In this section
@article{Monteirinho:2024:10.1038/s41598-024-82840-7,
author = {Monteirinho, Leitao RA and Leitao, R and Wan, IU and Chown, H and Williams, TJ and Fisher, MC and Rhodes, J},
doi = {10.1038/s41598-024-82840-7},
journal = {Scientific Reports},
title = {Detection of fungal sequences in human brain: rDNA locus amplification and deep sequencing},
url = {http://dx.doi.org/10.1038/s41598-024-82840-7},
volume = {14},
year = {2024}
}
TY - JOUR
AB - The aetiology of Alzheimer’s disease (AD) and Parkinson’s disease (PD) are unknown and tend to manifest at a late stage in life; even though these neurodegenerative diseases are caused by different affected proteins, they are both characterized by neuroinflammation. Links between bacterial and viral infection and AD/PD has been suggested in several studies, however, few have attempted to establish a link between fungal infection and AD/PD. In this study we adopted a nanopore-based sequencing approach to characterise the presence or absence of fungal genera in both human brain tissue and cerebrospinal fluid (CSF). We observed the presence of small fungal burden DNA in two AD brains and a control case (extensive amyloid angiopathy). This approach would be well-placed to investigate potential links between microbial infection and neurodegenerative disease.
AU - Monteirinho,Leitao RA
AU - Leitao,R
AU - Wan,IU
AU - Chown,H
AU - Williams,TJ
AU - Fisher,MC
AU - Rhodes,J
DO - 10.1038/s41598-024-82840-7
PY - 2024///
SN - 2045-2322
TI - Detection of fungal sequences in human brain: rDNA locus amplification and deep sequencing
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-024-82840-7
UR - https://www.nature.com/articles/s41598-024-82840-7
VL - 14
ER -
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