BibTex format

author = {Patel, HC and Rosen, SD and Hayward, C and Vassiliou, V and Smith, GC and Wage, RR and Bailey, J and Rajani, R and Lindsay, AC and Pennell, DJ and Underwood, SR and Prasad, SK and Mohiaddin, R and Gibbs, JSR and Lyon, AR and Di, Mario C},
doi = {10.1002/ejhf.502},
journal = {European Journal of Heart Failure},
pages = {703--712},
title = {Renal denervation in heart failure with preserved ejection fraction (RDF-PEF): a randomised controlled trial},
url = {},
volume = {18},
year = {2016}

RIS format (EndNote, RefMan)

AB - AimHeart failure with preserved ejection fraction (HFpEF) is associated with increased sympathetic nervous system (SNS) tone. Attenuating the SNS with renal denervation (RD) might be helpful and there are no data currently in humans with HFpEF.Methods and ResultsIn this single-centre, randomised, open-controlled study we included 25 patients with HFpEF (preserved left ventricular (LV) ejection fraction, left atrial (LA) dilatation or LV hypertrophy and raised B-type natriuretic peptide (BNP) or echocardiographic assessment of filling pressures). Patients were randomised (2:1) to RD with the Symplicity™ catheter or continuing medical therapy. The primary success criterion was not met in that there were no differences between groups at 12 months for Minnesota Living with Heart Failure Questionnaire score, peak oxygen uptake (VO2) on exercise, BNP, E/e’, LA volume index or LV mass index. A greater proportion of patients improved at three months in the RD group with respect to VO2 peak (56% vs 13%, P=0.025) and E/e’ (31% vs 13%, P=0.04). Change in estimated glomerular filtration rate was comparable between groups. Two patients required plain balloon angioplasty during the RD procedure to treat renal artery wall oedema.ConclusionThis study was terminated early due to difficulties in recruitment and was underpowered to detect whether RD improved the endpoints of: quality of life, exercise function, biomarkers and left heart remodelling. The procedure was safe in patients with HFpEF though two patients did require intra-procedure renal artery dilatation.
AU - Patel,HC
AU - Rosen,SD
AU - Hayward,C
AU - Vassiliou,V
AU - Smith,GC
AU - Wage,RR
AU - Bailey,J
AU - Rajani,R
AU - Lindsay,AC
AU - Pennell,DJ
AU - Underwood,SR
AU - Prasad,SK
AU - Mohiaddin,R
AU - Gibbs,JSR
AU - Lyon,AR
AU - Di,Mario C
DO - 10.1002/ejhf.502
EP - 712
PY - 2016///
SN - 1879-0844
SP - 703
TI - Renal denervation in heart failure with preserved ejection fraction (RDF-PEF): a randomised controlled trial
T2 - European Journal of Heart Failure
UR -
UR -
VL - 18
ER -