In this section
@article{Milne:2024:pnasnexus/pgae471,
author = {Milne, GC and Oettle, RC and Whittaker, C and Kabatereine, NB and Basáñez, M-G and Webster, JP and Walker, M and Wilson, S},
doi = {pnasnexus/pgae471},
journal = {PNAS Nexus},
title = {Revisiting immunity vs. exposure in schistosomiasis: a mathematical modeling study of delayed concomitant immunity},
url = {http://dx.doi.org/10.1093/pnasnexus/pgae471},
volume = {3},
year = {2024}
}
TY - JOUR
AB - The relative contributions of exposure vs. acquired immunity to the epidemiology of human schistosomiasis has been long debated. While there is considerable evidence that humans acquire partial immunity to infection, age- and sex-related contact patterns with water bodies contaminated with infectious cercarial schistosome larvae also contribute to typical epidemiological profiles of infection. Here, we develop a novel schistosome transmission model that incorporates both partially protective “delayed concomitant” acquired immunity—stimulated by dying worms—and host age- and sex-dependent patterns of exposure. We use a contemporary Bayesian approach to fit the model to historical individual data on exposure to infectious cercaria, eggs per gram of feces, and immunoglobulin E antibodies specific to Schistosoma mansoni Tegumental-Allergen-Like protein 1 collected from a highly endemic community in Uganda, estimating the relative contributions of exposure and acquired immunity. We find that model variants incorporating or omitting delayed concomitant immunity describe equally well the age- and sex-specific immunoepidemiological patterns observed before intervention and 18 months after treatment. Over longer time horizons, we find that acquired immunity creates subtle differences in immunoepidemiological profiles during routine mass drug administration that may confer resilience against elimination. We discuss our findings in the broader context of the immunoepidemiology of schistosomiasis.
AU - Milne,GC
AU - Oettle,RC
AU - Whittaker,C
AU - Kabatereine,NB
AU - Basáñez,M-G
AU - Webster,JP
AU - Walker,M
AU - Wilson,S
DO - pnasnexus/pgae471
PY - 2024///
SN - 2752-6542
TI - Revisiting immunity vs. exposure in schistosomiasis: a mathematical modeling study of delayed concomitant immunity
T2 - PNAS Nexus
UR - http://dx.doi.org/10.1093/pnasnexus/pgae471
UR - http://hdl.handle.net/10044/1/115529
VL - 3
ER -
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