Imperial College London
Alternate

DrArkhatAbzhanov

Faculty of Natural Sciences, Department of Life Sciences (Silwood Park)

Reader in Evolution and Developmental Genetics
 
 
 
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Contact

 

a.abzhanov

 
 
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Location

 

Munro 2.15MunroSilwood Park

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Summary

 

Publications

Citation

BibTex format

@article{Camacho:2020:10.1186/s13227-020-00156-9,
author = {Camacho, J and Moon, R and Smith, SK and Lin, JD and Randolph, C and Rasweiler, JJ and Behringer, RR and Abzhanov, A},
doi = {10.1186/s13227-020-00156-9},
journal = {EvoDevo},
title = {Differential cellular proliferation underlies heterochronic generation of cranial diversity in phyllostomid bats},
url = {http://dx.doi.org/10.1186/s13227-020-00156-9},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundSkull diversity in the neotropical leaf-nosed bats (Phyllostomidae) evolved through a heterochronic process called peramorphosis, with underlying causes varying by subfamily. The nectar-eating (subfamily Glossophaginae) and blood-eating (subfamily Desmondontinae) groups originate from insect-eating ancestors and generate their uniquely shaped faces and skulls by extending the ancestral ontogenetic program, appending new developmental stages and demonstrating peramorphosis by hypermorphosis. However, the fruit-eating phyllostomids (subfamilies Carollinae and Stenodermatinae) adjust their craniofacial development by speeding up certain developmental processes, displaying peramorphosis by acceleration. We hypothesized that these two forms of peramorphosis detected by our morphometric studies could be explained by differential growth and investigated cell proliferation during craniofacial morphogenesis.ResultsWe obtained cranial tissues from four wild-caught bat species representing a range of facial diversity and labeled mitotic cells using immunohistochemistry. During craniofacial development, all bats display a conserved spatiotemporal distribution of proliferative cells with distinguishable zones of elevated mitosis. These areas were identified as modules by the spatial distribution analysis. Ancestral state reconstruction of proliferation rates and patterns in the facial module between species provided support, and a degree of explanation, for the developmental mechanisms underlying the two models of peramorphosis. In the long-faced species, Glossophaga soricina, whose facial shape evolved by hypermorphosis, cell proliferation rate is maintained at lower levels and for a longer period of time compared to the outgroup species Miniopterus natalensis. In both species of studied short-faced fruit bats, Carollia perspicillata and Artibeus jamaicensis, which evolved under the acceleration model, cell proliferation rate is increased compared to the outgroup.Conc
AU  - Camacho,J
AU  - Moon,R
AU  - Smith,SK
AU  - Lin,JD
AU  - Randolph,C
AU  - Rasweiler,JJ
AU  - Behringer,RR
AU  - Abzhanov,A
DO  - 10.1186/s13227-020-00156-9
PY  - 2020///
SN  - 2041-9139
TI  - Differential cellular proliferation underlies heterochronic generation of cranial diversity in phyllostomid bats
T2  - EvoDevo
UR  - http://dx.doi.org/10.1186/s13227-020-00156-9
UR  - http://hdl.handle.net/10044/1/91773
VL  - 11
ER  -
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