Imperial College London
Dr Andrea Bernardi

DrAndreaBernardi

Faculty of Engineering, Department of Chemical Engineering

Research Fellow
 
 
 
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Contact

 

a.bernardi13

 
 
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Location

 

RODH 501Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bernardi:2022:10.1016/j.compchemeng.2021.107582,
author = {Bernardi, A and Sarkis, M and Triantafyllou, N and Lakelin, M and Shah, N and Papathanasiou, MM},
doi = {10.1016/j.compchemeng.2021.107582},
journal = {Computers & Chemical Engineering},
pages = {107582--107582},
title = {Assessment of intermediate storage and distribution nodes in personalised medicine},
url = {http://dx.doi.org/10.1016/j.compchemeng.2021.107582},
volume = {157},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chimeric Antigen Receptor (CAR) T cell therapies are a type of patient-specific cell immunotherapy demonstrating promising results in the treatment of aggressive blood cancer types. CAR T cells follow a 1:1 business model, translating into manufacturing lines and distribution nodes being exclusive to the production of a single therapy, hindering volumetric scale up. In this work, we address manufacturing capacity bottlenecks via a Mixed Integer Linear Programming (MILP) model. The proposed formulation focuses on the design of candidate supply chain network configurations under different demand scenarios. We investigate the effect of an intermediate storage upstream of the network to: (a) debottleneck manufacturing lines and (b) increase facility utilisation. In this setting, we assess cost-effectiveness and flexibility of the supply chain and we evaluate network performance with respect to: (a) average production cost and (b) average response treatment time. The trade-off between cost-efficiency and responsiveness is examined and discussed.
AU  - Bernardi,A
AU  - Sarkis,M
AU  - Triantafyllou,N
AU  - Lakelin,M
AU  - Shah,N
AU  - Papathanasiou,MM
DO  - 10.1016/j.compchemeng.2021.107582
EP  - 107582
PY  - 2022///
SN  - 0098-1354
SP  - 107582
TI  - Assessment of intermediate storage and distribution nodes in personalised medicine
T2  - Computers & Chemical Engineering
UR  - http://dx.doi.org/10.1016/j.compchemeng.2021.107582
UR  - https://www.sciencedirect.com/science/article/pii/S0098135421003604?via%3Dihub
UR  - http://hdl.handle.net/10044/1/92684
VL  - 157
ER  -
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