@article{Kuchukhidze:2024:10.1016/S2352-3018(24)00148-6,
author = {Kuchukhidze, S and Walters, MK and Panagiotoglou, D and Boily, M-C and Diabaté, S and Russell, WA and Stöckl, H and Sardinha, L and Mbofana, F and Wanyenze, RK and Imai-Eaton, JW and Maheu-Giroux, M},
doi = {10.1016/S2352-3018(24)00148-6},
journal = {Lancet HIV},
pages = {e542--e551},
title = {The contribution of intimate partner violence to vertical HIV transmission: a modelling analysis of 46 African countries.},
url = {http://dx.doi.org/10.1016/S2352-3018(24)00148-6},
volume = {11},
year = {2024}
}

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TY  - JOUR
AB  - BACKGROUND: Addressing gender inequities could be key to the elimination of vertical transmission of HIV. Women experiencing intimate partner violence (IPV) might be at an increased risk of vertical transmission due to their vulnerability to HIV acquisition and barriers to access to and retention in care. Sub-Saharan Africa, where IPV burden is among the highest globally, accounts for most new paediatric HIV infections. We aimed to examine the proportion of excess vertical transmission attributable to IPV in this region. METHODS: In this modelling analysis, we created a probability tree model of vertical HIV transmission among women aged 15-49 years in 46 African countries. We estimated the proportion of vertical transmission attributable to past-year physical or sexual IPV, or both, as an age-standardised population attributable fraction (PAF) and as excess vertical transmission risk per 1000 births among women experiencing IPV. We incorporated perinatal and postnatal vertical transmission among women who acquired HIV before pregnancy, during pregnancy, and during breastfeeding. Fertility, HIV prevalence, HIV incidence, antiretroviral therapy (ART) uptake, and ART retention varied in the model by women's IPV experience. The model was parameterised using UNAIDS' 2023 Spectrum model data, WHO's Global Database on Violence Against Women, and the peer-reviewed literature. Uncertainty intervals (95% UI) were calculated through 1000 Monte Carlo simulations. FINDINGS: Across 46 countries 13% (95% UI 6-21) of paediatric HIV infections in 2022 were attributed to IPV, corresponding to over 22 000 paediatric infections. The PAF ranged from 4% (2-7) in Niger to 28% (13-43) in Uganda. The PAF was highest among girls aged 15-19 years (20%, 8-33) and lowest among women aged 45-49 years (6%, 3-9). In southern Africa, where women's HIV prevalence is highest (23%), IPV led to 11 (5-20) additional infections per 1000 births among women affected by IPV. INTERPRETATION: IPV migh
AU  - Kuchukhidze,S
AU  - Walters,MK
AU  - Panagiotoglou,D
AU  - Boily,M-C
AU  - Diabaté,S
AU  - Russell,WA
AU  - Stöckl,H
AU  - Sardinha,L
AU  - Mbofana,F
AU  - Wanyenze,RK
AU  - Imai-Eaton,JW
AU  - Maheu-Giroux,M
DO  - 10.1016/S2352-3018(24)00148-6
EP  - 551
PY  - 2024///
SP  - 542
TI  - The contribution of intimate partner violence to vertical HIV transmission: a modelling analysis of 46 African countries.
T2  - Lancet HIV
UR  - http://dx.doi.org/10.1016/S2352-3018(24)00148-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/39059403
VL  - 11
ER  - 

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