BibTex format
@article{Jombart:2025:10.1136/bmjgh-2024-015822,
author = {Jombart, T and Zeng, W and Yao, M and Cori, A and Ahuka-Mundeke, S and Samaha, H and Wilkinson, T and Mossoko, M and Lokonga, J-P and Baabo, D and El, Kadiri El Yamini F and Hoang-Vu, Eozenou P and Yuma, S and Mobula, L},
doi = {10.1136/bmjgh-2024-015822},
journal = {BMJ Global Health},
title = {Contrasting the impact and cost-effectiveness of successive intervention strategies in response to Ebola in the Democratic Republic of the Congo, 2018-2020},
url = {http://dx.doi.org/10.1136/bmjgh-2024-015822},
volume = {10},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Introduction The 10th outbreak of Ebola Virus Disease (EVD) in the Democratic Republic of the Congo (DRC) in 2018–2020 was the largest in DRC’s history and the second largest worldwide. Different strategic response plans (SRPs) were implemented, and the outbreak was eventually stopped after a large scale-up of operations with the SRP 4, which benefited from all public health measures deployed during SRPs 1-3, upon which it developed a more holistic approach including community engagement, logistics and security.Methods We used modelling to characterise EVD transmission and assess the epidemiological impact of the two main response strategies (SRPs 1–3 vs SRP 4). We simulated potential future epidemics with different intervention scenarios, combined with a costing model to evaluate the incremental cost-effectiveness of different strategies.Results We estimated a mean effective reproduction number R of 1.19 (credible interval (95% CrI) = (1.13 ; 1.25)). The spatial spread was moderate with an average 4.4% (95% CrI = (3.5%; 5.4%)) of transmissions moving to different health zones. The scale-up of operations in SRP 4 coincided with a threefold reduction in transmission, and 30% faster control of EVD waves. In simulations, SRP 4 appears cost-saving, although most simulated outbreaks remain small even with SRPs 1–3.Conclusion Most EVD outbreaks are expected to be small and can be contained with SRPs 1–3. In outbreaks with increased transmissibility or in the presence of insecurity, rapid scale-up to SRP 4 is likely to save lives and be cost-effective.
AU - Jombart,T
AU - Zeng,W
AU - Yao,M
AU - Cori,A
AU - Ahuka-Mundeke,S
AU - Samaha,H
AU - Wilkinson,T
AU - Mossoko,M
AU - Lokonga,J-P
AU - Baabo,D
AU - El,Kadiri El Yamini F
AU - Hoang-Vu,Eozenou P
AU - Yuma,S
AU - Mobula,L
DO - 10.1136/bmjgh-2024-015822
PY - 2025///
SN - 2059-7908
TI - Contrasting the impact and cost-effectiveness of successive intervention strategies in response to Ebola in the Democratic Republic of the Congo, 2018-2020
T2 - BMJ Global Health
UR - http://dx.doi.org/10.1136/bmjgh-2024-015822
VL - 10
ER -