@article{Mura:2014:10.1038/onc.2014.428,
author = {Mura, M and Hopkins, TG and Michael, T and Abd-Latip, N and Weir, J and Aboagye, E and Mauri, F and Jameson, C and Sturge, J and Gabra, H and Bushell, M and Willis, AE and Curry, E and Blagden, SP},
doi = {10.1038/onc.2014.428},
journal = {Oncogene},
pages = {5025--5036},
title = {LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression},
url = {http://dx.doi.org/10.1038/onc.2014.428},
volume = {34},
year = {2014}
}

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TY  - JOUR
AB  - RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show that LARP1 is complexed to 3000 mRNAs enriched for cancer pathways. A prominent member of the LARP1 interactome is mTOR whose mRNA transcript is stabilized by LARP1. At a functional level, we show that LARP1 promotes cell migration, invasion, anchorage-independent growth and in vivo tumorigenesis. Furthermore, we show that LARP1 expression is elevated in epithelial cancers such as cervical and non-small cell lung cancers, where its expression correlates with disease progression and adverse prognosis, respectively. We therefore conclude that, through the post-transcriptional regulation of genes such as mTOR within cancer pathways, LARP1 contributes to cancer progression.
AU  - Mura,M
AU  - Hopkins,TG
AU  - Michael,T
AU  - Abd-Latip,N
AU  - Weir,J
AU  - Aboagye,E
AU  - Mauri,F
AU  - Jameson,C
AU  - Sturge,J
AU  - Gabra,H
AU  - Bushell,M
AU  - Willis,AE
AU  - Curry,E
AU  - Blagden,SP
DO  - 10.1038/onc.2014.428
EP  - 5036
PY  - 2014///
SN  - 1476-5594
SP  - 5025
TI  - LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
T2  - Oncogene
UR  - http://dx.doi.org/10.1038/onc.2014.428
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361693300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/43636
VL  - 34
ER  - 

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