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BibTex format

@article{Barr:2015:10.1038/srep10564,
author = {Barr, AR and Bakal, C},
doi = {10.1038/srep10564},
journal = {Scientific Reports},
title = {A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly},
url = {http://dx.doi.org/10.1038/srep10564},
volume = {5},
year = {2015}
}

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TY  - JOUR
AB  - How multiple spindle assembly pathways are integrated to drive bipolar spindle assembly is poorly understood. We performed an image-based double RNAi screen to identify genes encoding Microtubule-Associated Proteins (MAPs) that interact with the highly conserved ch-TOG gene to regulate bipolar spindle assembly in human cells. We identified a ch-TOG centred network of genetic interactions which promotes centrosome-mediated microtubule polymerisation, leading to the incorporation of microtubules polymerised by all pathways into a bipolar structure. Our genetic screen also reveals that ch-TOG maintains a dynamic microtubule population, in part, through modulating HSET activity. ch-TOG ensures that spindle assembly is robust to perturbation but sufficiently dynamic such that spindles can explore a diverse shape space in search of structures that can align chromosomes.
AU  - Barr,AR
AU  - Bakal,C
DO  - 10.1038/srep10564
PY  - 2015///
SN  - 2045-2322
TI  - A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep10564
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000355648900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/70558
VL  - 5
ER  -

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