In this section
@article{Ferguson:1999,
author = {Ferguson, NM and deWolf, F and Ghani, AC and Fraser, C and Donnelly, CA and Reiss, P and Lange, JM and Danner, SA and Garnett, GP and Goudsmit, J and Anderson, RM},
journal = {Proc Natl Acad Sci U S A},
pages = {15167--15172},
title = {Antigen-driven CD4+ T cell and HIV-1 dynamics: residual viral replication under highly active antiretroviral therapy},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10611356},
volume = {96},
year = {1999}
}
TY - JOUR
AB - Antigen-induced stimulation of the immune system can generate heterogeneity in CD4+ T cell division rates capable of explaining the temporal patterns seen in the decay of HIV-1 plasma RNA levels during highly active antiretroviral therapy. Posttreatment increases in peripheral CD4+ T cell counts are consistent with a mathematical model in which host cell redistribution between lymph nodes and peripheral blood is a function of viral burden. Model fits to patient data suggest that, although therapy reduces HIV replication below replacement levels, substantial residual replication continues. This residual replication has important consequences for long-term therapy and the evolution of drug resistance and represents a challenge for future treatment strategies.
AU - Ferguson,NM
AU - deWolf,F
AU - Ghani,AC
AU - Fraser,C
AU - Donnelly,CA
AU - Reiss,P
AU - Lange,JM
AU - Danner,SA
AU - Garnett,GP
AU - Goudsmit,J
AU - Anderson,RM
EP - 15172
PY - 1999///
SN - 0027-8424
SP - 15167
TI - Antigen-driven CD4+ T cell and HIV-1 dynamics: residual viral replication under highly active antiretroviral therapy
T2 - Proc Natl Acad Sci U S A
UR - http://www.ncbi.nlm.nih.gov/pubmed/10611356
VL - 96
ER -
For any enquiries related to the MRC Centre please contact:
Scientific Manager
Susannah Fisher
mrc.gida@imperial.ac.uk
External Relationships and Communications Manager
Dr Sabine van Elsland
s.van-elsland@imperial.ac.uk