BibTex format
@article{Sovi:2024:10.1016/s2542-5196(24)00232-8,
author = {Sovi, A and Adoha, CJ and Yovogan, B and Cross, CL and Dee, DP and Konkon, AK and Sidick, A and Accrombessi, M and Ahouandjinou, MJ and Ossè, R and Dangbénon, E and Towakinou, L and Agbangla, C and Padonou, GG and Churcher, TS and Ngufor, C and Cook, J and Protopopoff, N and Akogbéto, MC and Messenger, LA},
doi = {10.1016/s2542-5196(24)00232-8},
journal = {The Lancet Planetary Health},
pages = {e894--e905},
title = {The effect of next-generation, dual-active-ingredient, long-lasting insecticidal net deployment on insecticide resistance in malaria vectors in Benin: results of a 3-year, three-arm, cluster-randomised, controlled trial},
url = {http://dx.doi.org/10.1016/s2542-5196(24)00232-8},
volume = {8},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundInsecticide resistance among malaria vector species now occurs in 84 malaria-endemic countries and territories worldwide. Novel vector-control interventions, including long-lasting insecticidal nets (LLINs) that incorporate new active ingredients with distinct modes of action, are urgently needed to delay the evolution and spread of resistance and to alleviate reversals in malaria-control gains. We aimed to assess the longitudinal effect of two dual-active-ingredient LLINs on insecticide resistance during a cluster-randomised, controlled trial in Benin.MethodsThis 3-year, three-arm, cluster-randomised, controlled trial was conducted between Oct 17, 2019, and Oct 24, 2022, in three districts in southern Benin, to compare the effects of LLINs containing chlorfenapyr–pyrethroid or pyriproxyfen–pyrethroid with LLINs containing pyrethroid only. In 19292 mosquitoes (Anopheles gambiae sensu lato) collected over 36 months—3 months of baseline followed by 3 years post-intervention—we measured longitudinal phenotypic insecticide resistance profiles using bioassays and genotypic resistance profiles using quantitative, real-time, reverse transcriptase PCR of metabolic resistance genes in two clusters per trial group. The trial was registered with ClinicalTrials.gov, NCT03931473.FindingsIn all three trial groups, a significant effect of LLINs on insecticide resistance selection was evident, with the median lethal dose (LD50) of α-cypermethrin approximately halving between baseline and 12 months post-LLIN distribution (pyrethroid-only LLIN cluster 21: LD50 78·78 μg/ml [95% CI 65·75–94·48] vs 35·93 [29·41–43.86] and cluster 31: 79·26 [65·40–96·44] vs 38·71 [30·88–48·53]; chlorfenapyr–pyrethroid LLIN cluster 43: 104·30 [82·97–133·58] vs 43·99 [35·30–54·86]; and pyriproxyfen–
AU - Sovi,A
AU - Adoha,CJ
AU - Yovogan,B
AU - Cross,CL
AU - Dee,DP
AU - Konkon,AK
AU - Sidick,A
AU - Accrombessi,M
AU - Ahouandjinou,MJ
AU - Ossè,R
AU - Dangbénon,E
AU - Towakinou,L
AU - Agbangla,C
AU - Padonou,GG
AU - Churcher,TS
AU - Ngufor,C
AU - Cook,J
AU - Protopopoff,N
AU - Akogbéto,MC
AU - Messenger,LA
DO - 10.1016/s2542-5196(24)00232-8
EP - 905
PY - 2024///
SN - 2542-5196
SP - 894
TI - The effect of next-generation, dual-active-ingredient, long-lasting insecticidal net deployment on insecticide resistance in malaria vectors in Benin: results of a 3-year, three-arm, cluster-randomised, controlled trial
T2 - The Lancet Planetary Health
UR - http://dx.doi.org/10.1016/s2542-5196(24)00232-8
VL - 8
ER -