Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    Pauliah S, Lally P, Price D, Bainbridge A, Kurien J, Sivaswami N, Cowan F, Balraj G, Swamy R, Madhavan V, Nair M, Krishnakumar P, Cady E, Shankaran S, Thayyil Set al., 2014,

    PC.106 Cerebral Injury and Early Childhood Neurodevelopmental Outcome following Neonatal Encephalopathy in a Middle-income Country.

    , Arch Dis Child Fetal Neonatal Ed, Vol: 99 Suppl 1, Pages: A72-A73

    Although neonatal encephalopathy (NE), accounts for 1 million neonatal deaths annually in low-and middle-income countries (LMIC), underlying brain injury and long term outcomes are not well characterised in LMIC.

  • Journal article
    Lally P, Zhang H, Pauliah S, Price D, Bainbridge A, Balraj G, Cady E, Shankaran S, Thayyil Set al., 2014,

    8.9 Microstructural Changes in Neonatal Encephalopathy Revealed with the Neurite Orientation Dispersion and Density Imaging (NODDI) Model.

    , Arch Dis Child Fetal Neonatal Ed, Vol: 99 Suppl 1

    Although diffusion tensor imaging (DTI) fractional anisotropy (FA) is commonly used to quantify neural injury, it is non-specific and affected by a number of microstructural changes.

  • Journal article
    Kaggie JD, Hadley JR, Badal J, Campbell JR, Park DJ, Parker DL, Morrell G, Newbould RD, Wood AF, Bangerter NKet al., 2014,

    A 3 T Sodium and Proton Composite Array Breast Coil

    , MAGNETIC RESONANCE IN MEDICINE, Vol: 71, Pages: 2231-2242, ISSN: 0740-3194
  • Journal article
    Newbould RD, Nicholas R, Thomas CL, Quest R, Lee JSZ, Honeyfield L, Colasanti A, Malik O, Mattoscio M, Matthews PM, Sormani MP, Waldman AD, Muraroc PAet al., 2014,

    Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis

    , NeuroImage: Clinical, Vol: 4, Pages: 641-648, ISSN: 2213-1582

    BackgroundMultiple sclerosis (MS) is a heterogeneous disorder with a progressive course that is difficult to predict on a case-by-case basis. Natural history studies of MS have demonstrated that age influences clinical progression independent of disease duration.ObjectiveTo determine whether age would be associated with greater CNS injury as detected by magnetization transfer MRI.Materials and methodsForty MS patients were recruited from out-patient clinics into two groups stratified by age but with similar clinical disease duration as well as thirteen controls age-matched to the older MS group. Images were segmented by automated programs and blinded readers into normal appearing white matter (NAWM), normal appearing gray matter (NAGM), and white matter lesions (WMLs) and gray matter lesions (GMLs) in the MS groups. WML and GML were delineated on T2-weighted 3D fluid-attenuated inversion recovery (FLAIR) and T1 weighted MRI volumes. Mean magnetization transfer ratio (MTR), region volume, as well as MTR histogram skew and kurtosis were calculated for each region.ResultsAll MTR measures in NAGM and MTR histogram metrics in NAWM differed between MS subjects and controls, as expected and previously reported by several studies, but not between MS groups. However, MTR measures in the WML did significantly differ between the MS groups, in spite of no significant differences in lesion counts and volumes.ConclusionsDespite matching for clinical disease duration and recording no significant WML volume difference, we demonstrated strong MTR differences in WMLs between younger and older MS patients. These data suggest that aging-related processes modify the tissue response to inflammatory injury and its clinical outcome correlates in MS.

  • Journal article
    Grech-Sollars M, Saunders DE, Phipps KP, Kaur R, Paine SML, Jacques TS, Clayden JD, Clark CAet al., 2014,

    Challenges for the functional diffusion map in pediatric brain tumors

    , NEURO-ONCOLOGY, Vol: 16, Pages: 449-456, ISSN: 1522-8517
  • Journal article
    Lally PJ, Price DL, Pauliah SS, Bainbridge A, Kurien J, Sivasamy N, Cowan FM, Balraj G, Ayer M, Satheesan K, Ceebi S, Wade A, Swamy R, Padinjattel S, Hutchon B, Vijayakumar M, Nair M, Padinharath K, Zhang H, Cady EB, Shankaran S, Thayyil Set al., 2014,

    Neonatal encephalopathic cerebral injury in south india assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome

    , PLOS One, Vol: 9, ISSN: 1932-6203

    Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early childhood outcomes in South India.MethodsWe recruited consecutive term or near term infants with evidence of perinatal asphyxia and a Thompson encephalopathy score ≥6 within 6 h of birth, over 6 months. We performed conventional MR imaging, diffusion tensor MR imaging and thalamic proton MR spectroscopy within 3 weeks of birth. We computed group-wise differences in white matter fractional anisotropy (FA) using tract based spatial statistics. We allocated Sarnat encephalopathy stage aged 3 days, and evaluated neurodevelopmental outcomes aged 3½ years using Bayley III.ResultsOf the 54 neonates recruited, Sarnat staging was mild in 30 (56%); moderate in 15 (28%) and severe in 6 (11%), with no encephalopathy in 3 (6%). Six infants died. Of the 48 survivors, 44 had images available for analysis. In these infants, imaging indicated perinatal rather than established antenatal origins to injury. Abnormalities were frequently observed in white matter (n = 40, 91%) and cortex (n = 31, 70%) while only 12 (27%) had abnormal basal ganglia/thalami. Reduced white matter FA was associated with Sarnat stage, deep grey nuclear injury, and MR spectroscopy N-acetylaspartate/choline, but not early Thompson scores. Outcome data were obtained in 44 infants (81%) with 38 (79%) survivors examined aged 3½ years; of these, 16 (42%) had adverse neurodevelopmental outcomes.ConclusionsNo infants had evidence for established brain lesions, suggesting potentially treatable perinatal origins. White matter injury was more common than deep brain nuclei injury. Our results support the need for rigorous evaluation of the efficacy of rescue

  • Conference paper
    Wang H, Bangerter N, Kholmovski EG, DiBella Eet al., 2014,

    Dark rim artifacts from motion in highly accelerated 3D cardiac perfusion imaging

    , ISMRM 22nd Annual Meeting
  • Conference paper
    Kaggie JD, Sapkota N, Jeong K, Shi X, Morrell GR, Bangerter N, Jeong E-Ket al., 2014,

    Synchronous 1 H and 23 Na dual-nuclear MRI on a clinical MRI system, equipped with a time-shared second transmit channel

    , ISMRM 22nd Annual Meeting
  • Conference paper
    Kogan F, Rosenberg J, McWalter EJ, Park D, Matzat S, Perkins K, Tran C, Taylor M, Sveinsson B, Newbould R, Monu U, Wang H, Bangerter N, Gold GEet al., 2014,

    Quantitative MRI of Osteoarthritis for Multicenter Trials: Standardization between Different Centers and Manufacturers

    , ISMRM 22nd Annual Meeting
  • Conference paper
    Mendoza MA, Villalpando R, Park DJ, Gardner D, Perkins K, Bangerter NKet al., 2014,

    Water Fat Separation with Multiple-Acquisition bSSFP

    , ISMRM 22nd Annual Meeting

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://www.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=1107&limit=10&resgrpMemberPubs=true&resgrpMemberPubs=true&page=64&respub-action=search.html Current Millis: 1778579842809 Current Time: Tue May 12 10:57:22 BST 2026

Contact


For enquiries about the MRI Physics Collective, please contact:

Mary Finnegan
Senior MR Physicist at the Imperial College Healthcare NHS Trust

Pete Lally
Assistant Professor in Magnetic Resonance (MR) Physics at Imperial College

Jan Sedlacik
MR Physicist at the Robert Steiner MR Unit, Hammersmith Hospital Campus