@article{Sadaka:2018:10.2147/COPD.S163119,
author = {Sadaka, AS and Montgomery, AJ and Mourad, SM and Polkey, MI and Hopkinson, NS},
doi = {10.2147/COPD.S163119},
journal = {International Journal of COPD},
pages = {1607--1612},
title = {Exercise response to oxygen supplementation is not associated with survival in hypoxemic patients with obstructive lung disease},
url = {http://dx.doi.org/10.2147/COPD.S163119},
volume = {13},
year = {2018}
}

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TY  - JOUR
AB  - Purpose: Hypoxemia is associated with more severe lung disease and worse outcomes. In some patients with chronic obstructive lung diseases who desaturate on exertion, supplemental oxygen improves exercise capacity. The clinical significance of this exercise response to oxygen supplementation is not known.Patient and methods: We identified chronic obstructive lung disease patients at our center who underwent a six-minute walking test (6MWT) for ambulatory oxygen assessment and who desaturated breathing air and therefore had an additional walk test on supplemental oxygen, between August 2006 and June 2016. Responders were defined as walking >26m further with oxygen. Survival was determined up to 1st February 2017. We compared survival in oxygen responders and non-responders in patients with obstructive lung diseases.Results:  174 patients were included in the study, median age 70 years.  77(44.3%) of the patients were oxygen responders. Borg dyspnea score improved by 1.4(±1.4) units (P<0.0005) on oxygen. Median survival was 66 months with death occurring in 84(48.2%) patients. Kaplan-Meier analysis revealed no survival difference between both responders and non-responders (P=0.571). Cox regression analysis showed that more 6MWT desaturation, lower 6MWD on room air, male gender, lower hemoglobin and BMI were associated with higher mortality risk.Conclusion: Acute exercise response to supplemental oxygen is not associated with long-term survival in patients with obstructive lung disease. This supports the use of ambulatory oxygen treatment for symptomatic purposes only.
AU  - Sadaka,AS
AU  - Montgomery,AJ
AU  - Mourad,SM
AU  - Polkey,MI
AU  - Hopkinson,NS
DO  - 10.2147/COPD.S163119
EP  - 1612
PY  - 2018///
SN  - 1176-9106
SP  - 1607
TI  - Exercise response to oxygen supplementation is not associated with survival in hypoxemic patients with obstructive lung disease
T2  - International Journal of COPD
UR  - http://dx.doi.org/10.2147/COPD.S163119
UR  - http://hdl.handle.net/10044/1/57846
VL  - 13
ER  - 

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