@article{Polsek:2018:10.1016/j.neubiorev.2017.12.004,
author = {Polsek, D and Gildeh, N and Cash, D and Winsky-Sommerer, R and Williams, SCR and Turkheimer, F and Leschziner, GD and Morrell, MJ and Rosenzweig, I},
doi = {10.1016/j.neubiorev.2017.12.004},
journal = {Neuroscience and Biobehavioral Reviews},
pages = {142--149},
title = {Obstructive sleep apnoea and Alzheimer's disease: in search of shared pathomechanisms},
url = {http://dx.doi.org/10.1016/j.neubiorev.2017.12.004},
volume = {86},
year = {2018}
}

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TY  - JOUR
AB  - Alzheimer’s disease (AD) is a significant public health concern. The incidence continues to rise, and it is set to be over one million in the UK by 2025. The processes involved in the pathogenesis of AD have been shown to overlap with those found in cognitive decline in patients with Obstructive Sleep Apnoea (OSA). Currently, the standard treatment for OSA is Continuous Positive Airway Pressure. Adherence to treatment can, however, be an issue, especially in patients with dementia. Also, not all patients respond adequately, necessitating the use of additional treatments. Based on the body of data, we here suggest that excessive and prolonged neuronal activity might contribute to genesis and acceleration of both AD and OSA in the absence of appropriately structured sleep. Further, we argue that external factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain, and further promote disease progression. If this hypothesis is proven in future studies, it could have far-reaching clinical translational implications, as well as implications for future treatment strategies in OSA.
AU  - Polsek,D
AU  - Gildeh,N
AU  - Cash,D
AU  - Winsky-Sommerer,R
AU  - Williams,SCR
AU  - Turkheimer,F
AU  - Leschziner,GD
AU  - Morrell,MJ
AU  - Rosenzweig,I
DO  - 10.1016/j.neubiorev.2017.12.004
EP  - 149
PY  - 2018///
SN  - 0149-7634
SP  - 142
TI  - Obstructive sleep apnoea and Alzheimer's disease: in search of shared pathomechanisms
T2  - Neuroscience and Biobehavioral Reviews
UR  - http://dx.doi.org/10.1016/j.neubiorev.2017.12.004
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426224600012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60356
VL  - 86
ER  - 

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