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BibTex format

@article{Pennycook:2020:10.1002/1873-3468.13867,
author = {Pennycook, BR and Barr, AR},
doi = {10.1002/1873-3468.13867},
journal = {FEBS Letters},
pages = {2046--2060},
title = {Restriction point regulation at the crossroads between quiescence and cell proliferation},
url = {http://dx.doi.org/10.1002/1873-3468.13867},
volume = {594},
year = {2020}
}

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TY  - JOUR
AB  - The coordination of cell proliferation with reversible cell cycle exit into quiescence is crucial for the development of multicellular organisms and for tissue homeostasis in the adult. The decision between quiescence and proliferation occurs at the restriction point, which is widely thought to be located in the G1 phase of the cell cycle, when cells integrate accumulated extracellular and intracellular signals to drive this binary cellular decision. On the molecular level, decision-making is exerted through the activation of cyclin-dependent kinases (CDKs). CDKs phosphorylate the retinoblastoma (Rb) transcriptional repressor to regulate the expression of cell cycle genes. Recently, the classical view of restriction point regulation has been challenged. Here, we review the latest findings on the activation of CDKs, Rb phosphorylation and the nature and position of the restriction point within the cell cycle.
AU  - Pennycook,BR
AU  - Barr,AR
DO  - 10.1002/1873-3468.13867
EP  - 2060
PY  - 2020///
SN  - 0014-5793
SP  - 2046
TI  - Restriction point regulation at the crossroads between quiescence and cell proliferation
T2  - FEBS Letters
UR  - http://dx.doi.org/10.1002/1873-3468.13867
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32564372
UR  - http://hdl.handle.net/10044/1/80934
VL  - 594
ER  -

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