BibTex format
@article{Agbevo:2024:10.1186/s12936-024-05199-0,
author = {Agbevo, A and Syme, T and Fagbohoun, J and Fongnikin, A and Ahoga, J and Accrombessi, M and Protopopoff, N and Cook, J and Churcher, TS and Padonou, GG and Sovi, A and Ahogni, I and Govoetchan, R and Todjinou, D and Akogbeto, M and Ngufor, C},
doi = {10.1186/s12936-024-05199-0},
journal = {Malaria Journal},
title = {The experimental hut efficacy of next-generation insecticide-treated nets against pyrethroid-resistant malaria vectors after 12, 24 and 36 months of household use in Benin},
url = {http://dx.doi.org/10.1186/s12936-024-05199-0},
volume = {23},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundCluster-randomized controlled trials (cluster-RCTs) have demonstrated variation in the epidemiological efficacy of different next-generation insecticide-treated net (ITN) types, with some providing shorter-lived impact than others. Further studies are needed to assess changes in the insecticidal durability of these ITNs over time to complement cluster-RCT results.MethodsA series of experimental hut trials were performed to evaluate the bioefficacy of new and field-aged next-generation ITNs (PermaNet® 3.0, Royal Guard®, Interceptor® G2) compared to a pyrethroid-only net (Interceptor®) against pyrethroid-resistant malaria vectors in Covè, southern Benin. Field-aged nets were withdrawn from households at 12, 24 and 36 months. Net pieces cut from whole ITNs were analysed for chemical content, and susceptibility bioassays were performed during each trial to assess changes in insecticide resistance in the Covè vector population.ResultsInterceptor® G2 induced superior mosquito mortality than the other ITNs across all time points. The improved mortality with Interceptor® G2 compared to Interceptor® was evident across all time points but was greater with new nets (odds ratio (OR) = 8.6, 95% CI [7.4, 10.1]) than field-aged nets (OR = 2.5, 95% CI [1.8, 3.5] at 12 months, OR = 2.4, 95% CI [1.6, 3.7] at 24 months and OR = 2.9, 95% CI [1.6, 5.1] at 36 months). New Royal Guard® reduced mosquito fertility compared to the other ITNs, but this improvement fell after field-ageing, particularly at 24 months when it was similar to Interceptor® (11% vs 3%, p = 0.08). When new, mortality was significantly higher with PermaNet® 3.0 compared to Interceptor® (OR = 3.6, 95% CI [3.0, 4.2]); however, this benefit was lost with field-aged nets at 12 months (OR = 1.1, 95% CI [0.8, 1.5]) and 24 months (OR = 0.6, 95% CI [
AU - Agbevo,A
AU - Syme,T
AU - Fagbohoun,J
AU - Fongnikin,A
AU - Ahoga,J
AU - Accrombessi,M
AU - Protopopoff,N
AU - Cook,J
AU - Churcher,TS
AU - Padonou,GG
AU - Sovi,A
AU - Ahogni,I
AU - Govoetchan,R
AU - Todjinou,D
AU - Akogbeto,M
AU - Ngufor,C
DO - 10.1186/s12936-024-05199-0
PY - 2024///
SN - 1475-2875
TI - The experimental hut efficacy of next-generation insecticide-treated nets against pyrethroid-resistant malaria vectors after 12, 24 and 36 months of household use in Benin
T2 - Malaria Journal
UR - http://dx.doi.org/10.1186/s12936-024-05199-0
UR - https://malariajournal.biomedcentral.com/articles/10.1186/s12936-024-05199-0
VL - 23
ER -