@article{Tregoning:2018:10.1016/j.jaci.2017.10.017,
author = {Tregoning, JS and Mallia, P and Webber, J and Gill, SK and Trujillo-Torralbo and Calderazzo, MA and Finney, L and Bakhsoliani, E and Farne, H and Singanayagam, A and Footitt, J and Hewitt, R and Kebadze and Aniscenko, J and Padmanaban, V and Molyneaux, PL and Adcock and Barnes, PJ and Ito, K and Elkin, SL and Kon, OM and Cookson, WO and MOffatt, MF and Johnston, SL},
doi = {10.1016/j.jaci.2017.10.017},
journal = {Journal of Allergy and Clinical Immunology},
pages = {815--823.e6},
title = {Role of airway glucose in bacterial infections in chronic obstructive pulmonary disease},
url = {http://dx.doi.org/10.1016/j.jaci.2017.10.017},
volume = {142},
year = {2018}
}

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TY  - JOUR
AB  - BackgroundPatients with chronic obstructive pulmonary disease (COPD) have increased susceptibility to respiratory tract infection, which contributes to disease progression and mortality, but mechanisms of increased susceptibility to infection remain unclear.ObjectivesThe aim of this study was to determine whether glucose concentrations were increased in airway samples (nasal lavage fluid, sputum, and bronchoalveolar lavage fluid) from patients with stable COPD and to determine the effects of viral infection on sputum glucose concentrations and how airway glucose concentrations relate to bacterial infection.MethodsWe measured glucose concentrations in airway samples collected from patients with stable COPD and smokers and nonsmokers with normal lung function. Glucose concentrations were measured in patients with experimentally induced COPD exacerbations, and these results were validated in patients with naturally acquired COPD exacerbations. Relationships between sputum glucose concentrations, inflammatory markers, and bacterial load were examined.ResultsSputum glucose concentrations were significantly higher in patients with stable COPD compared with those in control subjects without COPD. In both experimental virus-induced and naturally acquired COPD exacerbations, sputum and nasal lavage fluid glucose concentrations were increased over baseline values. There were significant correlations between sputum glucose concentrations and sputum inflammatory markers, viral load, and bacterial load. Airway samples with higher glucose concentrations supported more Pseudomonas aeruginosa growth in vitro.ConclusionsAirway glucose concentrations are increased in patients with stable COPD and further increased during COPD exacerbations. Increased airway glucose concentrations might contribute to bacterial infections in both patients with stable and those with exacerbated COPD. This has important implications for the development of nonantibiotic therapeutic strategies for the prev
AU  - Tregoning,JS
AU  - Mallia,P
AU  - Webber,J
AU  - Gill,SK
AU  - Trujillo-Torralbo
AU  - Calderazzo,MA
AU  - Finney,L
AU  - Bakhsoliani,E
AU  - Farne,H
AU  - Singanayagam,A
AU  - Footitt,J
AU  - Hewitt,R
AU  - Kebadze
AU  - Aniscenko,J
AU  - Padmanaban,V
AU  - Molyneaux,PL
AU  - Adcock
AU  - Barnes,PJ
AU  - Ito,K
AU  - Elkin,SL
AU  - Kon,OM
AU  - Cookson,WO
AU  - MOffatt,MF
AU  - Johnston,SL
DO  - 10.1016/j.jaci.2017.10.017
EP  - 823
PY  - 2018///
SN  - 0091-6749
SP  - 815
TI  - Role of airway glucose in bacterial infections in chronic obstructive pulmonary disease
T2  - Journal of Allergy and Clinical Immunology
UR  - http://dx.doi.org/10.1016/j.jaci.2017.10.017
UR  - https://www.sciencedirect.com/science/article/pii/S0091674917317438?via%3Dihub
UR  - http://hdl.handle.net/10044/1/55776
VL  - 142
ER  - 

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