BibTex format

author = {Östling, J and van, Geest M and Schofield, JPR and Jevnikar, Z and Wilson, S and Ward, J and Lutter, R and Shaw, DE and Bakke, PS and Caruso, M and Dahlen, S-E and Fowler, SJ and Horváth, I and Krug, N and Montuschi, P and Sanak, M and Sandström, T and Sun, K and Pandis, I and Auffray, C and Sousa, AR and Guo, Y and Adcock, IM and Howarth, P and Chung, KF and Bigler, J and Sterk, PJ and Skipp, PJ and Djukanovi, R and Vaarala, O and U-BIOPRED, Study Group},
doi = {10.1016/j.jaci.2019.03.027},
journal = {Journal of Allergy and Clinical Immunology},
pages = {1198--1213},
title = {IL-17-high asthma with features of a psoriasis immunophenotype},
url = {},
volume = {144},
year = {2019}

RIS format (EndNote, RefMan)

AB - BACKGROUND: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required. OBJECTIVE: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity. METHODS: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Gene signatures induced in vitro by interleukin-17 and interleukin-13 in bronchial epithelial cells were used to identify patients with interleukin-17-high and interleukin-13-high phenotypes of asthma. RESULTS: 22 out of 91 patients were identified with interleukin-17 and 9 patients with interleukin-13 gene signatures. The interleukin-17-high asthmatics were characterised by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis, the differentially expressed genes in interleukin-17-high patients were shared with those reported as altered in psoriasis lesions, and included genes regulating epithelial barrier function and defence mechanisms, such as interleukin-1β, interleukin-6, interleukin-8, and beta-defensin. CONCLUSION: The interleukin-17-high asthma phenotype, characterized by bronchial epithelial dysfunction, upregulated anti-microbial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway which should be considered as a biomarker for this phenotype in further studies, including clinical trials targeting interleukin-17.
AU - Östling,J
AU - van,Geest M
AU - Schofield,JPR
AU - Jevnikar,Z
AU - Wilson,S
AU - Ward,J
AU - Lutter,R
AU - Shaw,DE
AU - Bakke,PS
AU - Caruso,M
AU - Dahlen,S-E
AU - Fowler,SJ
AU - Horváth,I
AU - Krug,N
AU - Montuschi,P
AU - Sanak,M
AU - Sandström,T
AU - Sun,K
AU - Pandis,I
AU - Auffray,C
AU - Sousa,AR
AU - Guo,Y
AU - Adcock,IM
AU - Howarth,P
AU - Chung,KF
AU - Bigler,J
AU - Sterk,PJ
AU - Skipp,PJ
AU - Djukanovi,R
AU - Vaarala,O
AU - U-BIOPRED,Study Group
DO - 10.1016/j.jaci.2019.03.027
EP - 1213
PY - 2019///
SN - 0091-6749
SP - 1198
TI - IL-17-high asthma with features of a psoriasis immunophenotype
T2 - Journal of Allergy and Clinical Immunology
UR -
UR -
UR -
VL - 144
ER -