Past research projects
The impact of inter-hospital transportation: Neonatal outcomes and implications for
families - REC reference: 17/LO/1822
The study is led by Dr Don Sharkey, Faculty of Medicine and Health Sciences, School of Medicine, Division of Child Health,
Queen’s Medical Centre, Nottingham.
The study will use population level data held within the NNRD to examine the patterns of transfers in the UK in recent years and the potential impact this has on families in terms of the time away from their booking hospital. The study will also look at a defined group of babies, those with hypoxic-ischaemic encephalopathy, to see how delivery of therapeutic hypothermia is evolving in the UK and if there are any changes in short-term outcomes observed with inter-hospital transfer.
Fortified mother’s own and donor human milk on growth and health outcomes at discharge in preterm infants in Scotland: retrospective cohort analysis - REC Reference: 17/NS/0052
This study is led by Mrs Wesam Alyahya, PhD student in Human Nutrition, University of Glasgow and supervised by Prof Christine Edwards, Professor of Nutritional Physiology, at Human Nutrition in the School of Medicine Dentistry and Nursing University of Glasgow.
The aim of the study is to use anonymised data held in the National Neonatal Research Database (NNRD) to measure the association between using fortified donor human milk (DHM) and outcomes such as growth, length of hospital stays and infection in babies born at less than 32 weeks gestation in Scotland.
- Fortified Milk Study cover letter
- Fortified Milk Study Protocol
- Fortified Milk HRA approval
- Fortified Milk REC approval
Comparison of admission rates to neonatal units between pulse oximetry screening and non-pulse oximetry screening Units - REC reference: 17/LO/0332
The pulse oximetry study is led by Dr Andrew Ewer, Professor of Neonatal Medicine, University of Birmingham with Co-investigators: Prof Tracy Roberts, Dr Karen Pickering, Dr Pelham Barton and Dr Christopher Gale.
- Pulse oximetry study invitation letter
- Pulse oximetry protocol
- Pulse oximetry REC Ref 17/LO/0332
- Pulse oximetry Letter of HRA Approval
Inhaled nitric oxide (iNO) - REC reference: 16/WS/0228
The iNO (Inhaled nitric oxide) study’s Chief Investigator is Nimish Subhedar, Neonatologist, Liverpool Women’s Hospital. Dr Chris Gale, Senior Lecturer, Imperial College, London and Eugene Statnikov, Senior Data Manager, Neonatal Data Analysis Unit, Imperial College, London are Co-investigators.
Inhaled nitric oxide (iNO) is widely used in the treatment of hypoxaemic respiratory failure and persistent pulmonary hypertension of the newborn. Although a well-established therapy in term and near-term infants, its use in preterm infants < 34 weeks’ gestation remains controversial. Population based data indicates that there is wide variation in administration rates amongst US hospitals, but there is no equivalent data from the UK or mainland Europe [1-4]. Data from individual centres and multicentre studies suggests that the use of iNO is increasing in recent years, especially in preterm infants, despite the lack of a clear evidence base in this population.
The iNO study aims to describe hospital variation in patient demographics and treatment rates relating to the use of inhaled nitric oxide in term and preterm infants admitted to neonatal units in England.
Estimating incidence of Group B Streptococcus-associated neonatal encephalopathy - REC reference: 17/EE/0018
- Group B Streptococcus invitation letter
- Group B Streptococcus protocol
- Group B Streptococcus REC ref 17/EE/0018
- Group B Streptococcus letter of HRA approval
Acute postnatal transfer and outcomes in extremely preterm babies” research study - REC reference : 16/EM/0351
This study is lead by Chief Investigator: Dr Christopher Gale with Co-investigators: Dr Kjell Helenius and Professor Liisa Lehtonen (Turku University Hospital, Finland) Professor Neena Modi and Statistician: Dr Nicholas Longford. The study aims to determine the impact of acute postnatal transfer (within 48 hours of birth) on mortality and morbidity among extremely preterm infants.
- Acute postnatal transfer invitation letter
- Acute postnatal transfer protocol
- Acute postnatal transfer REC Ref 16/EM/0351
- Acute postnatal transfer Letter of HRA approval
NeoNet – REC Reference: 15/NW/0503
The aim of NeoNet, led by Professor Martin Pitt, Associate Professor of Healthcare Modelling and Simulation, University of Exeter Medical School, is to develop a computer model of demand and capacity for neonatal care in England. The model runs through simulated time and predicts variation in unit workload, periods of overload and unit closure, number and distances of required transfers, and distances from the parent’s home location to the location of care of the infant. Infants are born in the model with varying needs; they may access specialist surgical/cardiac services, intensive care, high dependency care, special care and transitional care. The number, location, type and size of units may be varied and the impact on service providers and parents predicted. This national model builds on a previous regional model developed for the South West Peninsula Region.
- NDAU circulation letter (pdf)
- NeoNet agreement (pdf)
- Neonet Protocol (pdf)
- NeoNet REC Ref 15/NW/0503 (pdf)
The NIHR Final Report for NeoNet "A framework to address key issues of neonatal service configuration in England: the NeoNet multimethods study" can be downloaded here https://www.journalslibrary.nihr.ac.uk/hsdr/hsdr06350/#/abstract
UK Neonatal Collaborative Necrotising Enterocolitis Study: using operational clinical data captured electronically at the point of care for surveillance and research: UKNC - NEC Study - REC ref: 11/LO/1430
Lead: Dr Cheryl Battersby, Imperial College, email@example.com
Background: There is a poor understanding of the epidemiology, multi-factorial aetiology and pathophysiology of NEC. Strategies for prevention remain elusive, making this an issue of prime importance for neonatal care. There are scant population incidence data, most previous studies have reported by birth weight categories rather than gestational age, and case-definitions have been inconsistent. Interventional studies require good baseline data and an objective case-definition.
- To establish an objective case-definition for NEC
- To determine the population incidence of NEC in England
- To identify enteral-feed related factors that precede onset of NEC in order to inform the design of future interventional randomised controlled trials
- UKNC - NEC Protocol
- UKNC - NEC REC Ref: 11/LO/1430
- UKNC - NEC PIS
- UKNC - NEC study poster
- UKNC - NEC FAQ's
Bliss Staffing Study: Neonatal Economic, Staffing and Clinical Outcomes Project (NESCOP)
The DIN Project: Down syndrome In Neonatal units.
- DIN project invitation letter
- DIN project protocol
- DIN information leaflet
- DIN project REC ref: 13/SC/0124
Modelling neonatal care pathways: costs and consequences for the future
Lead: Sarah Seaton, University of Leicester
- Modelling neonatal care pathways: invitation letter
- Modelling neonatal care pathways: information leaflet
- Modelling neonatal care pathways: REC ref: 14/NW/0349
Gentamicin, Genetic Variation and Deafness in Preterm Children (Mitogent)
Leads: Dr Maria Bitner-Glindzicz and Dr Shamima Rahman, UCL Institute of Child Health
British Paediatric Surveillance Unit Neonatal Exchange Blood Transfusion (EBT):
Lead: Dr Ruth Gottstein, Central Manchester University Hospitals NHS Foundation Trust
- Neonatal Exchange Blood Transfusion protocol
- Neonatal Exchange Blood Transfusion (EBT) patient information sheet
- Neonatal Exchange Blood Transfusion (EBT) REC ref: 13/NW/0063
- RCPCH BPSU Findings