In this section
@article{Trotter:2003:10.1016/s0264-410x(02)00630-8,
author = {Trotter, C and Borrow, R and Andrews, N and Miller, E},
doi = {10.1016/s0264-410x(02)00630-8},
journal = {Vaccine},
pages = {1094--1098},
title = {Seroprevalence of meningococcal serogroup C bactericidal antibody in England and Wales in the pre-vaccination era.},
url = {http://dx.doi.org/10.1016/s0264-410x(02)00630-8},
volume = {21},
year = {2003}
}
TY - JOUR
AB - Sera from an age-stratified sample of 1689 individuals, submitted to the PHLS Seroepidemiology Unit between 1996 and 1999 were tested for serum bactericidal antibodies to serogroup C meningococci. Titres decreased during infancy, presumably as maternal antibody waned, and increased in older teenagers, the peak age of meningococcal carriage. The prevalence of antibody titres greater than or equal to 8 was highest in adults, with an average of 25% of adults 25 years old or above with titres above this putative protective level. In the absence of vaccination, antibody may be generated from periods of carriage of serogroup C meningococci, from other meningococcal strains sharing non-capsular antigens, and other cross-reactive organisms. The inverse relationship between disease incidence and the prevalence of 'protective' antibody titres as described by Goldschneider et al. appears more consistent with a titre of > or =8 rather than > or =128, although the proportions 'protected' are much lower here than in Goldschneider's study. This study provides baseline antibody levels which will facilitate the evaluation of the meningococcal serogroup C conjugate vaccination programme.
AU - Trotter,C
AU - Borrow,R
AU - Andrews,N
AU - Miller,E
DO - 10.1016/s0264-410x(02)00630-8
EP - 1098
PY - 2003///
SN - 0264-410X
SP - 1094
TI - Seroprevalence of meningococcal serogroup C bactericidal antibody in England and Wales in the pre-vaccination era.
T2 - Vaccine
UR - http://dx.doi.org/10.1016/s0264-410x(02)00630-8
UR - https://www.ncbi.nlm.nih.gov/pubmed/12559785
VL - 21
ER -
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