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@article{Jeong:2019:10.3390/ijerph16040600,
author = {Jeong, A and Imboden, M and Ghantous, A and Novoloaca, A and Carsin, A-E and Kogevinas, M and Schindler, C and Lovison, G and Herceg, Z and Cuenin, C and Vermeulen, R and Jarvis, D and Amaral, A and Kronenberg, F and Vineis, P and Probst-Hensch, N},
doi = {10.3390/ijerph16040600},
journal = {International Journal of Environmental Research and Public Health},
title = {DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma},
url = {http://dx.doi.org/10.3390/ijerph16040600},
volume = {16},
year = {2019}
}

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TY  - JOUR
AB  - A high body mass (BMI) index has repeatedly been associated with non-atopic asthma, but the biological mechanism linking obesity to asthma is still poorly understood. We aimed to test the hypothesis that inflammation and/or innate immunity plays a role in the obesity-asthma link. DNA methylome was measured in blood samples of 61 non-atopic participants with asthma and 146 non-atopic participants without asthma (non-smokers for at least 10 years) taking part in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) study. Modification by DNA methylation of the association of BMI or BMI change over 10 years with adult-onset asthma was examined at each CpG site and differentially methylated region. Pathway enrichment tests were conducted for genes in a priori curated inflammatory pathways and the NLRP3-IL1B-IL17 axis. The latter was chosen on the basis of previous work in mice. Inflammatory pathways including glucocorticoid/PPAR signaling (p = 0.0023), MAPK signaling (p = 0.013), NF-κB signaling (p = 0.031), and PI3K/AKT signaling (p = 0.031) were enriched for the effect modification of BMI, while NLRP3-IL1B-IL17 axis was enriched for the effect modification of BMI change over 10 years (p = 0.046). DNA methylation measured in peripheral blood is consistent with inflammation as a link between BMI and adult-onset asthma and with the NLRP3-IL1B-IL17 axis as a link between BMI change over 10 years and adult-onset asthma in non-atopic participants.
AU  - Jeong,A
AU  - Imboden,M
AU  - Ghantous,A
AU  - Novoloaca,A
AU  - Carsin,A-E
AU  - Kogevinas,M
AU  - Schindler,C
AU  - Lovison,G
AU  - Herceg,Z
AU  - Cuenin,C
AU  - Vermeulen,R
AU  - Jarvis,D
AU  - Amaral,A
AU  - Kronenberg,F
AU  - Vineis,P
AU  - Probst-Hensch,N
DO  - 10.3390/ijerph16040600
PY  - 2019///
SN  - 1660-4601
TI  - DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma
T2  - International Journal of Environmental Research and Public Health
UR  - http://dx.doi.org/10.3390/ijerph16040600
UR  - http://hdl.handle.net/10044/1/67649
VL  - 16
ER  -

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