Imperial College London

MrAndreaBernardini

Faculty of EngineeringDepartment of Mechanical Engineering

Research Postgraduate
 
 
 
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Contact

 

a.bernardini16 CV

 
 
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Location

 

564City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

2 results found

Jamal A, Mongelli M, Vidotto M, Madekurozwa M, Bernardini A, Overby D, De Momi E, Rodriguez y Baena F, Sherwood J, Dini Det al., 2020, Infusion mechanisms in brain white matter and its dependence of microstructure: An experimental study of hydraulic permeability, IEEE Transactions on Biomedical Engineering, ISSN: 0018-9294

Objective: Hydraulic permeability is a topic of deep interest in biological materials because of its important role in a range of drug delivery-based therapies. The strong dependence of permeability on the geometry and topology of pore structure and the lack of detailed knowledge of these parameters in the case of brain tissue makes the study more challenging. Although theoretical models have been developed for hydraulic permeability, there is limited consensus on the validity of existing experimental evidence to complement these models. In the present study, we measure the permeability of white matter (WM) of fresh ovine brain tissue considering the localised heterogeneities in the medium using an infusion based experimental set up, iPerfusion. We measure the flow across different parts of the WM in response to applied pressures for a sample of specific dimensions and calculate the permeability from directly measured parameters. Furthermore, we directly probe the effect of anisotropy of the tissue on permeability by considering the directionality of tissue on the obtained values. Additionally, we investigate whether WM hydraulic permeability changes with post-mortem time. To our knowledge, this is the first report of experimental measurements of the localised WM permeability, showing the effect of axon directionality on permeability. This work provides a significant contribution to the successful development of intra-tumoural infusion-based technologies, such as convection-enhanced delivery (CED), which are based on the delivery of drugs directly by injection under positive pressure into the brain.

Journal article

Tan Z, Bernardini A, Konstantinou I, Forte AE, Galvan S, Van Wachem B, Dini D, Rodriguez Y Baena Fet al., 2017, Diffusion Measurement and Modelling, European Robotics Forum 2017

Conference paper

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