BibTex format
@article{Lally:2014:10.1136/archdischild-2014-306576.146,
author = {Lally, P and Pauliah, S and Price, D and Bainbridge, A and Addison, S and Soe, A and Pattnayak, S and Satodia, P and Wayte, S and Ng'andwe, E and Clarke, P and Johnson, G and Harigopal, S and English, P and Abernethy, LJ and Turner, M and Cheong, J and Shankaran, S and Cady, E and Thayyil, S},
doi = {10.1136/archdischild-2014-306576.146},
journal = {Arch Dis Child Fetal Neonatal Ed},
title = {PC.45Quantification of N-Acetylaspartate Concentration in the Neonatal Brain: Initial Results from the Multi-Centre Marble Study.},
url = {http://dx.doi.org/10.1136/archdischild-2014-306576.146},
volume = {99 Suppl 1},
year = {2014}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Early cerebral proton magnetic resonance spectroscopy (MRS) predicts medium-term outcomes in neonatal encephalopathy (NE). Metabolite peak-area ratios are most commonly used for prognosis, but conflate pathological information from different metabolites. N-acetylaspartate (NAA) is predominantly neuronal and neuronal loss should result in reduced NAA absolute-concentration ([NAA]). Thus, thalamic [NAA] should offer significant prognostic value but is difficult to measure in a clinical setting. We have established a protocol for multi-centre [NAA] measurement with the aim to use it as a surrogate biomarker in phase II clinical trials.
AU - Lally,P
AU - Pauliah,S
AU - Price,D
AU - Bainbridge,A
AU - Addison,S
AU - Soe,A
AU - Pattnayak,S
AU - Satodia,P
AU - Wayte,S
AU - Ng'andwe,E
AU - Clarke,P
AU - Johnson,G
AU - Harigopal,S
AU - English,P
AU - Abernethy,LJ
AU - Turner,M
AU - Cheong,J
AU - Shankaran,S
AU - Cady,E
AU - Thayyil,S
DO - 10.1136/archdischild-2014-306576.146
PY - 2014///
TI - PC.45Quantification of N-Acetylaspartate Concentration in the Neonatal Brain: Initial Results from the Multi-Centre Marble Study.
T2 - Arch Dis Child Fetal Neonatal Ed
UR - http://dx.doi.org/10.1136/archdischild-2014-306576.146
UR - http://www.ncbi.nlm.nih.gov/pubmed/25021271
VL - 99 Suppl 1
ER -