Imperial College London

DrArkhatAbzhanov

Faculty of Natural SciencesDepartment of Life Sciences (Silwood Park)

Reader in Evolution and Developmental Genetics
 
 
 
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Contact

 

a.abzhanov

 
 
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Location

 

Munro 2.15MunroSilwood Park

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Summary

 

Publications

Publication Type
Year
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69 results found

Camacho J, Moon R, Seetahal J, Tabin C, Abzhanov Aet al., 2019, Origins of Craniofacial Diversity in New World Leaf-Nosed Bats at the Developmental, Cellular and Genetic level, Publisher: WILEY, Pages: S93-S93, ISSN: 0362-2525

Conference paper

Morris ZS, Abzhanov A, Pierce SE, 2019, Correlations between Developmental, Ecological, and Evolutionary Axes of Cranial Shape Variation in Extant Crocodylians and the Pseudosuchian Fossil Record, Publisher: WILEY, Pages: S186-S187, ISSN: 0362-2525

Conference paper

Morris ZS, Pierce SE, Abzhanov A, 2019, The role of craniofacial growth zones in shaping crocodylian snouts, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E162-E162, ISSN: 1540-7063

Conference paper

Morris ZS, Vliet KA, Abzhanov A, Pierce SEet al., 2019, Heterochronic shifts and conserved embryonic shape underlie crocodylian craniofacial disparity and convergence, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 286, ISSN: 0962-8452

Journal article

Camacho J, Tabin CJ, Abzhanov A, 2018, Exploring adaptive and novel traits of bat faces through morphometrics and developmental genetics, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E28-E28, ISSN: 1540-7063

Conference paper

Abzhanov A, 2017, The old and new faces of morphology: the legacy of D'Arcy Thompson's 'theory of transformations' and 'laws of growth', DEVELOPMENT, Vol: 144, Pages: 4284-4297, ISSN: 0950-1991

Journal article

Fabbri M, Koch NM, Pritchard AC, Hanson M, Hoffman E, Bever GS, Balanoff AM, Morris ZS, Field DJ, Camacho J, Rowe TB, Norell MA, Smith RM, Abzhanov A, Bhullar B-ASet al., 2017, The skull roof tracks the brain during the evolution and development of reptiles including birds, NATURE ECOLOGY & EVOLUTION, Vol: 1, Pages: 1543-1550, ISSN: 2397-334X

Journal article

Morris ZS, Pierce SE, Abzhanov A, 2017, Craniofacial growth zones and modularity in Amniota: insight from the model crocodylian, Alligator mississippiensis., Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E355-E355, ISSN: 1540-7063

Conference paper

Abzhanov A, 2017, Evolution of the Animal Face: from Principles to Mechanisms, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E189-E189, ISSN: 1540-7063

Conference paper

Tokita M, Yano W, James HF, Abzhanov Aet al., 2016, Cranial shape evolution in adaptive radiations of birds: comparative morphometrics of Darwin's finches and Hawaiian honeycreepers, Philosophical Transactions B: Biological Sciences, Vol: 372, ISSN: 0962-8436

Adaptive radiation is the rapid evolution of morphologically and ecologically diverse species from a single ancestor. The two classic examples of adaptive radiation are Darwin's finches and the Hawaiian honeycreepers, which evolved remarkable levels of adaptive cranial morphological variation. To gain new insights into the nature of their diversification, we performed comparative three-dimensional geometric morphometric analyses based on X-ray microcomputed tomography (µCT) scanning of dried cranial skeletons. We show that cranial shapes in both Hawaiian honeycreepers and Coerebinae (Darwin's finches and their close relatives) are much more diverse than in their respective outgroups, but Hawaiian honeycreepers as a group display the highest diversity and disparity of all other bird groups studied. We also report a significant contribution of allometry to skull shape variation, and distinct patterns of evolutionary change in skull morphology in the two lineages of songbirds that underwent adaptive radiation on oceanic islands. These findings help to better understand the nature of adaptive radiations in general and provide a foundation for future investigations on the developmental and molecular mechanisms underlying diversification of these morphologically distinguished groups of birds.This article is part of the themed issue ‘Evo-devo in the genomics era, and the origins of morphological diversity’.

Journal article

Camacho J, Heyde A, Bhullar BAS, Haelewaters D, Simmons NB, Abzhanov Aet al., 2016, The evolution and development of diverse and adaptive skull shapes in New World leaf-nosed bats, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E30-E30, ISSN: 1540-7063

Conference paper

Namkoong B, Guven S, Ramesan S, Liaudanskaya V, Abzhanov A, Demirci Uet al., 2015, Recapitulating cranial osteogenesis with neural crest cells in 3-D microenvironments, Acta Biomaterialia, Vol: 31, Pages: 301-311, ISSN: 1878-7568

The experimental systems that recapitulate the complexity of native tissues and enable precise control over the microenvironment are becoming essential for the pre-clinical tests of therapeutics and tissue engineering. Here, we described a strategy to develop an in vitro platform to study the developmental biology of craniofacial osteogenesis. In this study, we directly osteo-differentiated cranial neural crest cells (CNCCs) in a 3-D in vitro bioengineered microenvironment. Cells were encapsulated in the gelatin-based photo-crosslinkable hydrogel and cultured up to three weeks. We demonstrated that this platform allows efficient differentiation of p75 positive CNCCs to cells expressing osteogenic markers corresponding to the sequential developmental phases of intramembranous ossification. During the course of culture, we observed a decrease in the expression of early osteogenic marker Runx2, while the other mature osteoblast and osteocyte markers such as Osterix, Osteocalcin, Osteopontin and Bone sialoprotein increased. We analyzed the ossification of the secreted matrix with alkaline phosphatase and quantified the newly secreted hydroxyapatite. The Field Emission Scanning Electron Microscope (FESEM) images of the bioengineered hydrogel constructs revealed the native-like osteocytes, mature osteoblasts, and cranial bone tissue morphologies with canaliculus-like intercellular connections. This platform provides a broadly applicable model system to potentially study diseases involving primarily embryonic craniofacial bone disorders, where direct diagnosis and adequate animal disease models are limited.

Journal article

Namkong B, Guven S, Ramesan S, Liaudanskaya V, Abzhanov A, Demirci Uet al., 2015, Recapitulating Cranial Osteogenesis with Neural Crest Cells in 3-d Microenvironments, 4th TERMIS World Congress, Publisher: MARY ANN LIEBERT, INC, Pages: S337-S337, ISSN: 1937-3341

Conference paper

Bhullar B-AS, Morris ZS, Sefton EM, Tok A, Tokita M, Namkoong B, Camacho J, Burnham DA, Abzhanov Aet al., 2015, A molecular mechanism for the origin of a key evolutionary innovation, the bird beak and palate, revealed by an integrative approach to major transitions in vertebrate history, EVOLUTION, Vol: 69, Pages: 1665-1677, ISSN: 0014-3820

Journal article

Abzhanov A, 2015, Evolution of the Animal Face: from Principles to Mechanisms, Experimental Biology Meeting, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638

Conference paper

Sanger TJ, Seav SM, Tokita M, Langerhans RB, Ross LM, Losos JB, Abzhanov Aet al., 2014, The oestrogen pathway underlies the evolution of exaggerated male cranial shapes in Anolis lizards, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 281, ISSN: 0962-8452

Journal article

Fritz JA, Brancale J, Tokita M, Burns KJ, Hawkins MB, Abzhanov A, Brenner MPet al., 2014, Shared developmental programme strongly constrains beak shape diversity in songbirds, NATURE COMMUNICATIONS, Vol: 5, ISSN: 2041-1723

Journal article

Abzhanov A, 2013, von Baer's law for the ages: lost and found principles of developmental evolution, TRENDS IN GENETICS, Vol: 29, Pages: 712-722, ISSN: 0168-9525

Journal article

Weeks O, Bhullar B-AS, Abzhanov A, 2013, Molecular characterization of dental development in a toothed archosaur, the American alligator Alligator mississippiensis, EVOLUTION & DEVELOPMENT, Vol: 15, Pages: 393-405, ISSN: 1520-541X

Journal article

Lyson TR, Bhullar B-AS, Bever GS, Joyce WG, de Queiroz K, Abzhanov A, Gauthier JAet al., 2013, Homology of the enigmatic nuchal bone reveals novel reorganization of the shoulder girdle in the evolution of the turtle shell, EVOLUTION & DEVELOPMENT, Vol: 15, Pages: 317-325, ISSN: 1520-541X

Journal article

Sanger TJ, Sherratt E, McGlothlin JW, Brodie ED, Losos JB, Abzhanov Aet al., 2013, CONVERGENT EVOLUTION OF SEXUAL DIMORPHISM IN SKULL SHAPE USING DISTINCT DEVELOPMENTAL STRATEGIES, EVOLUTION, Vol: 67, Pages: 2180-2193, ISSN: 0014-3820

Journal article

Bhullar B-AS, Marugan-Lobon J, Racimo F, Bever GS, Rowe TB, Norell MA, Abzhanov Aet al., 2013, The evolution and development of the archosaurian head and the origin of the bird skull, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E16-E16, ISSN: 1540-7063

Conference paper

Abzhanov A, 2013, Developmental mechanisms for morphological evolution, Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638

Conference paper

Rands CM, Darling A, Fujita M, Kong L, Webster MT, Clabaut C, Emes RD, Heger A, Meader S, Hawkins MB, Eisen MB, Teiling C, Affourtit J, Boese B, Grant PR, Grant BR, Eisen JA, Abzhanov A, Ponting CPet al., 2013, Insights into the evolution of Darwin’s finches from comparative analysis of the Geospiza magnirostris genome sequence, BMC Genomics, Vol: 14, ISSN: 1471-2164

BACKGROUND: A classical example of repeated speciation coupled with ecological diversification is the evolution of 14 closely related species of Darwin's (Galápagos) finches (Thraupidae, Passeriformes). Their adaptive radiation in the Galápagos archipelago took place in the last 2-3 million years and some of the molecular mechanisms that led to their diversification are now being elucidated. Here we report evolutionary analyses of genome of the large ground finch, Geospiza magnirostris. RESULTS: 13,291 protein-coding genes were predicted from a 991.0 Mb G. magnirostris genome assembly. We then defined gene orthology relationships and constructed whole genome alignments between the G. magnirostris and other vertebrate genomes. We estimate that 15% of genomic sequence is functionally constrained between G. magnirostris and zebra finch. Genic evolutionary rate comparisons indicate that similar selective pressures acted along the G. magnirostris and zebra finch lineages suggesting that historical effective population size values have been similar in both lineages. 21 otherwise highly conserved genes were identified that each show evidence for positive selection on amino acid changes in the Darwin's finch lineage. Two of these genes (Igf2r and Pou1f1) have been implicated in beak morphology changes in Darwin's finches. Five of 47 genes showing evidence of positive selection in early passerine evolution have cilia related functions, and may be examples of adaptively evolving reproductive proteins. CONCLUSIONS: These results provide insights into past evolutionary processes that have shaped G. magnirostris genes and its genome, and provide the necessary foundation upon which to build population genomics resources that will shed light on more contemporaneous adaptive and non-adaptive processes that have contributed to the evolution of the Darwin's finches.

Journal article

Mallarino R, Campas O, Fritz JA, Burns KJ, Weeks OG, Brenner MP, Abzhanov Aet al., 2012, Closely related bird species demonstrate flexibility between beak morphology and underlying developmental programs, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 16222-16227, ISSN: 0027-8424

Journal article

Bhullar B-AS, Marugan-Lobon J, Racimo F, Bever GS, Rowe TB, Norell MA, Abzhanov Aet al., 2012, Birds have paedomorphic dinosaur skulls, NATURE, Vol: 487, Pages: 223-226, ISSN: 0028-0836

Journal article

Sanger TJ, Mahler DL, Abzhanov A, Losos JBet al., 2012, ROLES FOR MODULARITY AND CONSTRAINT IN THE EVOLUTION OF CRANIAL DIVERSITY AMONG ANOLIS LIZARDS, EVOLUTION, Vol: 66, Pages: 1525-1542, ISSN: 0014-3820

Journal article

Abzhanov A, 2012, Pecking at the Origin of Morphological Diversity: Insights from Darwin's Finches and Other Birds, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E1-E1, ISSN: 1540-7063

Conference paper

Sanger TJ, Seav SM, Losos JB, Abzhanov Aet al., 2012, Evolution and Development of Sexual Skull Dimorphism among Anolis lizards, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E153-E153, ISSN: 1540-7063

Conference paper

St John JA, Braun EL, Isberg SR, Miles LG, Chong AY, Gongora J, Dalzell P, Moran C, Bed'Hom B, Abzhanov A, Burgess SC, Cooksey AM, Castoe TA, Crawford NG, Densmore LD, Drew JC, Edwards SV, Faircloth BC, Fujita MK, Greenwold MJ, Hoffmann FG, Howard JM, Iguchi T, Janes DE, Khan SY, Kohno S, de Koning APJ, Lance SL, McCarthy FM, McCormack JE, Merchant ME, Peterson DG, Pollock DD, Pourmand N, Raney BJ, Roessler KA, Sanford JR, Sawyer RH, Schmidt CJ, Triplett EW, Tuberville TD, Venegas-Anaya M, Howard JT, Jarvis ED, Guillette LJ, Glenn TC, Green RE, Ray DAet al., 2012, Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes, Genome Biology, Vol: 13, ISSN: 1474-760X

Journal article

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