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  • Conference paper
    Yang G, Hipwell J, Tanner C, Hawkes D, Arridge Set al., 2012,

    Joint registration and limited-angle reconstruction of digital breast tomosynthesis

    , 11th International Workshop on Breast Imaging, IWDM 2012, Publisher: Springer, Pages: 713-720, ISSN: 0302-9743

    Digital breast tomosynthesis (DBT), an emerging imaging modality, provides a pseudo-3D image of the breast. Algorithms to aid the human observer process these large datasets involve two key tasks: reconstruction and registration. Previous studies separated these steps, solving each task independently. This can be effective if reconstructing using a complete set of data, e.g., in cone beam CT, assuming that only simple deformations exist. However, for ill-posed limited-angle problems such as DBT, estimating the deformation is complicated by the significant artefacts associated with DBT reconstructions, leading to severe inaccuracies in the registration. In this paper, we present an innovative algorithm, which combines reconstruction of a pair of temporal DBT acquisitions with their simultaneous registration. Using various computational phantoms and in vivo DBT simulations, we show that, compared to the conventional sequential method, jointly estimating image intensities and transformation parameters gives superior results with respect to reconstruction fidelity and registration accuracy.

  • Journal article
    Ferreira PF, Gatehouse PD, Firmin DN, 2012,

    Myocardial first-pass perfusion imaging with hybrid-EPI: frequency-offsets and potential artefacts

    , Journal of Cardiovascular Magnetic Resonance, Vol: 14, Pages: 44-44, ISSN: 1097-6647

    BackgroundFirst-pass myocardial perfusion is often imaged with a tailored hybrid centric interleaved echo-planar-imaging sequence, providing rapid image acquisition with good contrast enhancement. The centric interleaved phase-encode order minimises the effective time-of-echo but it is sensitive to frequency-offsets. This short article aims to show possible artefacts that might originate with this sequence, in the context of first-pass perfusion imaging, when frequency-offsets are present. Non-uniform magnitude modulation effects were also analysed.MethodsNumerical and phantom simulations were used to illustrate the effects of frequency-offsets and non-uniform magnitude modulation with this sequence in a typical perfusion protocol. In vivo data was post-processed to analyse the h-EPI’s sensitivity to the frequency-offsets.ResultsThe centric phase-order was shown to be highly sensitive to frequency-offsets due to its symmetrical phase slope. Resulting artefacts include blurring, and splitting of the image into two identical copies along the phase-encode direction. It was also shown that frequency-offsets can introduce signal loss and ghosting of the right ventricle signal into the myocardium. The in vivo results were confirmed by numerical and phantom simulations. Magnitude modulation effects were found to be small.ConclusionsImaging first-pass myocardial perfusion with an hybrid centric echo-planar-imaging sequence can be corrupted with ghosting and splitting of the image due to frequency-offsets.

  • Poster
    Malcolme-Lawes L, Juli C, Karim R, Bai W, Quest R, Lim PB, Jamil-Copley S, Kojodjojo P, Ariff B, Davies DW, Rueckert D, Hunter R, Boubertakh R, Petersen S, Schilling R, Kanagaratnam P, Peters NSet al., 2012,

    AUTOMATED ANALYSIS OF ATRIAL DELAYED ENHANCEMENT CARDIAC MRI CORRELATES WITH VOLTAGE, AF RECURRENCE POST-ABLATION, AND HIGH STROKE RISK

    , Annual Conference of the British-Cardiovascular-Society (BCS)
  • Journal article
    Quist B, Hargreaves BA, Cukur T, Morrell GR, Gold GE, Bangerter NKet al., 2012,

    Simultaneous fat suppression and band reduction with large‐angle multiple‐acquisition balanced steady‐state free precession

    , Magnetic Resonance in Medicine, Vol: 67, Pages: 1004-1012, ISSN: 0740-3194

    <jats:title>Abstract</jats:title><jats:p>Balanced steady‐state free precession (bSSFP) MRI is a rapid and signal‐to‐noise ratio‐efficient imaging method, but suffers from characteristic bands of signal loss in regions of large field inhomogeneity. Several methods have been developed to reduce the severity of these banding artifacts, typically involving the acquisition of multiple bSSFP datasets (and the accompanying increase in scan time). Fat suppression with bSSFP is also challenging; most existing methods require an additional increase in scan time, and some are incompatible with bSSFP band‐reduction techniques. This work was motivated by the need for both robust fat suppression and band reduction in the presence of field inhomogeneity when using bSSFP for flow‐independent peripheral angiography. The large flip angles used in this application to improve vessel conspicuity and contrast lead to specific absorption rate considerations, longer repetition times, and increased severity of banding artifacts. In this work, a novel method that simultaneously suppresses fat and reduces bSSFP banding artifact with the acquisition of only two phase‐cycled bSSFP datasets is presented. A weighted sum of the two bSSFP acquisitions is taken on a voxel‐by‐voxel basis, effectively synthesizing an off‐resonance profile at each voxel that puts fat in the stop band while keeping water in the pass band. The technique exploits the near‐sinusoidal shape of the bSSFP off‐resonance spectrum for many tissues at large (&gt;50°) flip angles. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc.</jats:p>

  • Conference paper
    Park DJ, Javed A, Bangerter N, Kaggie JD, Morrell Get al., 2012,

    Practical SAR Constraints of the Bloch-Siegert B1 Mapping Method at 3T

    , ISMRM 20th Annual Meeting
  • Conference paper
    Kaggie JD, Campbell JR, Badal J, Hadley R, Park DJ, Morrell G, Parker D, Newbould RD, Bangerter Net al., 2012,

    A Sodium Phased Array Breast Coil with Hydrogen Transceive

    , ISMRM 20th Annual Meeting
  • Journal article
    Ismail TF, Hewins B, Jabbour A, Mistry N, Ferreira PF, Gulati A, Wage R, Clarysse P, Croisille P, Pennell DJ, Prasad SKet al., 2012,

    The relationship between interstitial fibrosis and contractile function in HCM: a combined T1-mapping and CSPAMM tagging study

    , Journal of Cardiovascular Magnetic Resonance, Vol: 14, ISSN: 1097-6647
  • Conference paper
    Wang H, Bangerter N, Adluru G, Schabel M, Morrell GR, DiBella EVRet al., 2012,

    Comparison of highly accelerated TV and low rank methods for breast DCE data

    , ISMRM 20th Annual Meeting
  • Journal article
    Jabbour A, Ismail TF, De Noronha SV, Shakespeare C, Zaman S, Sotubo O, Zaman SS, Ettles C, Hewins B, Wage R, Gulati A, Ferreira PF, Croisille P, Feng Y, Norita K, Mohiaddin RH, He T, Pepper J, Firmin DN, Sheppard M, Pennell DJ, Petrou M, Prasad SKet al., 2012,

    Non-invasive assessment of interstitial myocardial fibrosis in pressure-overload left ventricular hypertrophy

    , Journal of Cardiovascular Magnetic Resonance, Vol: 14, ISSN: 1097-6647
  • Journal article
    Gallagher JJ, Finnegan ME, Grehan B, Dobson J, Collingwood JF, Lynch MAet al., 2012,

    Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress

    , Journal of Alzheimer's Disease, Vol: 28, Pages: 147-161, ISSN: 1387-2877

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