AU  - King,JD
AU  - Krentel,A
AU  - Anderson,RM
AU  - Coffeng,LE
DO  - cid/ciae021
EP  - 100
PY  - 2024///
SN  - 1058-4838
SP  - 93
TI  - How does the proportion of never treatment influence the success of mass drug administration programs for the elimination of lymphatic filariasis?
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/ciae021
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38662701
UR  - https://academic.oup.com/cid/article/78/Supplement_2/S93/7657839
UR  - http://hdl.handle.net/10044/1/111695
VL  - 78
ER  - 

Download