Citation

BibTex format

@article{Birdsey:2015:10.1016/j.devcel.2014.11.016,
author = {Birdsey, GM and Shah, AV and Dufton, N and Reynolds, LE and Osuna, Almagro L and Yang, Y and Aspalter, IM and Khan, ST and Mason, JC and Dejana, E and Göttgens, B and Hodivala-Dilke, K and Gerhardt, H and Adams, RH and Randi, AM},
doi = {10.1016/j.devcel.2014.11.016},
journal = {Developmental cell},
pages = {82--96},
title = {The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling.},
url = {http://dx.doi.org/10.1016/j.devcel.2014.11.016},
volume = {32},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Blood vessel stability is essential for embryonic development; in the adult, many diseases are associated with loss of vascular integrity. The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity. We show that constitutive endothelial deletion of ERG (Erg(cEC-KO)) in mice causes embryonic lethality with vascular defects. Inducible endothelial deletion of ERG (Erg(iEC-KO)) results in defective physiological and pathological angiogenesis in the postnatal retina and tumors, with decreased vascular stability. ERG controls the Wnt/β-catenin pathway by promoting β-catenin stability, through signals mediated by VE-cadherin and the Wnt receptor Frizzled-4. Wnt signaling is decreased in ERG-deficient endothelial cells; activation of Wnt signaling with lithium chloride, which stabilizes β-catenin levels, corrects vascular defects in Erg(cEC-KO) embryos. Finally, overexpression of ERG in vivo reduces permeability and increases stability of VEGF-induced blood vessels. These data demonstrate that ERG is an essential regulator of angiogenesis and vascular stability through Wnt signaling.
AU - Birdsey,GM
AU - Shah,AV
AU - Dufton,N
AU - Reynolds,LE
AU - Osuna,Almagro L
AU - Yang,Y
AU - Aspalter,IM
AU - Khan,ST
AU - Mason,JC
AU - Dejana,E
AU - Göttgens,B
AU - Hodivala-Dilke,K
AU - Gerhardt,H
AU - Adams,RH
AU - Randi,AM
DO - 10.1016/j.devcel.2014.11.016
EP - 96
PY - 2015///
SN - 1534-5807
SP - 82
TI - The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling.
T2 - Developmental cell
UR - http://dx.doi.org/10.1016/j.devcel.2014.11.016
VL - 32
ER -