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Journal articleGUTTERIDGE JMC, BEARD APC, QUINLAN GJ, 1985,
CATALASE ENHANCES DAMAGE TO DNA BY BLEOMYCIN-IRON(II) - THE ROLE OF HYDROXYL RADICALS
, BIOCHEMISTRY INTERNATIONAL, Vol: 10, Pages: 441-449, ISSN: 0158-5231- Cite
- Citations: 5
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Journal articleWILKINS MR, 1985,
ENDOGENOUS DIGITALIS - A REVIEW OF THE EVIDENCE
, TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 6, Pages: 286-288, ISSN: 0165-6147- Author Web Link
- Cite
- Citations: 15
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Journal articleWILKINS MR, KENDALL MJ, WADE OL, 1985,
WITHERING,WILLIAM AND DIGITALIS, 1785 TO 1985
, BRITISH MEDICAL JOURNAL, Vol: 290, Pages: 7-8, ISSN: 0959-8138- Author Web Link
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- Citations: 15
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Journal articleZAMAN R, JACK DB, WILKINS MR, et al., 1985,
LACK OF EFFECT OF LIVER-DISEASE ON THE PHARMACOKINETICS OF ACEBUTOLOL AND DIACETOLOL - A SINGLE DOSE STUDY
, BIOPHARMACEUTICS & DRUG DISPOSITION, Vol: 6, Pages: 131-137, ISSN: 0142-2782- Cite
- Citations: 12
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Journal articleGUTTERIDGE JMC, QUINLAN GJ, 1985,
FREE-RADICAL DAMAGE TO DEOXYRIBOSE BY ANTHRACYCLINE, AUREOLIC ACID AND AMINOQUINONE ANTITUMOUR ANTIBIOTICS - AN ESSENTIAL REQUIREMENT FOR IRON, SEMIQUINONES AND HYDROGEN-PEROXIDE
, BIOCHEMICAL PHARMACOLOGY, Vol: 34, Pages: 4099-4103, ISSN: 0006-2952- Cite
- Citations: 41
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Journal articleJack DB, Wilkins MR, Laugher SJ, et al., 1985,
A clinical and pharmacokinetic study of ciprofloxacin administered chronically as i.v. bolus doses to young healthy volunteers
, Recent Advances in Chemotherapy, Pages: 1587-1588 -
Journal articleFranklyn JA, Wilkins MR, Wilkinson R, et al., 1985,
The effect of propranolol on circulating thyroid hormone measurements in thyrotoxic and euthyroid subjects
, Vol: 108, Pages: 351-355 -
Journal articleWilkins MR, Woods KL, Jack DB, et al., 1985,
Separate and combined effects of nadolol and nifedipine on the cardiac response to exercise
, European Journal of Clinical Pharmacology, Vol: 28, Pages: 113-117 -
Journal articleZaman R, Kendall MJ, Wilkins MR, et al., 1985,
Effect of liver disease on the pharmacokinetics of acebutolol and diacetolol
, Biopharmaceutics and Drug Disposition, Vol: 6, Pages: 131-137 -
Journal articleGUTTERIDGE JMC, QUINLAN GJ, CLARK I, et al., 1985,
ALUMINUM SALTS ACCELERATE PEROXIDATION OF MEMBRANE-LIPIDS STIMULATED BY IRON SALTS
, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 835, Pages: 441-447, ISSN: 0006-3002- Cite
- Citations: 322
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Journal articleWilkins MR, Franklyn JA, Woods KL, et al., 1985,
Effect of propranolol on thyroid homeostasis of healthy volunteers
, Postgraduate Medical Journal, Vol: 61, Pages: 391-395 -
Journal articleWeissberg PJ, West MJ, Wilkins MR, et al., 1984,
Effects of changes in dietary sodium intake in normotensive subjects with and without a genetic predisposition to essential hypertension
, Journal of Hypertension, Vol: 2, Pages: 511-513 -
Journal articleTHOMAS AH, QUINLAN GJ, GUTTERIDGE JMC, 1984,
ASSAY OF DOXORUBICIN AND 4'-EPIDOXORUBICIN BY REVERSED-PHASE ION-PAIR CHROMATOGRAPHY
, JOURNAL OF CHROMATOGRAPHY, Vol: 299, Pages: 489-494, ISSN: 0021-9673- Author Web Link
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- Citations: 14
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Journal articleZaman R, Wilkins MR, Kendall MJ, et al., 1984,
The effect of food and alcohol on the pharmacokinetics of acebutolol and its metabolite diacetolol
, Biopharmaceutics and Drug Disposition, Vol: 5, Pages: 91-95 -
Journal articleWILKINS MR, KENDALL MJ, 1984,
BETA-ADRENOCEPTOR BLOCKING-DRUGS AND THE ELDERLY
, JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, Vol: 18, Pages: 42-45, ISSN: 0035-8819- Author Web Link
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- Citations: 9
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Journal articleGUTTERIDGE JMC, QUINLAN GJ, WILKINS S, 1984,
MITOMYCIN C-INDUCED DEOXYRIBOSE DEGRADATION INHIBITED BY SUPEROXIDE-DISMUTASE - A REACTION INVOLVING IRON, HYDROXYL AND SEMIQUINONE RADICALS
, FEBS LETTERS, Vol: 167, Pages: 37-41, ISSN: 0014-5793- Author Web Link
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- Citations: 46
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Journal articleWILKINS MR, WEST MJ, WEISSBERG PL, 1984,
AMIODARONE AND PLASMA DIGOXIN LEVELS
, LANCET, Vol: 1, Pages: 1180-1180, ISSN: 0140-6736 -
Journal articleGutteridge JM, Quinlan GJ, 1983,
Malondialdehyde formation from lipid peroxides in the thiobarbituric acid test: the role of lipid radicals, iron salts, and metal chelators.
, J Appl Biochem, Vol: 5, Pages: 293-299, ISSN: 0161-7354Most of the chromogen formed when peroxidized material is heated with thiobarbituric acid (TBA) can be ascribed to a colored complex formed between malondialdehyde (MDA) and TBA. Even when little MDA is present, large amounts of MDA-TBA adduct can be formed. This is because lipid peroxides break down to release MDA during the test conditions. Iron is not essential for the breakdown of the peroxides but is essential for the formation of TBA reactivity. This can be related to the ability of iron to decompose lipid peroxides with the release of peroxy radicals, which are precursors of MDA. These peroxy radicals, when released, can initiate further peroxidation during the heating stage of the TBA test. Fatty acids in the absence of lipid peroxides do not undergo significant peroxidation during the acid-heating stage of the TBA test.
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Journal articleGUTTERIDGE JMC, BEARD APC, QUINLAN GJ, 1983,
SUPEROXIDE-DEPENDENT LIPID-PEROXIDATION - PROBLEMS WITH THE USE OF CATALASE AS A SPECIFIC PROBE FOR FENTON-DERIVED HYDROXYL RADICALS
, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 117, Pages: 901-907, ISSN: 0006-291X- Cite
- Citations: 30
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Journal articleKendall MJ, Woods KL, Wilkins MR, 1982,
Responsiveness to beta adrenergic stimulation: the effects of age are cardioselective
, British Journal of Clinical Pharmacology, Vol: 14, Pages: 821-826
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