@article{Byrne:2016:10.1038/mi.2016.92,
author = {Byrne, AJ and Weiss, M and Mathie, SA and Walker, S and Eames, HL and Saliba, D and Udalova, IA and Lloyd, CM},
doi = {10.1038/mi.2016.92},
journal = {Mucosal Immunology},
pages = {716--726},
title = {A critical role for IRF5 in regulating allergic airway inflammation},
url = {http://dx.doi.org/10.1038/mi.2016.92},
volume = {10},
year = {2016}
}
TY - JOUR
AB - Interferon regulatory factor 5 (IRF5) is a key transcription factor involved in the control of theexpression of pro-inflammatory cytokine and responses to infection, however its role in regulatingpulmonary immune responses to allergen is unknown. We used genetic ablation, adenoviralvector-driven overexpression and adoptive transfer approaches to interrogate the role of IRF5 inpulmonary immunity and during challenge with the aero-allergen, house dust mite. Global IRF5deficiency resulted in impaired lung function and extracellular matrix (ECM) deposition. IRF5was also essential for effective responses to inhaled allergen, controlling airway hyper-responsiveness, mucus secretion and eosinophilic inflammation. Adoptive transfer of IRF5-deficient alveolar macrophages into the WT pulmonary milieu was sufficient to drive airwayhyper-reactivity, at baseline or following antigen challenge. These data identify IRF5-expressingmacrophages as a key component of the immune defence of the airways. Manipulation of IRF5activity in the lung could therefore be a viable strategy for the redirection of pulmonary immuneresponses and thus, the treatment of lung disorders.
AU - Byrne,AJ
AU - Weiss,M
AU - Mathie,SA
AU - Walker,S
AU - Eames,HL
AU - Saliba,D
AU - Udalova,IA
AU - Lloyd,CM
DO - 10.1038/mi.2016.92
EP - 726
PY - 2016///
SN - 1935-3456
SP - 716
TI - A critical role for IRF5 in regulating allergic airway inflammation
T2 - Mucosal Immunology
UR - http://dx.doi.org/10.1038/mi.2016.92
UR - http://hdl.handle.net/10044/1/41192
VL - 10
ER -