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• Journal article
  MacLeod MA, Knott KD, Allinson JP, Finney LJ, Wiseman DJ, Ritchie AI, Braddy-Green A, Barlett-Pestell S, Lopez R, Sun L, Webb P, Dalal P, Rubens M, Davies S, Haskard DO, Devaraj A, Donaldson GC, Khamis RY, Nicol ED, Wedzicha JAet al., 2025,

  Prevalence and Clinical Correlates of Radiologically Detected Coronary Artery Disease in Chronic Obstructive Pulmonary Disease A Cross-Sectional Observational Study

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 211, Pages: 946-956, ISSN: 1073-449X
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  • Citations: 3
• Journal article
  Chepkirui M, Dellicour S, Musuva R, Odero I, Omondi B, Omondi B, Onyango E, Barsosio H, Otiso L, Okomo G, Waweru M, Lesosky M, Tancred T, Alhassan Y, Kariuki S, Terkuile F, Taegtmeyer Met al., 2025,

  Missed opportunities for digital health data use in healthcare decision-making: A cross-sectional digital health landscape assessment in Homa Bay county, Kenya

  , PLOS DIGITAL HEALTH, Vol: 4
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  • Citations: 1
• Journal article
  Chen J-L, Wang B, Lu Y, Antoun E, Bird O, Drennan PG, Yin Z, Liu G, Yao X, Pidoux M, Bates A, Jayathilaka D, Wang J, Angus B, Beer S, Espinosa A, Baillie JK, Semple MG, Openshaw PJM, Alex B, Andrikopoulos P, Bach B, Barclay WS, Bogaert D, Chand M, Chechi K, Cooke GS, da Silva Filipe A, de Silva T, Docherty AB, dos Santos Correia G, Dumas M-E, Dunning J, Fletcher T, Green CA, Greenhalf W, Griffin JL, Gupta RK, Harrison EM, Ho AYW, Holden K, Horby PW, Ijaz S, Khoo S, Klenerman P, Law A, Lewis MR, Liggi S, Lim WS, Maslen L, Merson L, Meynert AM, Moore SC, Noursadeghi M, Olanipekun M, Osagie A, Palmarini M, Palmieri C, Paxton WA, Pollakis G, Price N, Rambaut A, Robertson DL, Russell CD, Sancho-Shimizu V, Sands CJ, Scott JT, Sigfrid L, Solomon T, Sriskandan S, Stuart D, Summers C, Swann OV, Takats Z, Takis P, Tedder RS, Thompson AAR, Thomson EC, Thwaites RS, Turtle LCW, Zambon M, Drake TM, Fairfield CJ, Knight SR, Mclean KA, Murphy D, Norman L, Pius R, Shaw CA, Connor M, Dalton J, Gamble C, Girvan M, Halpin S, Harrison J, Jackson C, Lee J, Marsh L, Plotkin D, Roberts S, Saviciute E, Clohisey S, Hendry R, Knight S, Leeming G, Norris L, Scott-Brown J, Tait S, Wham M, Carson G, Grammatikopoulos T, McDonald SE, Shaw V, Keating S, Donegan C, Spencer RG, Donohue C, Griffiths F, Hardwick H, Oosthuyzen W, Rostron T, Waugh C, Sopp P, Knight JC, Fullerton JN, Coles M, Smith GL, Mentzer AJ, Peng Y, Dong Tet al., 2025,

  T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

  , Nature Communications, Vol: 16, ISSN: 2041-1723

  In 2022, a global mpox outbreak occurred, and remains a concern today. The T cell memory response to MPXV (monkeypox virus) infection has not been fully investigated. In this study, we evaluate this response in convalescent and MVA-BN (Modified Vaccinia Ankara - Bavarian Nordic) vaccinated individuals using VACV-infected cells. Strong CD8+ and CD4+ T cell responses are observed, and T cell responses are biased towards viral early expressed proteins. We identify seven immunodominant HLA-A*02:01 restricted MPXV-specific epitopes and focus our detailed phenotypic and scRNAseq analysis on the immunodominant HLA-A*02:01-G5R18-26-specific CD8+ T cell response. While tetramer+CD8+ T cells share similar differentiation and activation phenotypes, T cells from convalescent individuals show greater cytotoxicity, migratory potential to site of infection and TCR clonal expansion. Our data suggest that effective functional profiles of MPXV-specific memory T cells induced by Mpox infection may have an implication on the long-term protective responses to future infection.

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• Journal article
  Feary J, Yu Y, Kabir T, Schofield S, Bevan A, Askinyte V, Honan K, Emirali L, Rubbi A, Willis AE, Cullinan P, Anand S, Martins LMet al., 2025,

  Assessment of cancer biomarkers in the Grenfell firefighter cohort study

  , SCIENTIFIC REPORTS, Vol: 15, ISSN: 2045-2322
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• Conference paper
  Begg M, Pyle CJ, Patel N, Edwards MR, Londono-Hayes P, Shaw S, Johnston SLet al., 2025,

  APL-10456; An Adjuvanted Rhinovirus Clinical Vaccine Candidate Which Generates Cross-species Humoral and Th1-polarized Cellular Immunity

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Long MB, Hull RC, Gilmour A, Viligorska K, Richardson H, New BJM, Hennayake C, Galloway R, Johnson E, Mcintosh E, Eke Z, Lind H, Band M, Bandara H, Martin G, Aliberti S, Timothy A, Norwell J, Whitehouse J, Addy CL, Finney L, Mitchelmore P, Caskey SJ, Lord RW, Hill AT, Vendrell M, Polverino E, Marin A, Suarez-Cuartin G, Loebinger MR, Tunney M, Cartwright K, Hughes R, Digiandomenico A, Belvisi MG, Brailsford W, Haworth C, Sibila O, Stobo J, Chalmers JDet al., 2025,

  A Bispecific Monoclonal Antibody Targeting Psl and PcrV for Chronic Pseudomonas Aeruginosa Infection in Patients With Bronchiectasis: Results From a Randomized, Double-Blind Placebo-Controlled Trial (GREAT-2)

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Walsh SL, Kanavati F, Montiero M, Sherlock SP, Ble F, Ostridge K, Belvisi MG, Molyneaux P, Maher TM, Johnson SR, Saini G, Thillai Met al., 2025,

  Deep Learning-Based Quantitative CT and CT Phenotype Classification Independently Predict Mortality in Idiopathic Pulmonary Fibrosis, a Prospective Observational Cohort Study

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Walsh SL, Sherlock SP, Ostridge K, Ble F, Belvisi MG, Molyneaux PL, Maher TM, Montiero M, Kanavati F, Johnson SR, Saini G, Thillai Met al., 2025,

  Deep Learning-Based Short-Term Disease Progression Evaluation Supersedes Automated Baseline CT Phenotype in Predicting Outcomes in Idiopathic Pulmonary Fibrosis

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Johnson E, Cant EG, Bidgood L, Pembridge T, McIntosh E, Galloway R, Shuttleworth M, Hennayake C, Lind H, Viligorska K, Hull R, Headley DADL, Connell D, Liddicoat H, Platt A, Belvisi MG, Ostridge K, Azim A, Richardson H, Long MB, Shoemark A, Chalmers JDet al., 2025,

  Relationships Between Neutrophil Function, Cilia Function, and Microbiome Composition in Bronchiectasis: Interim Results From the Brilliant Study

  , 52nd Critical Care Congress of the Society-of-Critical-Care-Medicine (SCCM), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Craster A, Bussell E, Sherlock SP, Ostridge K, Ble F, Belvisi MG, Johnson SR, Saini G, Maher TM, Thillai M, Molyneaux PL, Walsh SLet al., 2025,

  Deep Learning-based Quantitative CT and Proteomics for Predicting Outcomes in Idiopathic Pulmonary Fibrosis

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Diop A, Hughes R, Muellerova H, Rapsomaniki E, Belvisi MG, Faner M, Reddel HK, Weinreich UMet al., 2025,

  Differences in the Characteristics and Outcomes by Sex in Patients With Physician-diagnosed Asthma and/or COPD in the NOVELTY Study

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Journal article
  Baraldi F, Mah J, Braddy-Green A, Almuhanna A, Bartlett-Pestell SWJ, Macleod MA, Ritchie AI, Wiseman DJ, Lopez R, Marion ANJM, Moreira LA, Shahbakhti H, Hoffman EA, Allinson JP, Papi A, Wedzicha JA, Finney Let al., 2025,

  The relationship between eosinophilic activation and mucus plug formation in COPD

  , American Journal of Respiratory and Critical Care Medicine, Vol: 211, ISSN: 1073-449X
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• Journal article
  Bartlett-Pestell S, Wong T, Wedzicha JA, 2025,

  Exacerbating the Problem: Chronic Obstructive Pulmonary Disease and Atrial Fibrillation

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 211, Pages: 695-697, ISSN: 1073-449X
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  • Citations: 1
• Journal article
  Finney LJ, Mah J, Duvall M, Wiseman D, Kamal F, Fenwick P, Ritchie AI, Kebadze T, Orton C, Bhavsar P, Allinson JP, Macleod M, Mackay AJ, Baraldi F, Kemp S, Singanayagam A, Johnston SL, Byrne AJ, Levy BD, Wedzicha JAet al., 2025,

  Select Airway Specialized Proresolving Mediators Are Associated with Recovery from Nonviral Chronic Obstructive Pulmonary Disease Exacerbations

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 211, Pages: 803-813, ISSN: 1073-449X
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  • Citations: 1
• Journal article
  Baraldi F, Bartlett-Pestle S, Allinson JP, Macleod M, Mah J, Bloom C, Brady-Green A, Marion A, Papi A, Wedzicha JA, Finney LJet al., 2025,

  Blood eosinophil count stability in COPD and the eosinophilic exacerbator phenotype

  , American Journal of Respiratory and Critical Care Medicine, Vol: 211, Pages: 870-872, ISSN: 1073-449X
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• Journal article
  Meghji J, Auld S, Bisson G, Khosa C, Masekela R, Navuluri N, Rachow Aet al., 2025,

  Post-tuberculosis lung disease: towards prevention, diagnosis and care

  , The Lancet Respiratory Medicine, Vol: 13, Pages: 460-472, ISSN: 2213-2600

  There is a growing body of data describing the high burden of respiratory sequelae seen among tuberculosis survivors, including children, adolescents, and adults. This group of sequelae are known as post-tuberculosis lung disease and include parenchymal damage, airway disease, and pulmonary vascular disease. It is thought that approximately half of pulmonary tuberculosis survivors have ongoing structural pathology, lung function impairment, or respiratory symptoms after the resolution of active disease. Post-tuberculosis lung disease has been associated with adverse patient outcomes, including persistent symptoms and functional impairment, ongoing health seeking, and impacts on income and employment. There is still much to understand about the epidemiology and nature of post-tuberculosis lung disease, but in this Review we focus on strategies for prevention, diagnosis, and care to inform the ongoing work of tuberculosis-affected communities, health-care providers, researchers, and policy makers. We summarise recent data, highlight evidence gaps, and suggest key research priorities for those working in the field.

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• Conference paper
  Ozoh OB, Mohammed J, Kayembe-Kitenge T, Amaral A, Lesosky M, Stolbrink M, Zurba L, Masekela R, Mortimer Ket al., 2025,

  Asthma Among African Adolescents: Findings From the Chronic Respiratory Disease Observatory for Africa (CHEST-Africa)

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Hughes R, McKellar D, Arad N, Muellerova H, Belvisi MG, Sansone RDO, Reddel HK, Papi Aet al., 2025,

  Coving Index: A Novel, Sensitive Spirometric Marker of Small Airways Obstruction10.1164/ajrccm.2025.211.Abstracts.A2566

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Tiddens H, Makani P, Bonte M, Cregan R, Rea D, Persaud T, Twomey E, McGrane S, Caudri D, Dodd JD, McKone EF, Semple T, Davies JC, McNally Pet al., 2025,

  Changes in Low Attenuation Regions and Arterial and Venous Blood Volume Distribution in Response to CFTR Modulator Therapy in People With Cystic Fibrosis

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Journal article
  Howlett P, Szram J, Feary J, 2025,

  Occupational lung disease: what the general physician needs to know

  , Clinical Medicine, Vol: 25, ISSN: 1470-2118

  Occupational exposures are a common and preventable cause of lung disease. About one in six cases of chronic obstructive pulmonary disease (COPD) and asthma worldwide are related to work.Early recognition of occupational lung disease improves outcomes. Doctors should ask about work history in patients with respiratory symptoms. This educational review article briefly outlines key clinical features, relevant to the general physician, of common occupational lung diseases seen in the UK. These conditions include work-related asthma, pneumoconioses, hypersensitivity pneumonitis and COPD.Referral to a specialist is recommended when an occupational cause is suspected. Most occupational lung diseases are preventable with adequate workplace safety measures and early medical attention.

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