Imperial College London
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Mr Ahmed R. Ahmed PhD FRCS

Faculty of Medicine, Department of Surgery & Cancer

Clinical Reader in Metabolic Surgery
 
 
 
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Contact

 

+44 (0)20 8846 1081a.ahmed07

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Behary:2023:10.1111/dom.15028,
author = {Behary, P and Alessimii, H and Miras, AD and Tharakan, G and Alexiadou, K and Aldhwayan, MM and Purkayastha, S and Moorthy, K and Ahmed, AR and Bloom, SR and Tan, TM},
doi = {10.1111/dom.15028},
journal = {Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics},
pages = {1731--1739},
title = {Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: a secondary analysis of a randomized single-blind placebo-controlled study},
url = {http://dx.doi.org/10.1111/dom.15028},
volume = {25},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AimsTo investigate whether the elevation in postprandial concentrations of the gut hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM) and peptide YY (PYY) accounts for the beneficial changes in food preferences, sweet taste function and eating behaviour after Roux-en-Y gastric bypass (RYGB).Materials and methodsThis was a secondary analysis of a randomized single-blind study in which we infused GLP-1, OXM, PYY (GOP) or 0.9% saline subcutaneously for 4 weeks in 24 subjects with obesity and prediabetes/diabetes, to replicate their peak postprandial concentrations, as measured at 1 month in a matched RYGB cohort (ClinicalTrials.gov NCT01945840). A 4-day food diary and validated eating behaviour questionnaires were completed. Sweet taste detection was measured using the method of constant stimuli. Correct sucrose identification (corrected hit rates) was recorded, and sweet taste detection thresholds (EC50s: half maximum effective concencration values) were derived from concentration curves. The intensity and consummatory reward value of sweet taste were assessed using the generalized Labelled Magnitude Scale.ResultsMean daily energy intake was reduced by 27% with GOP but no significant changes in food preferences were observed, whereas a reduction in fat and increase in protein intake were seen post-RYGB. There was no change in corrected hit rates or detection thresholds for sucrose detection following GOP infusion. Additionally, GOP did not alter the intensity or consummatory reward value of sweet taste. A significant reduction in restraint eating, comparable to the RYGB group was observed with GOP.ConclusionThe elevation in plasma GOP concentrations after RYGB is unlikely to mediate changes in food preferences and sweet taste function after surgery but may promote restraint eating.
AU  - Behary,P
AU  - Alessimii,H
AU  - Miras,AD
AU  - Tharakan,G
AU  - Alexiadou,K
AU  - Aldhwayan,MM
AU  - Purkayastha,S
AU  - Moorthy,K
AU  - Ahmed,AR
AU  - Bloom,SR
AU  - Tan,TM
DO  - 10.1111/dom.15028
EP  - 1739
PY  - 2023///
SN  - 1462-8902
SP  - 1731
TI  - Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: a secondary analysis of a randomized single-blind placebo-controlled study
T2  - Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics
UR  - http://dx.doi.org/10.1111/dom.15028
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000948478800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.15028
UR  - http://hdl.handle.net/10044/1/104349
VL  - 25
ER  -
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