@article{Najer:2022:10.1021/acscentsci.1c01368,
author = {Najer, A and Blight, J and Ducker, CB and Gasbarri, M and Brown, JC and Che, J and Hogset, H and Saunders, C and Ojansivu, M and Lu, Z and Lin, Y and Yeow, J and Rifaie, Graham O and Potter, M and Tonkin, R and Penders, J and Doutch, JJ and Georgiadou, A and Barriga, HMG and Holme, MN and Cunnington, AJ and Bugeon, L and Dallman, MJ and Barclay, WS and Stellacci, F and Baum, J and Stevens, MM},
doi = {10.1021/acscentsci.1c01368},
journal = {ACS Central Science},
pages = {1238--1257},
title = {Potent virustatic polymer-lipid nanomimics block viral entry and inhibit malaria parasites in vivo},
url = {http://dx.doi.org/10.1021/acscentsci.1c01368},
volume = {8},
year = {2022}
}

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TY  - JOUR
AB  - Infectious diseases continue to pose a substantial burden on global populations, requiring innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed modular synthetic polymer nanoparticles that mimic functional components of host cell membranes, yielding multivalent nanomimics that act by directly binding to varied pathogens. Nanomimic blood circulation time was prolonged by reformulating polymer–lipid hybrids. Femtomolar concentrations of the polymer nanomimics were sufficient to inhibit herpes simplex virus type 2 (HSV-2) entry into epithelial cells, while higher doses were needed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given their observed virustatic mode of action, the nanomimics were also tested with malaria parasite blood-stage merozoites, which lose their invasive capacity after a few minutes. Efficient inhibition of merozoite invasion of red blood cells was demonstrated both in vitro and in vivo using a preclinical rodent malaria model. We envision these nanomimics forming an adaptable platform for developing pathogen entry inhibitors and as immunomodulators, wherein nanomimic-inhibited pathogens can be secondarily targeted to sites of immune recognition.
AU  - Najer,A
AU  - Blight,J
AU  - Ducker,CB
AU  - Gasbarri,M
AU  - Brown,JC
AU  - Che,J
AU  - Hogset,H
AU  - Saunders,C
AU  - Ojansivu,M
AU  - Lu,Z
AU  - Lin,Y
AU  - Yeow,J
AU  - Rifaie,Graham O
AU  - Potter,M
AU  - Tonkin,R
AU  - Penders,J
AU  - Doutch,JJ
AU  - Georgiadou,A
AU  - Barriga,HMG
AU  - Holme,MN
AU  - Cunnington,AJ
AU  - Bugeon,L
AU  - Dallman,MJ
AU  - Barclay,WS
AU  - Stellacci,F
AU  - Baum,J
AU  - Stevens,MM
DO  - 10.1021/acscentsci.1c01368
EP  - 1257
PY  - 2022///
SN  - 2374-7943
SP  - 1238
TI  - Potent virustatic polymer-lipid nanomimics block viral entry and inhibit malaria parasites in vivo
T2  - ACS Central Science
UR  - http://dx.doi.org/10.1021/acscentsci.1c01368
UR  - http://hdl.handle.net/10044/1/97043
VL  - 8
ER  - 

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