The human heart in health and disease, one cell at a time
Dr Michela Noseda
Deadline: Wednesday 4 September 2019
Three year PhD funded through the National Heart and Lung Institute, starting October 2019.
Applications are invited from candidates with a Master’s degree (Merit and above) in Biomedical Sciences, Immunology or a related discipline, for a three year PhD.
The studentship will be funded for 3.5 years with a tax free bursary of £18,000 p.a. Tuition fees at the Home/EU rate will also be paid.
Summary of Research
Cardiovascular disease is a daunting health care emergency globally, with heart failure costing over $100 billion USD a year worldwide and the only definitive cure being heart transplantation, there is an obvious unmet need. Following damage, the progressive loss of cardiac function derives from largely unknown molecular, cellular and interstitial modifications that manifest clinically as changes in the size, mass, and geometry of the heart, known as cardiac remodelling. The objectives of the research group with whom the student will work are to develop and apply leading-edge single cell ‘omics’ technologies to address clinically relevant and basic biological questions pertinent to the cardiovascular system. The long-term goals are to:
- Develop novel molecular tools as dynamic biomarkers of cardiac remodelling.
- Identify therapeutic targets to prevent progression of cardiac disease to heart failure.
The central hypothesis underlying this and future studies is that not all cardiac remodelling in heart failure is created equal and differs in regard to transcriptional activation and changes in subpopulation prevalence that are specific to its aetiology. A grant of approximatley €1,850,000 was awarded with joint contributions from the British Heart Foundation and German Centre for Cardiovascular Research (DZHK) to define the cellular and molecular landscape of healthy reference cardiac tissue and the changes occurring in cardiomyopathies. Selected targets will be validated using human iPSC-derived cardiomyocytes (hiPS-CMs). By studying human disease samples and hiPS-CMs, this project will aim to define and validate paracrine circuits that impinge on cardiomyocytes function and survival.
Imperial College London is a world-class university providing outstanding opportunities for research students. The Graduate School ensures a full training programme in research and also transferable skills, the quality of which has been repeatedly recognised in the Times Higher Education (THE) Awards.
The student will be based in the section of Cardiac Function and work closely with the Cardiac Genetics groups within the National Heart and Lung Institute, a lively environment bringing together world-leaders in cardiovascular biology, genetics and clinicians. The projects evolve in an interdisciplinary fashion with particularly close exchanges with the Chemistry and Biomaterial Departments. A proactive approach with collaborators from the Cellular Genetics at the Welcome Sanger Institute as well as the Max-Delbrück-Centrum für Molekulare Medizin in Berlin and Harvard University will further ensure constant interaction with an international and energetic scientific network.
We are looking for an enthusiastic, engaged and dedicated member of the team with initiative and willingness to tackle challenging scientific questions to further the understanding of cardiovascular disease.
How to Apply
Applicants must hold, or expect to obtain, a first or upper second-class undergraduate degree or UK equivalent, along with a Master's, both in an appropriate subject from a recognised academic institution.
To apply please email the following information to Dr Michela Noseda by email at email@example.com.
- Curriculum Vitae
- One page personal statement
- Name, address, telephone number or email of at least two academic referees.
Application deadline: Wednesday 4 September 2019.
Please note that candidates must fulfil College admissions criteria.
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