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• Journal article
  Aiello M, Monti S, Inglese M, Forte E, Cavaliere C, Catalano OA, Nicolai E, Salvatore Met al., 2015,

  A multi-modal fusion scheme for the enhancement of PET/MR viewing.

  , EJNMMI Phys, Vol: 2, ISSN: 2197-7364
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• Journal article
  Reynolds HM, Williams S, Zhang A, Chakravorty R, Rawlinson D, Ong CS, Esteva M, Mitchell C, Parameswaran B, Finnegan M, Liney G, Haworth Aet al., 2015,

  Development of a registration framework to validate MRI with histology for prostate focal therapy

  , Medical Physics, Vol: 42, Pages: 7078-7089, ISSN: 0094-2405

  <jats:sec><jats:title>Purpose:</jats:title><jats:p>Focal therapy has been proposed as an alternative method to whole‐gland treatment for prostate cancer when aiming to reduce treatment side effects. The authors recently validated a radiobiological model which takes into account tumor location and tumor characteristics including tumor cell density, Gleason score, and hypoxia in order to plan optimal dose distributions for focal therapy. The authors propose that this model can be informed using multiparametric MRI (mpMRI) and in this study present a registration framework developed to map prostate mpMRI and histology data, where histology will provide the “ground truth” data regarding tumor location and biology. The authors aim to apply this framework to a growing database to develop a prostate biological atlas which will enable MRI based planning for prostate focal therapy treatment.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Six patients scheduled for routine radical prostatectomy were used in this proof‐of‐concept study. Each patient underwent mpMRI scanning prior to surgery, after which the excised prostate specimen was formalin fixed and mounted in agarose gel in a custom designed sectioning box. T2‐weighted MRI of the specimen in the sectioning box was acquired, after which 5 mm sections of the prostate were cut and histology sections were microtomed. A number of image processing and registration steps were used to register histology images with <jats:italic>ex vivo</jats:italic> MRI and deformable image registration (DIR) was applied to 3D T2w images to align the <jats:italic>in vivo</jats:italic> and <jats:italic>ex vivo</jats:italic> MRI data. Dice coefficient metrics and corresponding feature points from two independent annotators were selected in order to assess the DIR accuracy.</jats:p></jats:sec><jats:sec&g

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• Journal article
  Grech-Sollars M, Vaqas B, Thompson G, Honeyfield L, O'Neil K, Waldman ADet al., 2015,

  NIMG-30an MRS and PET guided biopsy tool for ultrasound-based intra-operative neuro-navigational systems

  , Neuro-Oncology, Vol: 17, Pages: v160.2-v160, ISSN: 1522-8517
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• Journal article
  Abraham CL, Bangerter NK, McGavin LS, Peters CL, Drew AJ, Hanrahan CJ, Anderson AEet al., 2015,

  Accuracy of 3D dual echo steady state (DESS) MR arthrography to quantify acetabular cartilage thickness

  , Journal of Magnetic Resonance Imaging, Vol: 42, Pages: 1329-1338, ISSN: 1053-1807

  <jats:sec><jats:title>Purpose</jats:title><jats:p>To deploy and quantify the accuracy of 3D dual echo steady state (DESS) MR arthrography with hip traction to image acetabular cartilage. Clinical magnetic resonance imaging (MRI) sequences used to image hip cartilage often have reduced out‐of‐plane resolution and may lack adequate signal‐to‐noise to image cartilage.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>Saline was injected into four cadaver hips placed under traction. 3D DESS MRI scans were obtained before and after cores of cartilage were harvested from the acetabulum; the two MRIs were spatially aligned to reference core positions. The thickness of cartilage cores was measured under microscopy to serve as the reference standard. 3D reconstructions of cartilage and subchondral bone were generated using automatic and semiautomatic image segmentation. Cartilage thickness estimated from the 3D reconstructions was compared to physical measurements using Bland–Altman plots.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>As revealed by the automatic segmentation mask, saline imbibed the joint space throughout the articulating surface, with the exception of the posteroinferior region in two hips. Locations where air bubbles were introduced and regions of suspected low density bone disrupted an otherwise smooth automatic segmentation mask. Automatic and semiautomatic segmentation yielded a bias ± repeatability coefficient (95% limits of agreement) of 0.10 ± 0.51 mm (−0.41 to 0.61 mm) and 0.06 ± 0.43 mm (−0.37 to 0.49 mm), respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Cartilage thickness can be estimated to within ∼0.5 mm of the physical value with 95% conf

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• Conference paper
  Ordidge K, Grech-Sollars M, Honeyfield L, Khan S, O'Neill K, Peterson D, Vaqas B, Roncaroli F, Towey D, Barwick T, Waldman Aet al., 2015,

  18F-FLUOROMETHYLCHOLINE (18F-FMC) PET/CT AND MAGNETIC RESONANCE SPECTROSCOPY (MRS) IMAGING AND TISSUE BIOMARKERS OF CELL MEMBRANE TURNOVER IN PRIMARY BRAIN GLIOMAS-A PILOT STUDY

  , Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, Pages: 5-5, ISSN: 1522-8517
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  • Citations: 1
• Journal article
  Wang H, Bangerter NK, Park DJ, Adluru G, Kholmovski EG, Xu J, DiBella Eet al., 2015,

  Comparison of centric and reverse‐centric trajectories for highly accelerated three‐dimensional saturation recovery cardiac perfusion imaging

  , Magnetic Resonance in Medicine, Vol: 74, Pages: 1070-1076, ISSN: 0740-3194

  <jats:sec><jats:title>Purpose</jats:title><jats:p>Highly undersampled three‐dimensional (3D) saturation‐recovery sequences are affected by k‐space trajectory since the magnetization does not reach steady state during the acquisition and the slab excitation profile yields different flip angles in different slices. This study compares centric and reverse‐centric 3D cardiac perfusion imaging.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>An undersampled (98 phase encodes) 3D ECG‐gated saturation‐recovery sequence that alternates centric and reverse‐centric acquisitions each time frame was used to image phantoms and in vivo subjects. Flip angle variation across the slices was measured, and contrast with each trajectory was analyzed via Bloch simulation.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Significant variations in flip angle were observed across slices, leading to larger signal variation across slices for the centric acquisition. In simulation, severe transient artifacts were observed when using the centric trajectory with higher flip angles, placing practical limits on the maximum flip angle used. The reverse‐centric trajectory provided less contrast, but was more robust to flip angle variations.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Both of the k‐space trajectories can provide reasonable image quality. The centric trajectory can have higher CNR, but is more sensitive to flip angle variation. The reverse‐centric trajectory is more robust to flip angle variation. Magn Reson Med 74:1070–1076, 2015. © 2014 Wiley Periodicals, Inc.</jats:p></jats:sec>

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• Journal article
  Lally P, PAULIAH S, MONTALDO P, CHABAN B, Oliveira V, Bainbridge A, Soe A, Pattnayak S, Clarke P, Satodia P, Harigopal S, Abernethy LJ, Turner MA, Huertas Ceballos A, Shankaran S, THAYYIL Set al., 2015,

  Magnetic Resonance Biomarkers in Neonatal Encephalopathy (MARBLE): A Prospective Multi-Country Study

  , BMJ Open, Vol: 5, ISSN: 2044-6055

  Despite cooling adverse outcomes are seen in upto half of the surviving infants after neonatal encephalopathy. A number of novel adjunct drug therapies with cooling have been shown to be highly neuroprotective in animal studies, and are currently awaiting clinical translation. Riggorous evaluation of these therapies in phase II trials using surrogate magnetic resonance biomarkers may speed up thier bench to bedside translation. A recent systematic review of single centres studies have suggested that Magnetic resonance spectroscopy biomarkers offers the best promise, however the prognostic accuracy of these biomarkers in cooled encephalopathic babies in a multicentre setting using different MR scan makes is not known.

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• Journal article
  Ibrahim T, Few K, Greenwood R, Smith C, Malcolm P, Johnson G, Lally P, Thayyil S, Clarke Pet al., 2015,

  'Feed and wrap' or sedate and immobilise for neonatal brain MRI?

  , ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, Vol: 100, Pages: F465-U95, ISSN: 1359-2998
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  • Citations: 14
• Journal article
  Soo A, Taha S, Lally P, Kirmi O, Jones B, Thayyil Set al., 2015,

  Assessment of optic nerve development using post-mortem Magnetic Resonance Imaging (MRI) in fetuses and newborns

  , Prenatal Diagnosis, Vol: 35, Pages: 1262-1264, ISSN: 0197-3851

  What's already known about this topic?Biometric studies of fetal orbit and lens development have been shown to correlate with gestational age.No available data on optic nerve measurements in fetuses/neonates.What does this study add?Normal fetal/neonatal optic nerve diameter measurements for gestational age as measured on post‐mortem MRI scans.

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• Journal article
  Arthurs OJ, Thayyil S, Pauliah SS, Jacques TS, Chong WK, Gunny R, Saunders D, Addison S, Lally P, Cady E, Jones R, Norman W, Scott R, Robertson NJ, Wade A, Chitty L, Taylor AM, Sebire NJet al., 2015,

  Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children

  , CLINICAL RADIOLOGY, Vol: 70, Pages: 872-880, ISSN: 0009-9260
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  • Citations: 73

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