BibTex format

author = {Ahmad, Y and Howard, J and Arnold, A and Shun-Shin, MJ and Cook, C and Petraco, R and Demir, O and Williams, L and Igelsias, J and Sutaria, N and Malik, I and Davies, J and Mayet, J and Francis, D and Sen, S},
doi = {eurheartj/ehy121},
journal = {European Heart Journal},
pages = {1638--1649},
title = {Patent foramen ovale closure versus medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials},
url = {},
volume = {39},
year = {2018}

RIS format (EndNote, RefMan)

AB - BackgroundThe efficacy of patent foramen ovale (PFO) closure for cryptogenic stroke has been controversial. We undertook a meta-analysis of randomised controlled trials (RCTs) comparing device closure with medical therapy to prevent recurrent stroke for patients with PFO.Methods and ResultsWe systematically identified all RCTs comparing device closure to medical therapy for cryptogenic stroke in patients with PFO. The primary efficacy endpoint was recurrent stroke, analysed on an intention-to-treat basis. The primary safety endpoint was new onset atrial fibrillation (AF). 5 studies (3440 patients) were included. 1829 patients were randomised to device closure and 1611 to medical therapy. Across all patients, PFO closure was superior to medical therapy for prevention of stroke (HR 0.32, 95% CI 0.13 to 0.82, p=0.018, I2 = 73.4%). The risk of AF was significantly increased with device closure (RR 4.54, 95% CI 2.17 to 9.48, p<0.001, heterogeneity I2 = 22.9%). In patients with large shunts, PFO closure was associated with a significant reduction in stroke (HR 0.33, 95% CI 0.16 to 0.72, p=0.005), whilst there was no significant reduction in stroke in patients with a small shunt (HR 0.90, 95% CI 0.50 to 1.60, p=0.712). There was no effect from the presence or absence of an atrial septal aneurysm on outcomes (p=0.994).ConclusionIn selected patients with cryptogenic stroke, PFO closure is superior to medical therapy for the prevention of further stroke: this is particularly true for patients with moderate-to-large shunts. Guidelines should be updated to reflect this.
AU - Ahmad,Y
AU - Howard,J
AU - Arnold,A
AU - Shun-Shin,MJ
AU - Cook,C
AU - Petraco,R
AU - Demir,O
AU - Williams,L
AU - Igelsias,J
AU - Sutaria,N
AU - Malik,I
AU - Davies,J
AU - Mayet,J
AU - Francis,D
AU - Sen,S
DO - eurheartj/ehy121
EP - 1649
PY - 2018///
SN - 1522-9645
SP - 1638
TI - Patent foramen ovale closure versus medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials
T2 - European Heart Journal
UR -
UR -
VL - 39
ER -