Imperial College London
Alternate

Dr Antonio J Berlanga-Taylor

Faculty of Medicine, School of Public Health

Honorary Senior Research Fellow
 
 
 
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Contact

 

a.berlanga

 
 
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Location

 

47 Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Disanto:2013:10.1177/1352458513477231,
author = {Disanto, G and Hall, C and Lucas, R and Ponsonby, A-L and Berlanga-Taylor, AJ and Giovannoni, G and Ramagopalan, SV and Ausimmune, Investigator Group},
doi = {10.1177/1352458513477231},
journal = {Mult Scler},
pages = {1355--1358},
title = {Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis.},
url = {http://dx.doi.org/10.1177/1352458513477231},
volume = {19},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gene-environment interactions may shed light on the mechanisms underlying multiple sclerosis (MS). We pooled data from two case-control studies on incident demyelination and used different methods to assess interaction between HLA-DRB115 (DRB1-15) and history of infectious mononucleosis (IM). Individuals exposed to both factors were at substantially increased risk of disease (OR=7.32, 95% CI=4.92-10.90). In logistic regression models, DRB1-15 and IM status were independent predictors of disease while their interaction term was not (DRB1-15IM: OR=1.35, 95% CI=0.79-2.23). However, interaction on an additive scale was evident (Synergy index=2.09, 95% CI=1.59-2.59; excess risk due to interaction=3.30, 95%CI=0.47-6.12; attributable proportion due to interaction=45%, 95% CI=22-68%). This suggests, if the additive model is appropriate, the DRB1-15 and IM may be involved in the same causal process leading to MS and highlights the benefit of reporting gene-environment interactions on both a multiplicative and additive scale.
AU  - Disanto,G
AU  - Hall,C
AU  - Lucas,R
AU  - Ponsonby,A-L
AU  - Berlanga-Taylor,AJ
AU  - Giovannoni,G
AU  - Ramagopalan,SV
AU  - Ausimmune,Investigator Group
DO  - 10.1177/1352458513477231
EP  - 1358
PY  - 2013///
SP  - 1355
TI  - Assessing interactions between HLA-DRB115 and infectious mononucleosis on the risk of multiple sclerosis.
T2  - Mult Scler
UR  - http://dx.doi.org/10.1177/1352458513477231
UR  - https://www.ncbi.nlm.nih.gov/pubmed/23413297
VL  - 19
ER  -
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