BibTex format

author = {Nielles-Vallespin, S and Khalique, Z and Ferreira, PF and de, Silva R and Scott, AD and Kilner, P and McGill, L-A and Giannakidis, A and Gatehouse, PD and Ennis, D and Aliotta, E and Al-Khalil, M and Kellman, P and Mazilu, D and Balaban, RS and Firmin, DN and Arai, AE and Pennell, DJ},
doi = {10.1016/j.jacc.2016.11.051},
journal = {Journal of the American College of Cardiology},
pages = {661--676},
title = {Assessment of myocardial microstructural dynamics by in vivo diffusion tensor cardiac magnetic resonance},
url = {},
volume = {69},
year = {2017}

RIS format (EndNote, RefMan)

AB - BackgroundCardiomyocytes are organized in microstructures termed sheetlets that reorientate during left ventricular thickening. Diffusion tensor cardiac magnetic resonance (DT-CMR) may enable noninvasive interrogation of in vivo cardiac microstructural dynamics. Dilated cardiomyopathy (DCM) is a condition of abnormal myocardium with unknown sheetlet function.ObjectivesThis study sought to validate in vivo DT-CMR measures of cardiac microstructure against histology, characterize microstructural dynamics during left ventricular wall thickening, and apply the technique in hypertrophic cardiomyopathy (HCM) and DCM.MethodsIn vivo DT-CMR was acquired throughout the cardiac cycle in healthy swine, followed by in situ and ex vivo DT-CMR, then validated against histology. In vivo DT-CMR was performed in 19 control subjects, 19 DCM, and 13 HCM patients.ResultsIn swine, a DT-CMR index of sheetlet reorientation (E2A) changed substantially (E2A mobility ∼46°). E2A changes correlated with wall thickness changes (in vivo r2 = 0.75; in situ r2 = 0.89), were consistently observed under all experimental conditions, and accorded closely with histological analyses in both relaxed and contracted states. The potential contribution of cyclical strain effects to in vivo E2A was ∼17%. In healthy human control subjects, E2A increased from diastole (18°) to systole (65°; p < 0.001; E2A mobility = 45°). HCM patients showed significantly greater E2A in diastole than control subjects did (48°; p < 0.001) with impaired E2A mobility (23°; p < 0.001). In DCM, E2A was similar to control subjects in diastole, but systolic values were markedly lower (40°; p < 0.001) with impaired E2A mobility (20°; p < 0.001).ConclusionsMyocardial microstructure dynamics can be characterized by in vivo DT-CMR. Sheetlet function was abnormal in DCM with altered systolic conformation and reduced mobility, contrasting with HCM, which showed reduced mobility with alte
AU - Nielles-Vallespin,S
AU - Khalique,Z
AU - Ferreira,PF
AU - de,Silva R
AU - Scott,AD
AU - Kilner,P
AU - McGill,L-A
AU - Giannakidis,A
AU - Gatehouse,PD
AU - Ennis,D
AU - Aliotta,E
AU - Al-Khalil,M
AU - Kellman,P
AU - Mazilu,D
AU - Balaban,RS
AU - Firmin,DN
AU - Arai,AE
AU - Pennell,DJ
DO - 10.1016/j.jacc.2016.11.051
EP - 676
PY - 2017///
SN - 0735-1097
SP - 661
TI - Assessment of myocardial microstructural dynamics by in vivo diffusion tensor cardiac magnetic resonance
T2 - Journal of the American College of Cardiology
UR -
UR -
VL - 69
ER -